scholarly journals Life‐threatening extrapleural hematoma in an anticoagulated patient 2 weeks after lobectomy

2021 ◽  
Author(s):  
Masanori Shimomura ◽  
Masashi Iwasaki ◽  
Reona Shimegi ◽  
Masayoshi Inoue
Keyword(s):  
Extrapleural Hematoma ◽  
Life Threatening ◽  
Anticoagulated Patient

scholarly journals High Risk of Venous Thrombosis Recurrence in Fully Anticoagulated Patient with Antithrombin Deficiency during COVID-19: A Case Report

2021 ◽  
Author(s):  
Mirjana Kovac ◽  
Olivera Markovic ◽  
Sanja Lalic-Cosic ◽  
Gorana Mitic
Keyword(s):  
Thrombotic Event ◽  
Type Ii ◽  
Heparin Binding ◽  
Antithrombin Deficiency ◽  
Acute Thrombosis ◽  
Vein Thrombosis ◽  
Number Of Patients ◽  
Life Threatening ◽  
Anticoagulated Patient ◽  
Thrombotic Complications

AbstractCoagulation dysfunction is a serious issue in patients with Coronavirus disease-19 (COVID-19). With regard to recently published studies, a high number of patients with acute respiratory distress syndrome (ARDS) secondary to COVID-19 developed life-threatening thrombotic complications despite anticoagulation. We report a case of young woman with the type-II heparin-binding site (HBS) antithrombin (AT) deficiency (Budapest 3-homozygous), who developed acute deep vein thrombosis on two occasions due to COVID-19 infection in the course of stable anticoagulation with vitamin K antagonist. The first thrombotic event was observed during mild COVID-19 infection, while the second thrombotic event she developed 2 months after she was negative for severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2). Our case highlights the complexity of the treatment in this particular type of thrombophilia and the need for precaution even in mild forms of viral infection. In the treatment of acute thrombosis, AT-deficient patients may benefit from the use of AT concentrate along with low-molecular weight heparin (LMWH), while in cases of type II-HBS, AT supplementation is mandatory.

scholarly journals Two extremely rare cases of extrapleural hematoma

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Soichi Oka ◽  
Kenji Ono ◽  
Kenta Kajiyama ◽  
Katsuma Yoshimatsu
Keyword(s):  
Anticoagulation Therapy ◽  
Thoracic Cavity ◽  
Close Attention ◽  
Case Presentation ◽  
Extrapleural Hematoma ◽  
Disturbance Of Consciousness ◽  
History Of ◽  
Anticoagulated Patient ◽  
The Right ◽  
Circulatory Disturbances

Abstract Background Extrapleural hematoma is uncommon. However, according to the size of hematoma and/or the progression of anemia, surgical treatment to control bleeding might be necessary because a huge hematoma can cause ventilator and circulatory disturbances to press heart and lung. We present two unusual cases of huge extrapleural hematoma in an anticoagulated patient with no apparent history of trauma or otherwise traumatic episodes. Case presentation Case 1: A 78-year-old man presented to our emergency department with pain in his right shoulder and disturbance of consciousness. He had no apparent history of trauma. Computed tomography (CT) of the chest revealed the presence of a huge lens-like encapsulated lesion measuring 220 × 90 mm in the right thoracic cavity. These findings all supported a diagnosis of extrapleural hematoma with hemothorax. Case 2: A 73-year-old man was brought to our hospital by ambulance after bruising his back in his house. CT of the chest revealed the presence of a huge lens-like encapsulated lesion measuring 230 × 70 mm in the left thoracic cavity. Hemorrhagic effusion was obtained by thoracocentesis, and the lesion was suspected of being a hematoma. In both two cases, we performed video-assisted thoracic surgery (VATS), which was minimally invasive and effective. These two patients were cured and discharged smoothly after surgery. Conclusions We reported two rare cases of extrapleural hematoma. This disease requires close attention when it manifests in patients undergoing anticoagulation therapy. Regarding treatment, VATS was particularly effective in these cases.

Huge extrapleural hematoma in an anticoagulated patient

2007 ◽  
Vol 55 (4) ◽  
pp. 174-176 ◽  
Author(s):  
Hitoshi Sumida ◽  
Nobuhiro Ono ◽  
Yasuji Terada
Keyword(s):  
Extrapleural Hematoma ◽  
Anticoagulated Patient

scholarly journals Spontaneous Epiglottic Hematoma Secondary to Supratherapeutic Anticoagulation

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Cody A. Koch ◽  
Steven M. Olsen ◽  
Amy M. Saleh ◽  
Laura J. Orvidas
Keyword(s):  
Soft Tissues ◽  
Upper Airway ◽  
Airway Compromise ◽  
Life Threatening ◽  
Anticoagulated Patient ◽  
Life Threatening Complication ◽  
Spontaneous Hematoma

Hemorrhage into the soft tissues of the airway represents a potentially life-threatening complication of long-term anticoagulation. We report the case of a chronically anticoagulated 37-year-old male who developed a spontaneous hematoma of the epiglottis secondary to a supra-therapeutic INR. Epiglottic hematoma should be considered in the differential of any anticoagulated patient presenting with upper airway compromise. The airway should be secured in a controlled fashion, and the coagulopathy should be rapidly corrected.

scholarly journals Beware of Reversal of an Anticoagulated Patient with Factor IX in the Emergency Department: Case Report of a Medical-Legal Misadventure

2020 ◽  
Vol 4 (1) ◽  
pp. 12-15
Author(s):  
Steven Gannon ◽  
David Bell ◽  
Kenneth Jackmiczyk ◽  
Gregory Moore
Keyword(s):  
Myocardial Infarction ◽  
Decision Making ◽  
Emergency Department ◽  
Anticoagulation Therapy ◽  
Factor Ix ◽  
Direct Result ◽  
Shared Decision ◽  
Life Threatening ◽  
Anticoagulated Patient ◽  
Attending Physician

In this article we present a case of a patient who received reversal of anticoagulation therapy with factor IX in violation of hospital guidelines. As a direct result, myocardial infarction and ischemic stroke occurred, leaving the patient neurologically debilitated. Factor IX is indicated in the setting of warfarin-induced, life-threatening bleeding. The patient’s care was provided by an intern with attending physician supervision. Delayed charting and questionable shared decision-making were present in the care. We discuss usage of factor IX, liability for supervision of physicians in training, and factors that can lead to plaintiff awards.

scholarly journals Management of Life-Threatening Arterial Hemorrhage Following a Fragility Fracture of the Pelvis in the Anticoagulated Patient

2016 ◽  
Vol 7 (3) ◽  
pp. 163-167 ◽  
Author(s):  
Christian David Weber ◽  
Christian Herren ◽  
Thomas Dienstknecht ◽  
Frank Hildebrand ◽  
Sebastian Keil ◽  
...  
Keyword(s):  
Fragility Fracture ◽  
Arterial Hemorrhage ◽  
Life Threatening ◽  
Anticoagulated Patient

Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

1995 ◽  
Vol 53 ◽  
pp. 840-841
Author(s):  
Z. Hong Zhou ◽  
Jing He ◽  
Joanita Jakana ◽  
J. D. Tatman ◽  
Frazer J. Rixon ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
3D Structure ◽  
Structure Study ◽  
Herpes Simplex Virus 1 ◽  
Shell Proteins ◽  
Life Threatening ◽  
Infected Cells ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

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