scholarly journals Association between oral leukoplakia and risk of upper gastrointestinal cancer death: A follow-up study of the Linxian General Population Trial

2017 ◽  
Vol 8 (6) ◽  
pp. 642-648 ◽  
Author(s):  
He Liang ◽  
Zhao Yang ◽  
Jian-Bing Wang ◽  
Pei Yu ◽  
Jin-Hu Fan ◽  
...  
Keyword(s):  
General Population ◽  
Gastrointestinal Cancer ◽  
Oral Leukoplakia ◽  
Cancer Death ◽  
Follow Up Study ◽  
Upper Gastrointestinal Cancer ◽  
Upper Gastrointestinal

scholarly journals The marginal causal effect of opium consumption on the upper gastrointestinal cancer death using parametric g-formula: An analysis of 49,946 cases in the Golestan Cohort Study, Iran

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0246004
Author(s):  
Neda Mohammadi ◽  
Masoomeh Alimohammadian ◽  
Akbar Feizesani ◽  
Hossein Poustchi ◽  
Ahad Alizadeh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Gastrointestinal Cancer ◽  
Causal Effect ◽  
Population Attributable Fraction ◽  
Cancer Death ◽  
Adjusted Risk ◽  
Upper Gastrointestinal Cancer ◽  
Upper Gastrointestinal ◽  
Opium Use

Upper gastrointestinal (UGI) cancer, including esophageal and gastric, is one of the most common cancers in the world. Hence, the determination of risk factors of UGI helps to reduce the economic and social burden of this cancer in communities. In Iran, the consumption of opium because of its neighborhood with Afghanistan are considerable. In this study, we examine the causal effect of opium use on the time to UGI cancer death. Based on the Golestan Cohort Study (GCS) in northeastern of Iran, about 50000 adults were enrolled to the study for four years (2004–2008) and followed annually until July 2018. We used “parametric g-formula” to study the causal effect of opium use on the time to death due to UGI. In this study, the information of 49946 individuals due to missingness were analyzed. So the median of follow-up time was 144 months and the prevalence of opium use was 17% (about 8489 persons). During the follow-up period, 593 (1.2%) death from upper gastrointestinal cancer were reported. The study showed that the effect of opium use on the time to UGI death was statistically significant (adjusted risk-ratio based on parametric g-formula = 1.31, 95% CI: [1.04, 1.65]). Additionally, the Population Attributable Fraction (PAF) in UGI cancer deaths of opium use was estimated 5.3% (95% CI: [0.6%, 11.3%]). Our results showed a causal effect of opium use on the intensity of upper gastrointestinal cancer death.

scholarly journals Nurse-Led Follow-Up at Home vs. Conventional Medical Outpatient Clinic Follow-Up in Patients With Incurable Upper Gastrointestinal Cancer: A Randomized Study

2014 ◽  
Vol 47 (3) ◽  
pp. 518-530 ◽  
Author(s):  
Madeleen J. Uitdehaag ◽  
Paul G. van Putten ◽  
Casper H.J. van Eijck ◽  
Els M.L. Verschuur ◽  
Ate van der Gaast ◽  
...  
Keyword(s):  
Outpatient Clinic ◽  
Gastrointestinal Cancer ◽  
Randomized Study ◽  
Upper Gastrointestinal Cancer ◽  
Upper Gastrointestinal ◽  
At Home

scholarly journals Predictive values of upper gastrointestinal cancer alarm symptoms in the general population: a nationwide cohort study

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Sanne Rasmussen ◽  
Peter Fentz Haastrup ◽  
Kirubakaran Balasubramaniam ◽  
René DePont Christensen ◽  
Jens Søndergaard ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Gastrointestinal Cancer ◽  
Predictive Values ◽  
Upper Gastrointestinal Cancer ◽  
Upper Gastrointestinal

Prognostic significance of LINE-1 methylation level in the upper gastrointestinal cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 10523-10523
Author(s):  
Yoshifumi Baba ◽  
Masayuki Watanabe ◽  
Shiro Iwagami ◽  
Hironobu Shigaki ◽  
Takatsugu Ishimoto ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gastrointestinal Cancer ◽  
Methylation Level ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Dna Hypomethylation ◽  
Cancer Specific Survival ◽  
Upper Gastrointestinal Cancer ◽  
Upper Gastrointestinal

10523 Background: Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. DNA methylation in long interspersed nucleotide element-1 (LINE-1) is a good indicator of global DNA methylation level. Although LINE-1 methylation level is attracting interest as a useful marker for predicting cancer prognosis, the prognostic significance of LINE-1 hypomethylaiton in the upper gastrointestinal cancer [i.e., esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC)] remains unclear. Methods: Using 217 ESCC and 207 GC specimens, we quantified the LINE-1 methylation using bisulfite-pyrosequencing technology. During the follow-up, there were a total of 63 ESCC recurrences, 51 ESCC deaths and 56 GC deaths. The median follow-up time for censored patients was 2.8 years. A Cox proportional hazards model was used to calculate the hazard ratio (HR), adjusted for the clinical, epidemiological, and pathological variables. The term “prognostic marker” is used throughout this study according to the REMARK Guidelines. Results: ESCCs and GCs showed significantly lower LINE-1 methylation levels compared to matched normal mucosa (p<0.0001). In ESCC, LINE-1 hypomethylation was significantly associated with disease-free survival [log-rank p=0.0008; univariate HR= 2.32, 95% confidence interval (CI) 1.38-3.84, p=0.0017; multivariate HR=1.81, 95% CI 1.06-3.05, p=0.031] and cancer-specific survival (log-rank p=0.0020; univariate HR=2.21, 95% CI 1.33-3.60, p=0.0026; multivariate HR=1.87, 95% CI 1.12-3.08, p=0.018]. We found a significant modifying effect of the tumor stage on the relationship between LINE-1 methylation and the recurrence rate (P for interaction = 0.031). In GC, LINE-1 hypomethylation was significantly associated with cancer-specific survival (log-rank p=0.029; univariate HR=2.01, 95% CI 1.09-3.99). Conclusions: LINE-1 hypomethylation is associated with shorter survival in both ESCC and GC, suggesting that it has potential for use as a prognostic biomarker.

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