Cardiac function in gestational diabetes mellitus: A longitudinal study from fetal life to infancy

AbstractObjective:The purpose of this study was to assess fetal cardiac function in normal fetuses (control group) compared to those who are exposed to gestational diabetes mellitus using different echocardiographic measurements, and to explore the application of left atrial shortening fraction in determination of fetal diastolic function with gestational diabetes mellitus.Methods:A total of 50 women with gestational diabetes and 50 women with a healthy pregnancy were included in the study. Fetal echocardiography was performed and structural as well as functional fetal cardiac parameters were measured. Data were compared between with or without fetal myocardial hypertrophy and the control group.Results:In the study group, out of 50 fetuses of gestational diabetic mothers, 18 had myocardial hypertrophy and 32 had normal septal thickness. Gestational age at time of examination did not differ significantly between the control and gestational diabetes group (p = 0.55). Mitral E/A ratio was lower in gestational diabetes group as compared to the control (p < 0.001). Isovolumetric relaxation and contraction times and myocardial performance index were greater in fetuses of gestational diabetic mothers (p < 0.001). In fetuses of gestational diabetic mothers with myocardial hypertrophy, left atrial shortening fraction was lower as compared to those without myocardial hypertrophy and those of the control group (p < 0.001).Conclusions:The results of this study suggest that fetuses of gestational diabetic mothers have altered cardiac function even in the absence of septal hypertrophy, and that left atrial shortening fraction can be used as a reliable alternate parameter in the assessment of fetal diastolic function.

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Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study in a multiracial cohort

Diabetes Obesity and Metabolism ◽

10.1111/dom.13748 ◽

2019 ◽

Vol 21 (8) ◽

pp. 1895-1905 ◽

Cited By ~ 9

Author(s):

Jin Xia ◽

Yiqing Song ◽

Shristi Rawal ◽

Jing Wu ◽

Stefanie N. Hinkle ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Longitudinal Study ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Status

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A Longitudinal Study of Lipids and Blood Pressure in Relation to Method of Contraception in Latino Women With Prior Gestational Diabetes Mellitus

Diabetes Care ◽

10.2337/dc07-0180 ◽

2007 ◽

Vol 30 (8) ◽

pp. 1952-1958 ◽

Cited By ~ 14

Author(s):

A. H. Xiang ◽

M. Kawakubo ◽

T. A. Buchanan ◽

S. L. Kjos

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Longitudinal Study ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Latino Women

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Evaluation of fetal cardiac function in maternal gestational diabetes mellitus by speckle tracking echocardiography

10.21203/rs.3.rs-761354/v1 ◽

2021 ◽

Author(s):

Peina Huang ◽

Youbin Deng ◽

Ling Feng ◽

Yiping Gao ◽

Xueqing Cheng ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Right Ventricle ◽

Cardiac Function ◽

Gestational Diabetes Mellitus ◽

Right Ventricular ◽

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Fetal Cardiac Function ◽

The Right

Abstract The aim of this study was to assess the cardiac function in fetuses of mothers with gestational diabetes mellitus (GDM) by using fetalHQ, a quantitative analysis software for the assessment of fetal cardiac function based on speckle tracking echocardiography. In this prospective cross-sectional study, 49 fetuses exposed to GDM and 50 normal fetuses were enrolled and fetal echocardiography were performed and analyzed. In the GDM group, left ventricular (24 ± 4 vs. 28 ± 4, p < 0.001) and right ventricular global longitudinal strain (23 ± 4 vs. 26 ± 4, p = 0.002) and right ventricular free wall strain (26 ± 6 vs. 29 ± 5, p = 0.006) were significantly lower compared with the control group, whereas there was no significant difference in global spherical index (1.2 ± 0.1 vs. 1.2 ± 0.1, p = 0.425). Additionally, 24-segment transverse fraction shortening of the right ventricle was more impaired than the left and the segments with reduced fraction shortening were mainly located in the mid and apical sections of the right ventricle, and mid section of the left ventricle. In conclusion, fetuses exposed to GDM may have cardiac dysfunction before the onset of cardiac morphologic abnormalities, and the right ventricle is more vulnerable than the left during fetal development.

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