The Influence of Age on the Diagnostic Performance of White Blood Cell Count and Absolute Neutrophil Count in Suspected Pediatric Appendicitis

2016 ◽  
Vol 23 (11) ◽  
pp. 1235-1242 ◽  
Author(s):  
Richard G. Bachur ◽  
Peter S. Dayan ◽  
Nanette C. Dudley ◽  
Lalit Bajaj ◽  
Michelle D. Stevenson ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Absolute Neutrophil Count ◽  
Neutrophil Count ◽  
Diagnostic Performance ◽  
Blood Cell Count

scholarly journals Clinical Characteristics and Prognosis of Patients with COVID-19 Combineded with or without Diabetes, Hypertension or Coronary

2020 ◽  
Author(s):  
Haoxiang Li ◽  
Jianguo Zhang ◽  
Jinhui Zhang ◽  
Ling Yang ◽  
Dong Wang ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Blood Cell ◽  
Cell Count ◽  
Chronic Diseases ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Neutrophil Count ◽  
Blood Cell Count ◽  
Neutrophil Percentage ◽  
D Dimer

Abstract Bcakground: This study was to investigate the clinical characteristics and prognosis of COVID-19 patients combined with or without major chronic diseases like diabetes, hypertension or coronary. Methods: We retrospectively analyzed 183 patients with COVID-19 diagnosed at First People's Hospital of Jiangxia District (FPHJD) in Wuhan, China attended by Affiliated Hospital of Jiangsu University supporting medical team from February 1, 2020 to March 15, 2020. Patients were divided into simple COVID-19 group(n=134), COVID-19 combined with diabetes, hypertension or coronary group(n=49). Besides, COVID-19 patients with diabetes, hypertension or coronary were further classified into severe pneumonia group(n=23) and common pneumonia group(n=26), death group(n=17) and survival group(n=32). The prognosis of COVID-19 patients was evaluated by analyzing the clinical data and the results of laboratory tests. Results: 183 patients were included in this study, of whom 166 were discharged and 16 died in hospital. 49 (26.92%) patients had a comorbidity, with hypertension being the most common [37 (20.33%) patients], followed by diabetes [25 (13.74%) patients] and coronary heart disease [4 (2.2%) patients]. Compared with simple COVID-19 group, the proportion of history of chronic respiratory system disease, age, D-dimer, procalcitonin, C-reactive protein, myoglobin, cardiac troponin I, creatine kinase MB, lactate dehydrogenase, white blood cell count, neutrophil count, neutrophil percentage, blood urea nitrogen, creatinine and mortality rate were significantly higher in COVID-19 combined with chronic diseases group, whereas lymphocyte count, lymphocyte percentage and alanine transferase were significantly lower in COVID-19 combined with chronic diseases group. Among COVID-19 patients with chronic diseases, D-dimer, procalcitonin, C-reactive protein, myoglobin, cardiac troponin I, lactate dehydrogenase, white blood cell count, neutrophil count, neutrophil percentage, blood urea nitrogen, death rate was significantly higher in severe pneumonia group than common pneumonia group. While lymphocyte count and lymphocyte percentage were significantly lower in severe pneumonia group than common pneumonia group. Besides, we found that the proportion of history of chronic respiratory system disease, D-dimer, procalcitonin, myoglobin, cardiac troponin I, creatine kinase MB, lactate dehydrogenase, neutrophil count, neutrophil percentage, blood urea nitrogen were significantly higher in death group compared with survival group, whereas lymphocyte count and lymphocyte percentage were significantly lower in survival group. In COVID-19 combined with chronic diseases group, univariate logistic regression showed that the risk for severe pneumonia were D-dimer, C-reactive protein, lactate dehydrogenase, white blood cell count, neutrophil count and neutrophil percentage. Univariate logistic regression also showed that the risk for death were D-dimer, lactate dehydrogenase, white blood cell count, neutrophil count, neutrophil percentage and blood urea nitrogen. Multivariate regression logistic showed that lactate dehydrogenase were independent risk factors for death among COVID-19 patients combined with chronic diseases. Cox regression analysis showed that compared with simple COVID-19 group, the RR(95% CI) in COVID-19 patients combined with diabetes, hypertension, and coronary were 2.187 (1.141~4.191) for death (P<0.05). Conclusion: Among COVID-19 patients combined with diabetes, hypertension or coronary, the risk factors for severe pneumonia were D-dimer, C-reactive protein, lactate dehydrogenase, white blood cell count, neutrophil count and neutrophil percentage, whereas the risk factors for death were D-dimer, lactate dehydrogenase, white blood cell count, neutrophil count, neutrophil percentage and blood urea nitrogen. Moreover, lactate dehydrogenase were independent risk factors for death. The mortality rate of COVID-19 patients combined with diabetes, hypertension or coronary was higher than that of simple COVID-19 patients.

scholarly journals Clinical characteristics of 101 COVID-19 nonsurvivors in Wuhan, China: a retrospective study

2020 ◽  
Author(s):  
Qiao Shi ◽  
Kailiang Zhao ◽  
Jia Yu ◽  
Fang Jiang ◽  
Jiarui Feng ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Neutrophil Count ◽  
Medical Records ◽  
Cardiac Injury ◽  
Kidney Injury ◽  
Blood Cell Count ◽  
Disease Progress

BackgroundThe outbreak of COVID-19 has aroused global concerns. Few studies focused on characteristics of COVID-19 nonsurvivors.ObjectiveIn this study, we aimed to describe the clinical characteristics of 101 nonsurvivors with COVID-19 and analyze risk factors associated with the rapid disease progress to death after admission.DesignRetrospective study using electronic medical records.Participants101 hospitalized patients with confirmed COVID-19 died in Renmin Hospital of Wuhan University before February 15, 2020, were included in this study.Main measuresWe obtained epidemiological, demographic, clinical, laboratory, and outcome data from electronic medical records. Univariate logistic regression analyses were performed to evaluate risk factors associated with rapid disease progress to death after admission.Key resultsAmong included nonsurvivors, the median age was 71.0 years (IQR, 59.0-80.0), 60 (59.4%) were men. Eighty-two (79.2%) had one or more comorbidities including hypertension (58.4%), diabetes (21.8%) etc. Respiratory failure (99.0%), acute cardiac injury (52.5%), sepsis (40.6%) and acute kidney injury (22.8%) were most common complications. Patients died within 3 days of admission were more likely to develop sepsis compared with those survived 3 days of admission. Higher heart rate and respiration rate, increased white blood cell count and neutrophil count, elevated myoglobin level and depressed oxygen saturation on admission were associated with rapid disease progress to death within 3 days of admission. The AUCs for white blood cell count and neutrophil count were 0.71 (95% CI, 0.60-0.80) and 0.70 (95% CI, 0.59-0.79), respectively.ConclusionsOlder patients with underlying comorbidities suffering COVID-19 were at increased risks of death. Respiratory failure, acute cardiac injury and acute kidney injury played crucial roles in the death of COVID-19 patients. Of importance, early development of sepsis, increased white blood cell count and neutrophil count on admission were associated with the rapid disease progress to death.

scholarly journals White Blood Cell Count, Especially Neutrophil Count, as a Predictor of Hypertension in a Japanese Population

2008 ◽  
Vol 31 (7) ◽  
pp. 1391-1397 ◽  
Author(s):  
Yoshimi TATSUKAWA ◽  
Wan-Ling HSU ◽  
Michiko YAMADA ◽  
John B. COLOGNE ◽  
Gen SUZUKI ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Neutrophil Count ◽  
Japanese Population ◽  
Blood Cell Count
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