Biologics modulate antinuclear antibodies, immunoglobulin E, and eosinophil counts in psoriasis patients

2021 ◽  
Author(s):  
Riichiro Sugiura ◽  
Hitoshi Terui ◽  
Ryoko Shimada‐Omori ◽  
Emi Yamazaki ◽  
Kenichiro Tsuchiyama ◽  
...  
Keyword(s):  
Antinuclear Antibodies ◽  
Immunoglobulin E ◽  
Eosinophil Counts

Immunoglobulin E and eosinophil counts are increased after sepsis in trauma patients

1998 ◽  
Vol 26 (3) ◽  
pp. 465-469 ◽  
Author(s):  
Joseph T. DiPiro ◽  
Thomas R. Howdieshell ◽  
Robert G. Hamilton ◽  
Arlie R. Mansberger
Keyword(s):  
Immunoglobulin E ◽  
Trauma Patients ◽  
Eosinophil Counts

Increased rate of positive penicillin skin tests among patients with glioma: insights into the association between allergies and glioma risk

2014 ◽  
Vol 121 (5) ◽  
pp. 1176-1184 ◽  
Author(s):  
Sheng Han ◽  
Yanming Huang ◽  
Zixun Wang ◽  
Zhonghua Li ◽  
Xiaofei Qin ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Conditional Logistic Regression ◽  
Large Population ◽  
Skin Tests ◽  
Food Allergies ◽  
Blood Eosinophil ◽  
Retrospective Case ◽  
Logistic Regression Models ◽  
Glioma Risk ◽  
Eosinophil Counts

Object Allergy and immunoglobulin E levels are inversely associated with glioma risk. Previous studies have focused on respiratory and food allergies, and little information is available regarding drug allergies. This study evaluated the rate of positive penicillin skin tests (PenSTs) and blood eosinophil counts in a large population of patients with glioma compared with nontumor controls to provide evidence for the relationship between drug allergies and glioma risk. Methods A retrospective case-control study was conducted in patients diagnosed with glioma (n = 913) between January 2004 and June 2013. The study patients were matched with nontumor controls (n = 1091) for age, sex, and date of admission to the hospital. Preoperative results of the PenST and eosinophil counts were obtained, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using conditional logistic regression models, while a Kaplan-Meier analysis was used to assess overall survival. Results The percentage of positive PenSTs was higher among patients with glioma than in control subjects. The age-, sex-, and admission date–adjusted OR for positive versus negative PenSTs was 2.392 (95% CI 1.891–3.026). Eosinophil counts were also higher in glioma cases than in controls: the OR for eosinophil > 0.06 × 109/L versus ≤ 0.06 × 109/L was 1.923 (95% CI 1.608–2.301). There was no association between positive PenST/eosinophil counts and glioma grade or patient survival (n = 105). Conclusions In contrast to previously reported relationships between allergy and glioma, in the present study a significantly higher rate of positive PenSTs and higher eosinophil counts were found in patients with glioma than in nontumor controls. These results suggest a complex relationship between allergies and glioma development.

scholarly journals Association Between Asthma Control Test, Peripheral Eosinophil Counts, and Serum Total Immunoglobulin E Levels in Severe Asthmatics

2016 ◽  
Vol 137 (2) ◽  
pp. AB206
Author(s):  
Santiago Alvarez Arango ◽  
Jennifer Toh ◽  
Denisa Ferastraoaru ◽  
Gabriele de Vos ◽  
David L. Rosenstreich ◽  
...  
Keyword(s):  
Asthma Control ◽  
Immunoglobulin E ◽  
Control Test ◽  
Asthma Control Test ◽  
Peripheral Eosinophil ◽  
Eosinophil Counts ◽  
Total Immunoglobulin

scholarly journals Endotype of Eosinophilic Nasal Polyposis According to the Presence of Atopy

2020 ◽  
Vol 63 (12) ◽  
pp. 579-585
Author(s):  
Do Hyun Kim ◽  
Boo-Young Kim ◽  
Il Hwan Lee ◽  
Sung Won Kim ◽  
Soo Whan Kim
Keyword(s):  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Transforming Growth Factor ◽  
Immunoglobulin E ◽  
Eosinophil Cationic Protein ◽  
Transforming Growth Factor Β ◽  
Orphan Receptor ◽  
Cationic Protein ◽  
Group A ◽  
Eosinophil Counts

Background and Objectives We evaluated differences in the pathophysiology of atopic and non-atopic eosinophilic nasal polyps and investigated their distinct inflammatory profiles.Subjects and Method A total of 36 patients were recruited: 10 controls (Group C), 14 with chronic rhinosinusitis with eosinophilic nasal polyps with atopy (Group A), and 12 without atopy (Group NA).Results Serum eosinophil counts, total immunoglobulin E, eosinophil cationic protein levels, and tissue eosinophil counts were elevated in Groups A and NA vs. Group C. Real-time polymerase chain reaction results showed increased GATA-3, interleukin (IL)-4, IL-33 levels, but decreased levels of retinoic acid-related orphan receptor gamma t, IL-17 in Groups A and NA. Related to the regulatory T (T-reg) cell response, forkhead box P3 (Foxp3<sup>+</sup>) (A: <i>p</i><0.001, NA: <i>p</i><0.001) and IL-10 (A: <i>p</i><0.001, NA: <i>p</i><0.001) levels were elevated and transforming growth factor-β levels (A: <i>p</i><0.001, NA: <i>p</i><0.001) were decreased in Group A and Group NA in comparison to those in Group C. The Foxp3<sup>+</sup> (<i>p</i>=0.001) and IL-10 (<i>p</i><0.001) were significantly higher in Group A than in Group NA.Conclusion T-reg cells and IL-10 may be major factors differentiating the pathophysiology of atopic and non-atopic eosinophilic nasal polyps, and the T helper (Th) 2/Th17/T-reg imbalance might be important in the development of eosinophilic nasal polyposis.

scholarly journals The Effect of Korean Red Ginseng on Symptoms and Inflammation in Patients With Allergic Rhinitis

2020 ◽  
pp. 014556132090717 ◽  
Author(s):  
Joo Hyun Jung ◽  
Tae Kyu Kang ◽  
Jae Hwan Oh ◽  
Jin Uk Jeong ◽  
Kwang Pil Ko ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Interleukin 4 ◽  
Total Serum ◽  
Health Improvement ◽  
Clinical Effects ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Before And After ◽  
Eosinophil Counts

Korean red ginseng (KRG) has been traditionally used in Korea for health improvement. However, the clinical effect of KRG intake on the symptoms in patients with allergic rhinitis remains unknown. Our study was performed to identify the clinical effects of KRG on patients with allergic rhinitis and to examine the effect of KRG on allergic inflammatory reaction. We evaluated 60 patients with allergic rhinitis. All the patients were treated for 4 weeks. The patients were divided into 3 groups, according to the medication. Twenty patients were treated with KRG, 20 patients with the placebo, and 20 patients with the antihistamine. The patients recorded their symptoms in a daily symptom diary card. The patients checked the peak nasal inspiratory flow rate 2 times a day. Total serum immunoglobulin E (IgE) and serum-specific IgE were measured by ImmunoCap method before and after 4-week medication. The Th2 cytokines interleukin-4 (IL-4), IL-5, and IL-10 were checked in the serum before and after the 4-week treatment. The eosinophil counts in the nasal smears were checked. Korean red ginseng group has shown the significant improvement in rhinorrhea, nasal itching, and eye itching. Both the antihistamine and KRG groups showed a significant decrease in total IgE level at the end of treatment. The serum IL-4 level and eosinophil counts in the nasal smears were significantly decreased both in the antihistamine and in the KRG groups. In conclusion, KRG might be a useful treatment modality for patients with allergic rhinitis.

scholarly journals The Effect of Curcuma longa on Inflammatory Mediators and Immunological, Oxidant, and Antioxidant Biomarkers in Asthmatic Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Mohammad Hossein Boskabady ◽  
Fatemeh Amin ◽  
Farzaneh Shakeri
Keyword(s):  
Bronchoalveolar Lavage Fluid ◽  
Immunoglobulin E ◽  
Curcuma Longa ◽  
Lavage Fluid ◽  
Interleukin 4 ◽  
Control Group ◽  
Ifn Γ ◽  
Wbc Count ◽  
Asthma Group ◽  
Eosinophil Counts

The effects of Curcuma longa (C. longa) on total and differential WBC, inflammatory and immunologic mediators, and oxidant and antioxidant biomarkers in bronchoalveolar lavage fluid (BALF) of rats model of asthma were assessed. Animals were divided to 5 groups including control (C), asthma (sensitized to ovalbumin), and asthmatic groups treated with 0.75, 1.50, and 3.00 mg/ml C. longa (CL) and 1.25 μg/ml dexamethasone (D) (8 rats in each group). Total and differential WBC count, concentrations of phospholipase A2 (PLA2), total protein (TP), interferon-gamma (IFN-γ), interleukin-4 (IL-4), immunoglobulin E (IgE), NO2, NO3, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and thiol in BALF were assessed. Total and most differential WBC counts and BALF levels of PLA2, TP, IgE, IL-4, and oxidants in asthma group were higher but antioxidants and IFN-γ levels as well as IFN-γ/IL-4 ratio were lower than control group ( p  < 0.001 for all cases). Total WBC and levels of PLA2, IgE, NO2, and NO3 were significantly reduced following treatment with C. longa, compared to asthma group ( p  < 0.001 for all cases). In groups treated with dexamethasone and two higher concentrations of C. longa, neutrophil and eosinophil counts as well as TP, IL-4, and MDA levels were significantly decreased but IFN-γ, IFN-γ/IL-4 ratio, and antioxidants were increased (except IFN-γ/IL-4 ratio), compared to asthma group ( p  < 0.05 to p  < 0.001). Compared to dexamethasone, C. longa exerted more pronounced effects on lung inflammation, oxidative stress, and immune system in asthmatic rats.

scholarly journals Effect of Antiasthma Medication on Blood Eosinophil Count and Serum Immunoglobulin E Levels: A Randomized Controlled Study

2020 ◽  
pp. 33-39
Author(s):  
Wasim A. Wani ◽  
Sheeraz A. Dar ◽  
Khalid M. Kawosa ◽  
Mudasir Nazir ◽  
Ikhlas Ahmad ◽  
...  
Keyword(s):  
Eosinophil Count ◽  
Immunoglobulin E ◽  
Airflow Obstruction ◽  
Controlled Study ◽  
Blood Eosinophil ◽  
Blood Eosinophil Count ◽  
Serum Ige ◽  
Randomized Controlled ◽  
Chronic Inflammatory Condition ◽  
Eosinophil Counts

Background: Asthma is a chronic inflammatory condition of lung airways resulting in episodic airflow obstruction. Aims: The main objective of this study is to find the effect of antiasthma medication on serum IgE levels and blood eosinophil count. Study Design: This randomized controlled trial study was performed in children aged 6-15 years of age, with clinically stable and moderate persistent asthma. Results: The findings of this study indicate both group (Budesonide/formoterol group and budesonide group) patients experienced a significant decrease in serum IgE levels and blood eosinophil counts over the study period. However, the difference in two groups was not statistically significant. Conclusions: Inhaled steroids are effective in controlling systemic inflammation in asthma as evidenced by a decrease in IgE levels and eosinophil counts. However addition of LABA doesn’t have any additive effect.

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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