Analysis of dietary exposure and risk assessment of pesticide residues in roots and rhizomes of Chinese herbs

Author(s):  
Hanyi Xie ◽  
Huijuan Li ◽  
Yanfang Zhao ◽  
Lanqi Liu ◽  
Xiangfeng Chen
Author(s):  
Christine Bjørge ◽  
Marit Låg ◽  
Ragna Bogen Hetland ◽  
Agnethe Christiansen ◽  
Lise Skrettberg ◽  
...  

The present report is based on data from the 2010 EFSA Report on pesticide residues in food, the Norwegian monitoring programmes 2007-2012 and data from peer reviewed literature and governmental agencies. It is a challenge to perform quantitative estimates and comparative studies of residue levels due to large variation in the measured levels, and the large number of different pesticides present in the samples. Thus, the focus is on the frequency of observed contaminations in relation to regulatory limits and to present examples to illustrate the variation in residue values and number of detected substances.  Pesticide residues in conventional and organic products: Of the 12,168 samples (plant- and animal products) in the 2010 EU-coordinated programme, 1.6% exceeded the respective maximum residue level (MRL) values, and 47.7% had measurable residues above the limit of quantification (LOQ), but below or at the MRL. Of the 1168 samples analysed in Norway in 2012 (from both imported and domestic products), 1.9% exceeded MRL and 53% contained measurable pesticide residues. Direct comparison of these values is however not possible, since they contain different types of food samples, and are analysed for a different number of pesticides. When organic and conventional samples from fruit, vegetables and other plant products in the 2010 EU-coordinated programme were compared, 4.2% of the conventional and 1.0% of the organic samples exceeded the MRL values, while 43.2% of the conventional and 10.8% of the organic samples had measurable residues below or at the MRL value. Most of the pesticide residues detected in organic samples are not permitted for use in organic farming.  Of the 624 organic samples analysed in Norway 2007 - 2012, 0.2% (one sample) had residues exceeding MRL, while measurable residues were detected in 1.8% of the samples (11 samples). Conventional products were often found to contain different pesticides while most organic samples were found to contain few or only one type of pesticide.   Lack of data on pesticide residue levels of organic samples in the EU-coordinated programme, and few Norwegian samples do not allow for a quantitative comparison of pesticide residue levels in organic and conventional samples. Comparative estimation of pesticide residues faces a number of challenges and uncertainties. However, it seems unquestionable based on available data that organic plant products contain fewer and substantially lower amounts of pesticide residues than conventional products. Health risk associated with pesticide residues: The general level of pesticide residues in both conventional and organic food is low, and well below what is likely to result in adverse health effects. This conclusion is based on the comparison of estimated dietary exposure with toxicological reference values i.e. acceptable daily intake (ADI) for chronic effects, and acute reference dose (ARfD) for acute effects. The finding of pesticide residues that exceeds established regulatory limits in a minority of tested samples is not considered to represent a health risk. When dietary exposure that was estimated in six different food commodities in the 2010 EUcoordinated programme was compared with their relevant reference values, EFSA concluded that for 79 of 18243 conventionally grown fruit and vegetable samples, a short-term acute consumer health risk could not be excluded. The conclusion was based on the exceeding of ARfD. None of these 79 samples were organic. It is important to also consider that the exceeding of the acute reference value only occurred in 0.4% of the samples and that the scenario used for acute intake assessment is conservative, suggesting that the toxicological implications are limited. This is also reflected in the chronic exposure assessment, where none of the samples were found to exceed the toxicological reference value ADI.   Dietary exposure assessments on the basis of Norwegian samples of apples, tomatoes, carrots, strawberries and lettuce did not show an exceeding of any toxicological reference value.  Combined exposure and cumulative risk assessment of pesticide residues: No generally accepted methodology is at present established for cumulative risk assessment of combined exposure to pesticide residues. Available data suggest however that combined exposure is not likely to result in increased human health risk.


Author(s):  
Qianke Zhang ◽  
Qiqing Ge ◽  
Zihan Zhang ◽  
Jiajin Song ◽  
Shiyu Chen ◽  
...  

Abstract Background Pesticide residues in traditional Chinese medicines pose a potential risk to human health. However, little is known about the characteristics of pesticide residues in the fritillariae thunbergii bulbs (FTB). Objective This study aims to establish a method for the determination of pesticide multi-residues in FTB and then measured their residual levels in the FTB collected from nine cultivation regions. Methods A modified QuEChERS method coupled with GC/UPLC was used to determine the residues of 24 pesticides in the FTB and soil samples. Results The recoveries of these pesticides at three concentrations were 72.17–112.48% in the FTB and 70.92–113.74% in the soil with RSD < 11.83%, and the LOD and LOQ ranged from 0.005–10 μg/kg and 0.011–22 μg/kg, respectively. A total of 13 pesticide residues were detected in the FTB samples with the residual levels of 0.0011–509.63 μg/kg, which were all below the referred MRLs in other Chinese herbs or food. Meanwhile, dietary intake risk assessment showed that the risk of pesticide residues in the FTB was acceptable to consumers. Conclusions This study developed a method for the determination of pesticide multi-residues in the FTB and cultivated soil samples, and furthermore the dietary intake risk of pesticide residues in the FTB is safe. Highlights A modified QuEChERS method was established for the determination of 24 pesticides in the FTB with high sensitivity, accuracy, and precision.


Author(s):  
Lixue Kuang ◽  
Guofeng Xu ◽  
Yao Tong ◽  
Haifei Li ◽  
Jianyi Zhang ◽  
...  

The presence of pesticide residues in fruit has been of extensive concern worldwide. In this paper, pesticide residues in litchi samples in China and their dietary exposure risks were evaluated. Fifty-seven pesticides in 150 litchi samples were measured by GC and UPLC/MS-MS. Seventeen different pesticides were detected and 70.7% of samples contained one or more pesticide residues. The most frequently detected pesticide was diflubenzuron with a detection rate of 36%. Only carbofuran  in one sample exceeded its MRL and the exceedance was 125%. In dietary exposure assessments, all the values below LOD were calculated as 0, 1/2 LOD and LOD separately and the results demonstrated that the chronic dietary risks were extremely low. Acute exposure to carbofurn was 11.08% of the acute reference dose and acute exposure to all other pesticides was below 2% of the acute reference dose. The findings indicated that the occurrence of pesticide residues in litchis should not be considered a public health problem.


2021 ◽  
pp. 112116
Author(s):  
Bozidar Udovicki ◽  
Nikola Tomic ◽  
Bojana Spirovic Trifunovic ◽  
Sasa Despotovic ◽  
Jelena Jovanovic ◽  
...  

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