scholarly journals A stratified analysis of a deep learning algorithm in the diagnosis of diabetic retinopathy in a real‐world study

2021 ◽  
Author(s):  
Na Li ◽  
Mingming Ma ◽  
Mengyu Lai ◽  
Liping Gu ◽  
Mei Kang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Real World ◽  
Learning Algorithm ◽  
Deep Learning Algorithm ◽  
Stratified Analysis

scholarly journals Essentials of a Robust Deep Learning System for Diabetic Retinopathy Screening: A Systematic Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Aan Chu ◽  
David Squirrell ◽  
Andelka M. Phillips ◽  
Ehsan Vaghefi
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Validation Dataset ◽  
Cochrane Library ◽  
Clinical Implementation ◽  
Diabetic Retinopathy Screening ◽  
Deep Learning Algorithm ◽  
Retinopathy Screening

This systematic review was performed to identify the specifics of an optimal diabetic retinopathy deep learning algorithm, by identifying the best exemplar research studies of the field, whilst highlighting potential barriers to clinical implementation of such an algorithm. Searching five electronic databases (Embase, MEDLINE, Scopus, PubMed, and the Cochrane Library) returned 747 unique records on 20 December 2019. Predetermined inclusion and exclusion criteria were applied to the search results, resulting in 15 highest-quality publications. A manual search through the reference lists of relevant review articles found from the database search was conducted, yielding no additional records. A validation dataset of the trained deep learning algorithms was used for creating a set of optimal properties for an ideal diabetic retinopathy classification algorithm. Potential limitations to the clinical implementation of such systems were identified as lack of generalizability, limited screening scope, and data sovereignty issues. It is concluded that deep learning algorithms in the context of diabetic retinopathy screening have reported impressive results. Despite this, the potential sources of limitations in such systems must be evaluated carefully. An ideal deep learning algorithm should be clinic-, clinician-, and camera-agnostic; complying with the local regulation for data sovereignty, storage, privacy, and reporting; whilst requiring minimum human input.

scholarly journals Evaluasi Performasi Ruang Warna pada Klasifikasi Diabetic Retinophaty Menggunakan Convolution Neural Network

2021 ◽  
Vol 8 (3) ◽  
pp. 619
Author(s):  
Candra Dewi ◽  
Andri Santoso ◽  
Indriati Indriati ◽  
Nadia Artha Dewi ◽  
Yoke Kusuma Arbawa
Keyword(s):  
Neural Network ◽  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Learning Algorithm ◽  
Color Space ◽  
Training Data ◽  
Color Spaces ◽  
Deep Learning Algorithm ◽  
Optimal Accuracy

<p>Semakin meningkatnya jumlah penderita diabetes menjadi salah satu faktor penyebab semakin tingginya penderita penyakit <em>diabetic retinophaty</em>. Salah satu citra yang digunakan oleh dokter mata untuk mengidentifikasi <em>diabetic retinophaty</em> adalah foto retina. Dalam penelitian ini dilakukan pengenalan penyakit diabetic retinophaty secara otomatis menggunakan citra <em>fundus</em> retina dan algoritme <em>Convolutional Neural Network</em> (CNN) yang merupakan variasi dari algoritme Deep Learning. Kendala yang ditemukan dalam proses pengenalan adalah warna retina yang cenderung merah kekuningan sehingga ruang warna RGB tidak menghasilkan akurasi yang optimal. Oleh karena itu, dalam penelitian ini dilakukan pengujian pada berbagai ruang warna untuk mendapatkan hasil yang lebih baik. Dari hasil uji coba menggunakan 1000 data pada ruang warna RGB, HSI, YUV dan L*a*b* memberikan hasil yang kurang optimal pada data seimbang dimana akurasi terbaik masih dibawah 50%. Namun pada data tidak seimbang menghasilkan akurasi yang cukup tinggi yaitu 83,53% pada ruang warna YUV dengan pengujian pada data latih dan akurasi 74,40% dengan data uji pada semua ruang warna.</p><p> </p><p><em><strong>Abstract</strong></em></p><p class="Abstract"><em>Increasing the number of people with diabetes is one of the factors causing the high number of people with diabetic retinopathy. One of the images used by ophthalmologists to identify diabetic retinopathy is a retinal photo. In this research, the identification of diabetic retinopathy is done automatically using retinal fundus images and the Convolutional Neural Network (CNN) algorithm, which is a variation of the Deep Learning algorithm. The obstacle found in the recognition process is the color of the retina which tends to be yellowish red so that the RGB color space does not produce optimal accuracy. Therefore, in this research, various color spaces were tested to get better results. From the results of trials using 1000 images data in the color space of RGB, HSI, YUV and L * a * b * give suboptimal results on balanced data where the best accuracy is still below 50%. However, the unbalanced data gives a fairly high accuracy of 83.53% with training data on the YUV color space and 74,40% with testing data on all color spaces.</em></p><p><em><strong><br /></strong></em></p>

scholarly journals Using a Deep Learning Algorithm and Integrated Gradients Explanation to Assist Grading for Diabetic Retinopathy

Ophthalmology ◽  
2019 ◽  
Vol 126 (4) ◽  
pp. 552-564 ◽  
Author(s):  
Rory Sayres ◽  
Ankur Taly ◽  
Ehsan Rahimy ◽  
Katy Blumer ◽  
David Coz ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Learning Algorithm ◽  
Deep Learning Algorithm

Real-world application of Spirometry Quality Control Deep-Learning Algorithm

2021 ◽  
Author(s):  
Sanja Stanojevic ◽  
Pippa Powell ◽  
Graham Hall ◽  
Marko Topalovic ◽  
Nilakash Das ◽  
...  
Keyword(s):  
Quality Control ◽  
Deep Learning ◽  
Real World ◽  
Learning Algorithm ◽  
Deep Learning Algorithm ◽  
Real World Application

scholarly journals Performance of a Deep-Learning Algorithm vs Manual Grading for Detecting Diabetic Retinopathy in India

2019 ◽  
Vol 137 (9) ◽  
pp. 987 ◽  
Author(s):  
Varun Gulshan ◽  
Renu P. Rajan ◽  
Kasumi Widner ◽  
Derek Wu ◽  
Peter Wubbels ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Learning Algorithm ◽  
Deep Learning Algorithm

scholarly journals Screening Referable Diabetic Retinopathy Using a Semi-automated Deep Learning Algorithm Assisted Approach

2021 ◽  
Vol 8 ◽  
Author(s):  
Yueye Wang ◽  
Danli Shi ◽  
Zachary Tan ◽  
Yong Niu ◽  
Yu Jiang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Sensitivity And Specificity ◽  
Learning Algorithm ◽  
Characteristic Curve ◽  
Economic Cost ◽  
Positive Image ◽  
Deep Learning Algorithm ◽  
Image Datasets

Purpose: To assess the accuracy and efficacy of a semi-automated deep learning algorithm (DLA) assisted approach to detect vision-threatening diabetic retinopathy (DR).Methods: We developed a two-step semi-automated DLA-assisted approach to grade fundus photographs for vision-threatening referable DR. Study images were obtained from the Lingtou Cohort Study, and captured at participant enrollment in 2009–2010 (“baseline images”) and annual follow-up between 2011 and 2017. To begin, a validated DLA automatically graded baseline images for referable DR and classified them as positive, negative, or ungradable. Following, each positive image, all other available images from patients who had a positive image, and a 5% random sample of all negative images were selected and regraded by trained human graders. A reference standard diagnosis was assigned once all graders achieved consistent grading outcomes or with a senior ophthalmologist's final diagnosis. The semi-automated DLA assisted approach combined initial DLA screening and subsequent human grading for images identified as high-risk. This approach was further validated within the follow-up image datasets and its time and economic costs evaluated against fully human grading.Results: For evaluation of baseline images, a total of 33,115 images were included and automatically graded by the DLA. 2,604 images (480 positive results, 624 available other images from participants with a positive result, and 1500 random negative samples) were selected and regraded by graders. The DLA achieved an area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy of 0.953, 0.970, 0.879, and 88.6%, respectively. In further validation within the follow-up image datasets, a total of 88,363 images were graded using this semi-automated approach and human grading was performed on 8975 selected images. The DLA achieved an AUC, sensitivity, and specificity of 0.914, 0.852, 0.853, respectively. Compared against fully human grading, the semi-automated DLA-assisted approach achieved an estimated 75.6% time and 90.1% economic cost saving.Conclusions: The DLA described in this study was able to achieve high accuracy, sensitivity, and specificity in grading fundus images for referable DR. Validated against long-term follow-up datasets, a semi-automated DLA-assisted approach was able to accurately identify suspect cases, and minimize misdiagnosis whilst balancing safety, time, and economic cost.

Deep Learning-Based Diabetic Retinopathy Detection

2021 ◽  
Vol 11 (3) ◽  
pp. 38-48
Author(s):  
Mohamed Jebran P. ◽  
Sufia Banu
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Learning Algorithm ◽  
Classification Performance ◽  
Learning Problems ◽  
Deep Learning Algorithm ◽  
Lesion Level ◽  
Fundus Photographs

Artificial intelligence (AI) is rapidly evolving from machine learning (ML) to deep learning (DL), which has ignited particular interest in ophthalmology as well. Deep learning has been applied in ophthalmology to fundus photographs, which achieve robust classification performance in the detection of diabetic retinopathy (DR). Diabetic retinopathy is a progressive condition observed in people who have had multiple years of diabetes mellitus. This paper focuses on examining how a deep learning algorithm can be applied for the detection and classification of diabetic retinopathy, both at the image level and at the lesion level. The performance of various neural networks is summarized by taking into account the sensitivity, precision, accuracy with respect to the size of the test datasets. Deep learning problems are discussed at the end.

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