Controller for a Continuous Near Infrared Glucose Sensor

Author(s):  
Kiran Kanukurthy ◽  
Usha Viswanathan ◽  
David Andersen ◽  
Jon Olesberg ◽  
Mark Arnold ◽  
...  
Keyword(s):  
2014 ◽  
Vol 43 (6) ◽  
pp. 793-795 ◽  
Author(s):  
Junya Yoshimoto ◽  
Naoki Tanaka ◽  
Mitsuru Inada ◽  
Ryuichi Arakawa ◽  
Hideya Kawasaki

1997 ◽  
Vol 51 (10) ◽  
pp. 1559-1564 ◽  
Author(s):  
Michael J. McShane ◽  
Gerard L. Coté ◽  
Clifford Spiegelman

A variable selection method that reduces prediction bias in partial least-squares regression models was developed and applied to near-infrared absorbance spectra of glucose in pH buffer and cell culture medium. Comparisons between calibration and prediction capability for full spectra and reduced sets were completed. Variable selection resulted in statistically equivalent errors while reducing the number of wavelengths needed to fit the calibration data and predict concentrations from new spectra. Fewer than 25 wavelengths were selected to produce errors statistically equivalent to those yielded by the full set containing over 500 wavelengths. The algorithm correctly chose the glucose absorption peak areas as the information-carrying spectral regions.


PEDIATRICS ◽  
1992 ◽  
Vol 90 (2) ◽  
pp. 193-195
Author(s):  
L. Skov ◽  
O. Pryds

Changes in cerebral blood volume (CBV) were investigated by means of near-infrared spectroscopy in 18 preterm newborns during treatment with intravenous bolus glucose. All newborns were breathing spontaneously, and their postnatal age was 2 hours. Blood glucose concentration ranged between 0.3 and 2.2 mmol/L. Cerebral blood volume began to decrease shortly after the glucose infusion was terminated, and steady state was obtained after approximately 3 minutes. The decrease in CBV averaged 0.15 mL/100 g (range 0.02 to 0.40 mL/100 g). Thereafter, CBV remained constant. Individual reductions in CBV were inversely related to the pretreatment concentration of glucose, whereas there was no relation between changes in CBV and alterations in blood gas values or in mean arterial blood pressure. It is suggested that previously unperfused capillaries are recruited to maintain the glucose transport into neurons of hypoglycemic, preterm newborns. The rapidity whereby vessels adjust to alterations in glucose levels indicates the existence of a cerebral glucose sensor.


2015 ◽  
Vol 9 (10) ◽  
pp. 1033-1043 ◽  
Author(s):  
Ben Aernouts ◽  
Sandeep Sharma ◽  
Karolien Gellynck ◽  
Lieven Vlaminck ◽  
Maria Cornelissen ◽  
...  

2015 ◽  
Vol 68 ◽  
pp. 371-381 ◽  
Author(s):  
Evangelia Vezouviou ◽  
Christopher R. Lowe
Keyword(s):  

Author(s):  
Lorna K. Mayo ◽  
Kenneth C. Moore ◽  
Mark A. Arnold

An implantable artificial endocrine pancreas consisting of a glucose sensor and a closed-loop insulin delivery system could potentially replace the need for glucose self-monitoring and regulation among insulin dependent diabetics. Achieving such a break through largely depends on the development of an appropriate, biocompatible membrane for the sensor. Biocompatibility is crucial since changes in the glucose sensors membrane resulting from attack by orinter action with living tissues can interfere with sensor reliability and accuracy. If such interactions can be understood, however, compensations can be made for their effects. Current polymer technology offers several possible membranes that meet the unique chemical dynamics required of a glucose sensor. Two of the most promising polymer membranes are polytetrafluoroethylene (PTFE) and silicone (Si). Low-voltage scanning electron microscopy, which is an excellent technique for characterizing a variety of polymeric and non-conducting materials, 27 was applied to the examination of experimental sensor membranes.


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