Engineering Water-Dispersible FePt Nanoparticles for Biomedical Applications

The design and fabrication of Si-based multi-functional nanomaterials for biological and biomedical applications is an active area of research. The potential benefits of using Si-based nanomaterials are not only due to their size/surface-dependent optical responses but also the high biocompatibility and low-toxicity of silicon itself. Combining these characteristics with the magnetic properties of Fe3O4 nanoparticles (NPs) multiplies the options available for real-world applications. In the current study, biocompatible magnetofluorescent nano-hybrids have been prepared by covalent linking of Si quantum dots to water-dispersible Fe3O4 NPs via dicyclohexylcarbodiimide (DCC) coupling. We explore some of the properties of these magnetofluorescent nano-hybrids as well as evaluate uptake, the potential for cellular toxicity, and the induction of acute cellular oxidative stress in a mast cells-like cell line (RBL-2H3) by heat induction through short-term radio frequency modulation (10 min @ 156 kHz, 500 A). We found that the NPs were internalized readily by the cells and also penetrated the nuclear membrane. Radio frequency activated nano-hybrids also had significantly increased cell death where > 50% of the RBL-2H3 cells were found to be in an apoptotic or necrotic state, and that this was attributable to increased triggering of oxidative cell stress mechanisms.

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Highly water-dispersible PEG surface modified ultra small superparamagnetic iron oxide nanoparticles useful for target-specific biomedical applications

Nanotechnology ◽

10.1088/0957-4484/19/36/365603 ◽

2008 ◽

Vol 19 (36) ◽

pp. 365603 ◽

Cited By ~ 97

Author(s):

Ja Young Park ◽

Patel Daksha ◽

Gang Ho Lee ◽

Seungtae Woo ◽

Yongmin Chang

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Biomedical Applications ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Water Dispersible ◽

Surface Modified

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FePt Nanoparticles as Promising Magnetic Nanobeads for Biomedical Applications

Journal of the Japan Society of Powder and Powder Metallurgy ◽

10.2497/jjspm.61.s104 ◽

2014 ◽

Vol 61 (S1) ◽

pp. S104-S110

Author(s):

S. Maenosono ◽

T. T. Trinh ◽

T. T. T. Nguyen ◽

D. Mott

Keyword(s):

Biomedical Applications ◽

Fept Nanoparticles ◽

Magnetic Nanobeads

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Water-Dispersible FePt Nanoparticles Having ω-Mercapto-α-carboxylic Acid Ligands

MRS Proceedings ◽

10.1557/proc-853-i4.5 ◽

2004 ◽

Vol 853 ◽

Author(s):

Janis K. Mabry ◽

Laura Beth Tackett ◽

Hitesh Bargaria ◽

Xiangcheng Sun ◽

Earl T. Ada ◽

...

Keyword(s):

Oleic Acid ◽

Ammonium Hydroxide ◽

Photoelectron Spectra ◽

Fept Nanoparticles ◽

X Ray ◽

Water Dispersible ◽

Ordered Arrays ◽

Oleyl Amine ◽

Counter Ions ◽

Thiol Ligand

ABSTRACTFePt nanoparticles, ∼ 2nm in diameter, were prepared by the polyol reduction of platinum(II) acetylacetonate and iron(III) acetylacetonate in the presence of oleyl amine and oleic acid surfactants. The particles were dispersed in hexane and the dispersion added to a solution of 11-mercaptoundecanoic acid in cyclohexanone. As the 11-mercaptoundecanoic acid ligands replaced the oleic acid ligands, the particles precipitated. The particles could be dispersed in basic water, made basic either with sodium hydroxide or ammonium hydroxide. X-ray photoelectron spectra showed a peak near 164 eV, sulfur (2p) confirming the presence of the thiol ligand. Similarly, the oleic acid ligands were replaced with either 3-mercaptopropionic acid or 16-mercaptohexadecanoic acid to give FePt particles that could be dispersed in water. Dispersions made with FePt nanoparticles having 11-mercaptoundeacnoic acid ligands and ammonium counter ions were dried on TEM grids to give highly ordered films consisting of close-packed arrays of FePt nanoparticles. When the counter ion was sodium, the particles tended to aggregate, instead of forming ordered arrays.

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