scholarly journals Effective Reduction in High Ethanol Drinking by Semisynthetic Tetracycline Derivatives

2016 ◽  
Vol 40 (12) ◽  
pp. 2482-2490 ◽  
Author(s):  
Peter J. Syapin ◽  
Joseph M. Martinez ◽  
David C. Curtis ◽  
Patrick C. Marquardt ◽  
Clayton L. Allison ◽  
...  
Keyword(s):  
Ethanol Drinking ◽  
Effective Reduction ◽  
High Ethanol

Ethanol Palatability and Consumption by High Ethanol-Drinking Rats: Manipulation of the Opioid System With Naltrexone.

2004 ◽  
Vol 118 (5) ◽  
pp. 1089-1096 ◽  
Author(s):  
Daniel L. Coonfield ◽  
Stephen W. Kiefer ◽  
Frank M. Ferraro ◽  
John David Sinclair
Keyword(s):  
Opioid System ◽  
Ethanol Drinking ◽  
High Ethanol

scholarly journals Bioinformatics Analyses Reveal Age-Specific Neuroimmune Modulation as a Target for Treatment of High Ethanol Drinking

2013 ◽  
Vol 38 (2) ◽  
pp. 428-437 ◽  
Author(s):  
Rajiv G. Agrawal ◽  
Julie A. Owen ◽  
Patricia S. Levin ◽  
Aveline Hewetson ◽  
Ari E. Berman ◽  
...  
Keyword(s):  
Bioinformatics Analyses ◽  
Ethanol Drinking ◽  
Neuroimmune Modulation ◽  
High Ethanol

Activation of Melanocortin-4 Receptor by a Synthetic Agonist Inhibits Ethanolinduced Neuroinflammation in Rats

2020 ◽  
Vol 25 (45) ◽  
pp. 4799-4805 ◽  
Author(s):  
Osvaldo Flores-Bastías ◽  
Gonzalo I. Gómez ◽  
Juan A. Orellana ◽  
Eduardo Karahanian
Keyword(s):  
Prefrontal Cortex ◽  
Alcohol Consumption ◽  
Ethanol Intake ◽  
Neuroinflammatory Response ◽  
Agonist Peptide ◽  
Melanocortin 4 Receptor ◽  
Tnf Α ◽  
Cord Injury ◽  
High Ethanol ◽  
The Brain

Background: High ethanol intake induces a neuroinflammatory response resulting in the subsequent maintenance of chronic alcohol consumption. The melanocortin system plays a pivotal role in the modulation of alcohol consumption. Interestingly, it has been shown that the activation of melanocortin-4 receptor (MC4R) in the brain decreases the neuroinflammatory response in models of brain damage other than alcohol consumption, such as LPS-induced neuroinflammation, cerebral ischemia, glutamate excitotoxicity, and spinal cord injury. Objectives: In this work, we aimed to study whether MC4R activation by a synthetic MC4R-agonist peptide prevents ethanol-induced neuroinflammation, and if alcohol consumption produces changes in MC4R expression in the hippocampus and hypothalamus. Methods: Ethanol-preferring Sprague Dawley rats were selected offering access to 20% ethanol on alternate days for 4 weeks (intermittent access protocol). After this time, animals were i.p. administered an MC4R agonist peptide in the last 2 days of the protocol. Then, the expression of the proinflammatory cytokines interleukin 6 (IL-6), interleukin 1-beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) were measured in the hippocampus, hypothalamus and prefrontal cortex. It was also evaluated if ethanol intake produces alterations in the expression of MC4R in the hippocampus and the hypothalamus. Results: Alcohol consumption increased the expression of MC4R in the hippocampus and the hypothalamus. The administration of the MC4R agonist reduced IL-6, IL-1β and TNF-α levels in hippocampus, hypothalamus and prefrontal cortex, to those observed in control rats that did not drink alcohol. Conclusion: High ethanol consumption produces an increase in the expression of MC4R in the hippocampus and hypothalamus. The administration of a synthetic MC4R-agonist peptide prevents neuroinflammation induced by alcohol consumption in the hippocampus, hypothalamus, and prefrontal cortex. These results could explain the effect of α-MSH and other synthetic MC4R agonists in decreasing alcohol intake through the reduction of the ethanol-induced inflammatory response in the brain.

The contribution of medium spiny neuron subtypes in the nucleus accumbens core to compulsive-like ethanol drinking

2021 ◽  
Vol 187 ◽  
pp. 108497 ◽  
Author(s):  
Elizabeth A. Sneddon ◽  
Kristen M. Schuh ◽  
John W. Frankel ◽  
Anna K. Radke
Keyword(s):  
Nucleus Accumbens ◽  
Medium Spiny Neuron ◽  
Nucleus Accumbens Core ◽  
Ethanol Drinking ◽  
Accumbens Core

scholarly journals Effective Reduction of Oxygen Debris in Graphene Oxide

2021 ◽  
Vol 258 (3) ◽  
pp. 2170015
Author(s):  
Orit Seri-Livni ◽  
Cecile Saguy ◽  
Faris Horani ◽  
Efrat Lifshitz ◽  
Dima Cheskis
Keyword(s):  
Graphene Oxide ◽  
Effective Reduction

Development of an ethanolic two-phase system (ETPS) based on polypropylene glycol 2000 + ethylene glycol + ethanol for separation of hydrophobic compounds

2021 ◽  
Author(s):  
Filipe Smith Buarque ◽  
Cleide Mara Faria Soares ◽  
Ranyere Lucena de Souza ◽  
Matheus Mendonça Pereira ◽  
Álvaro Silva Lima
Keyword(s):  
Ethylene Glycol ◽  
Phase System ◽  
Polypropylene Glycol ◽  
Two Phase ◽  
Hydrophobic Compounds ◽  
Ethanol Content ◽  
Coexisting Phases ◽  
Phase Water ◽  
High Ethanol

Two-phase water-free systems containing high ethanol content in the coexisting phases can selectively partition hydrophobic molecules from natural biomass.

A pre-injury high ethanol intake in rats promotes brain edema following traumatic brain injury

2014 ◽  
Vol 28 (6) ◽  
pp. 739-745 ◽  
Author(s):  
Weichuan Wu ◽  
Runfa Tian ◽  
Shuyu Hao ◽  
Feifan Xu ◽  
Xiang Mao ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Edema ◽  
Ethanol Intake ◽  
High Ethanol

scholarly journals β-Glucosidase Activity of Lactiplantibacillus plantarum UNQLp 11 in Different Malolactic Fermentations Conditions: Effect of pH and Ethanol Content

Fermentation ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. 22
Author(s):  
Natalia S. Brizuela ◽  
Marina Arnez-Arancibia ◽  
Liliana Semorile ◽  
María Ángeles Pozo-Bayón ◽  
Bárbara M. Bravo-Ferrada ◽  
...  
Keyword(s):  
Pinot Noir ◽  
Gas Chromatography Mass Spectrometry ◽  
Red Wines ◽  
Ph Values ◽  
Glucosidase Activity ◽  
Sorptive Extraction ◽  
Ethanol Content ◽  
Volatile Precursors ◽  
Hydrolysis Of ◽  
High Ethanol

Lactiplantibacillus plantarum strain UNQLp 11 is a lactic acid bacterium with the potential to carry out malolactic fermentation (MLF) in red wines. Recently, the complete genome of UNQLp 11 was sequenced and this strain possesses four loci of the enzyme β-glucosidase. In order to demonstrate that these glucosidase enzymes could be functional under harsh wine conditions, we evaluated the hydrolysis of p-nitrophenyl-β-D-glucopyranoside (p-NPG) in synthetic wine with different ethanol contents (0%, 12%, and 14% v/v) and at different pH values (3.2, 3.5, and 3.8). Then, the hydrolysis of precursor n-octyl β-D-glucopyranoside was analyzed in sterile Pinot Noir wine (containing 14.5% v/v of ethanol, at different pH values) by headspace sorptive extraction gas chromatography-mass spectrometry (HSSE-GC/MS). The hydrolysis of p-NPG showed that β-glucosidase activity is very susceptible to low pH but induced in the presence of high ethanol content. Furthermore, UNQLp 11 was able to release the glycosilated precursor n-octyl, during MLF to a greater extent than a commercial enzyme. In conclusion, UNQLp 11 could improve the aromatic profile of the wine by the release of volatile precursors during MLF.

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