Comparative evaluation of the impact of the COVID‐19 lockdown on perinatal experience: a prospective multicentre study

2021 ◽  
Author(s):  
C. Bertholdt ◽  
J. Epstein ◽  
C. Alleyrat ◽  
G. Ambroise ◽  
L. Claudel ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Comparative Evaluation ◽  
Prospective Multicentre Study ◽  
The Impact

scholarly journals The impact of having a baby with cleft lip and palate on parents and on parent-baby relationship: the first French prospective multicentre study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Bruno Grollemund ◽  
◽  
Caroline Dissaux ◽  
Pascale Gavelle ◽  
Carla Pérez Martínez ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Prospective Multicentre Study ◽  
The Impact

scholarly journals The Impact of Healthcare-Associated Infections in Patients Undergoing Oncological Microvascular Head and Neck Reconstruction: A Prospective Multicentre Study

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2109
Author(s):  
Ana Ramos-Zayas ◽  
Francisco López-Medrano ◽  
Irene Urquiza-Fornovi ◽  
Ignacio Zubillaga ◽  
Ramón Gutiérrez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multicentre Study ◽  
Head And Neck ◽  
Significant Risk ◽  
Head And Neck Reconstruction ◽  
Healthcare Associated Infections ◽  
Prospective Multicentre Study ◽  
Complication Risk ◽  
Healthcare Associated ◽  
The Impact

(1) Background: Healthcare-associated infections (HAIs) after head and neck free-flap reconstruction are a common postoperative complication. Risk factors for HAIs in this context and their consequences have not been adequately described. (2) Methods: Ongoing prospective multicentre study between 02/2019 and 12/2020. Demographic characteristics and outcomes were analysed, focusing on infections. (3) Results: Forty out of 65 patients (61.54%) suffered HAIs (surgical site infection: 52.18%, nosocomial pneumonia: 23.20%, bloodstream infection: 13% and urinary tract infection: 5.80%). Methicillin-resistant Staphylococcus aureus (MRSA) and resistant Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterobacter cloacae were the most frequently implicated. The significant risk factors for infection were: previous radiotherapy (Odds ratio (OR): 5.42; 95% confidence interval (CI), 1.39–21.10), anaemia (OR: 8.00; 95% CI, 0.96–66.95), salvage surgery (eight out of eight patients), tracheostomy (OR: 2.86; 95% CI, 1.01–8.14), surgery duration (OR: 1.01; 95% CI, 1.00–1.02), microvascular reoperation <72 h (eight/eight) and flap loss (eight/eight). The major surgical complications were: a need to reoperate (OR: 6.89; 95% CI, 1.42–33.51), prolonged hospital admission (OR: 1.16; 95% CI, 1.06–1.27) and delay in the initiation of postoperative radiotherapy (OR: 9.07; 95% CI, 1.72–47.67). The sixth month mortality rate in patients with HAIs was 7.69% vs. 0% in patients without HAIs (p = 0.50). (4) Conclusions: HAIs were common after this type of surgery, many of them caused by resistant microorganisms. Some modifiable risk factors were identified. Infections played a role in cancer prognosis by delaying adjuvant therapy.

scholarly journals Geriatric fracture centre vs usual care after proximal femur fracture in older patients: what are the benefits? Results of a large international prospective multicentre study

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e039960
Author(s):  
Michael Blauth ◽  
Alexander Joeris ◽  
Elke Rometsch ◽  
Kathrin Espinoza-Rebmann ◽  
Pannida Wattanapanom ◽  
...  
Keyword(s):  
Adverse Events ◽  
Multicentre Study ◽  
Usual Care ◽  
Proximal Femur ◽  
Interdisciplinary Treatment ◽  
Proximal Femur Fracture ◽  
Geriatric Fracture ◽  
Femur Fractures ◽  
Prospective Multicentre Study ◽  
Registration Number

ObjectiveThe aim of this study was to determine the effect of treatment in geriatric fracture centres (GFC) on the incidence of major adverse events (MAEs) in patients with hip fractures compared with usual care centres (UCC). Secondary objectives included hospital-workflow and mobility-related outcomes.DesignCohort study recruiting patients between June 2015 and January 2017. Follow-up was 1 year.SettingInternational (six countries, three continents) multicentre study.Participants281 patients aged ≥70 with operatively treated proximal femur fractures.InterventionsTreatment in UCCs (n=139) or GFCs (n=142), that is, interdisciplinary treatment including regular geriatric consultation and daily physiotherapy.Outcome measuresPrimary outcome was occurrence of prespecified MAEs, including delirium. Secondary outcomes included any other adverse events, time to surgery, time in acute ward, 1-year mortality, mobility, and quality of life.ResultsPatients treated in GFCs (n=142) had a mean age of 81.9 (SD, 6.6) years versus 83.9 (SD 6.9) years in patients (n=139) treated in UCCs (p=0.013) and a higher mean Charlson Comorbidity Index of 2.0 (SD, 2.1) versus 1.2 (SD, 1.5) in UCCs (p=0.001). More patients in GFCs (28.2%) experienced an MAE during the first year after surgery compared with UCCs (7.9%) with an OR of 4.56 (95% CI 2.23 to 9.34, p<0.001). Analysing individual MAEs, this was significant for pneumonia (GFC: 9.2%; UCC: 2.9%; OR, 3.40 (95% CI 1.08 to 10.70), p=0.027) and delirium (GFC: 11.3%; UCC: 2.2%, OR, 5.76 (95% CI 1.64 to 20.23), p=0.002).ConclusionsContrary to our study hypothesis, the rate of MAEs was higher in GFCs than in UCCs. Delirium was revealed as a main contributor. Most likely, this was based on improved detection rather than a truly elevated incidence, which we interpret as positive effect of geriatric comanagement.Trial registration numberClinicalTrials.gov: NCT02297581.

Sign in / Sign up

Export Citation Format

Share Document