Prevalence of atopy and staphylococcal superantigen‐specific immunoglobulin E (IgE) antibodies and total serum IgE in primary cutaneous T‐ and B‐cell lymphoma

The relationship between airway responsiveness to inhaled antigen and histamine, immunologic release of lung histamine, immunologic responsiveness of skin, and specific immunoglobulin E (IgE) antibodies were examined in 11 inbred allergic dogs immunized with extracts of ragweed and grass and 5 nonimmunized control dogs from the same colony. Airway responsiveness to antigen and histamine was characterized by the doses that increased the airflow resistance of the total respiratory system to twice the control values (ED200). Highly significant correlations were found between airway responsiveness and cutaneous responsiveness to antigen and other immunologic characteristics (e.g., IgE and histamine released from lung by inhaled antigen) in all dogs. In ragweed-sensitized dogs, there was an inverse correlation between immunologic responsiveness (reflected by the cutaneous response to antigen and histamine released from lung by inhaled antigen) and nonimmunologic responsiveness of airways (histamine ED200: r = 0.73, P less than 0.05 and r = 0.75, P less than 0.01, respectively). Antigen ED200 was also correlated with histamine release from lung after antigen inhalation (r = 0.74; P less than 0.01). We conclude that airway reactions to inhaled antigen in allergic dogs are dependent not only on immunologic factors but also on the degree of nonimmunologic airway responsiveness to histamine and that these factors are correlated inversely.

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Faecal eosinophil cationic protein and serum immunoglobulin E in relation to infant feeding practices

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563216653417 ◽

2016 ◽

Vol 54 (2) ◽

pp. 246-252 ◽

Cited By ~ 3

Author(s):

Man-Chin Hua ◽

Chien-Chang Chen ◽

Sui-Ling Liao ◽

Tsung-Chieh Yao ◽

Ming-Han Tsai ◽

...

Keyword(s):

Intestinal Inflammation ◽

Immunoglobulin E ◽

Eosinophil Cationic Protein ◽

Serum Immunoglobulin ◽

Breastfeeding Duration ◽

Total Serum ◽

Cationic Protein ◽

Solid Foods ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin

Background To date, the effects of exclusive breastfeeding duration and timing of solid food introduction on allergy prevention are unclear. The aim of this study was to determine the effect of variable feeding practices on intestinal inflammation in infants using faecal eosinophil cationic protein as a surrogate marker and to assess whether faecal eosinophil cationic protein is associated with serum immunoglobulin E. Methods Subjects ( n = 206) were enrolled from the Prediction of Allergies in Taiwanese CHildren (PATCH) birth cohort study. Stool samples were collected at 6 and 12 months for determining eosinophil cationic protein, and blood was collected for determining total and allergen-specific immunoglobulin E at 12 months. We compared these biomarkers between infants with variable exclusive breastfeeding duration and infants introduced to solid foods at various periods. The association between faecal eosinophil cationic protein, total serum immunoglobulin E and specific immunoglobulin E was also analysed. Results Faecal eosinophil cationic protein was significantly higher in exclusively breastfed infants compared with formula-fed infants and infants who were not exclusively breastfed at 6 months of age ( P < 0.05). At 12 months, infants who were introduced to solid foods at 5–6 months had the lowest faecal eosinophil cationic protein compared with those who were introduced at earlier and later periods. There was no significant association between faecal eosinophil cationic protein and serum immunoglobulin E. Conclusion We found that breastfeeding exclusively for >6 months did not reduce serum immunoglobulin E, but rather increased intestinal inflammation. Faecal eosinophil cationic protein was not associated with total serum immunoglobulin E and specific immunoglobulin E and might not be a useful indictor of immunoglobulin E sensitization in infancy.

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Longitudinal analysis of total serum IgE levels with allergen sensitization and atopic diseases in early childhood

Scientific Reports ◽

10.1038/s41598-020-78272-8 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Chun-Ying Wong ◽

Kuo-Wei Yeh ◽

Jing-Long Huang ◽

Kuan-Wen Su ◽

Ming-Han Tsai ◽

...

Keyword(s):

Early Childhood ◽

Longitudinal Analysis ◽

Immunoglobulin E ◽

Birth Cohort Study ◽

Total Serum ◽

Atopic Diseases ◽

Serum Samples ◽

Serum Ige ◽

Specific Immunoglobulin E ◽

Inhalant Allergens

AbstractThere are few studies addressing the longitudinal analysis of serum IgE levels and its impact to the development of atopic diseases in early childhood. We investigated 170 children who regularly followed up at our clinic for 4 years in a birth cohort study with at least 3 time-points of serum samples. The pattern of total serum IgE levels from 6 months to 4 years of age was clustered using K-means method in R software. Specific immunoglobulin E antibodies against food (egg white and milk) and inhalant allergens (D. pteronyssinus and D. farinae) were measured at 0.5, 1, 1.5, 2, 3 and 4 years of age. By using K-means clustering, the dynamic changes in serum IgE levels was significantly stratified into 3 clusters (cluster A, < 100 kU/L, n = 106; cluster B, 100–200 kU/L, n = 35; cluster C, ≥ 200 kU/L, n = 29). A persistent total IgE levels higher than 100 kU/L appeared to be associated with higher prevalence of sensitization to food but not mite. However, a persistent IgE levels higher than 200 kU/L was not only remarkably related to increased prevalence of mite sensitization, but also risk of eczema at age 1 and allergic rhinitis and asthma at age 2, 3 and 4. In conclusion, a persistent total serum IgE level ≥ 200 kU/L since infancy is strongly associated with the presence of food and mite sensitization, as well as the development of eczema in infants, and rhinitis and asthma later in early childhood.

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Serum Immunoglobulin E Levels in Patients with Allergic Conjunctivitis and Contact Lens Wearers

Asian Journal of Ophthalmology ◽

10.35119/asjoo.v12i3.304 ◽

1970 ◽

Vol 12 (3) ◽

pp. 152-155

Author(s):

Ozlem Gurses Sahin ◽

Nusret Taheri

Keyword(s):

Contact Lens ◽

Allergic Conjunctivitis ◽

Immunoglobulin E ◽

Total Duration ◽

Serum Immunoglobulin ◽

Total Serum ◽

Enzyme Linked Immunosorbent Assay ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin

Aim: To determine the differences between total and serum-specific immunoglobulin E levels in patients with type 1 allergic conjunctivitis and asymptomatic contact lens wearers. The correlation of total serum immunoglobulin E level of asymptomatic contact lens wearers with contact lens wearing time, and total duration of contact lens use was also evaluated.Methods: This was a case-control study involving 25 asymptomatic contact lens wearers, 25 patients with type 1 allergic conjunctivitis, and 25 age- and sex-matched healthy controls. Total serum immunoglobulin E levels were detected by enzyme-linked immunosorbent assay. Serum-specific IgE analysis against the listed indoor, food, and outdoor allergens were studied by immunofluorescence assay for participants whose total serum immunoglobulin E levels were >100 IU/mL. Pearson’s and Spearman’s correlations were used for bivariate analysis. Statistical significance was accepted at the 0.05 level.Results: The mean level of total serum immunoglobulin E was greater for patients with type 1 allergic conjunctivitis than for contact lens wearers and controls. Serum-specific immunoglobulin E detected in patients with type 1 allergic conjunctivitis was against indoor, food, and outdoor allergens, while serum-specific immunoglobulin E detected in contact lens wearers was only against outdoor allergens. A statistically significant correlation was found for total serum immunoglobulin E levels of contact lens wearers with contact lens wearing time.Conclusions: These results suggest that differences in serum total and specific immunoglobulin E levels exist between patients with type 1 allergic conjunctivitis and CL wearers and controls. Further research in a larger group of patients is needed to validate these findings.

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Increased allergic reactivity of atopic type in mood disorders and schizophrenia

European Psychiatry ◽

10.1016/s0924-9338(97)83299-3 ◽

1997 ◽

Vol 12 (5) ◽

pp. 249-254

Author(s):

M Dabkowska ◽

JK Rybakowski

Keyword(s):

Mood Disorders ◽

Immunoglobulin E ◽

Ige Antibodies ◽

Intradermal Tests ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Schizophrenic Patients ◽

Positive Results ◽

Pituitary Adrenal Axis

SummaryThe allergic reactivity of atopic type was investigated in 54 patients with mood disorders in the course of depressive episode and in 39 patients with schizophrenia. The assessment was done by three methods: intradermal tests, determination of IgE concentration and determination of specific immunoglobulin E (IgE) antibodies. The hypersensitivity to three or more allergens on intradermal tests was found in 40% of depressive and in 27% of schizophrenic patients. The concentration of IgE > 100 IU/mL was found in 45% of patients with depression and in 46% of patients with schizophrenia, more frequently in subjects with hyperactivity of hypothalamic-pituitary-adrenal axis, and in depression, in patients with higher intensity of symptoms. The positive results of the Phadiatop test which detects specific antibodies for inhalatory antigens, were found in 46% of depressive and in 40% of schizophrenic patients The indices of atopy for all three tests were higher in males than in females in both mood disorders and in schizophrenia. However, these indices were similar for unipolar and bipolar depressed patients as well as for patients with paranoid or residual schizophrenia.

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