scholarly journals Sex Differences in Photic Entrainment and Sensitivity to Ethanol-Induced Chronodisruption in Adult Mice After Adolescent Intermittent Ethanol Exposure

2018 ◽  
Vol 42 (11) ◽  
pp. 2144-2159 ◽  
Author(s):  
Christina L. Ruby ◽  
Gerneleh Paye ◽  
Jason L. Fabi ◽  
Jiawen Zhang ◽  
Megan O. Risinger ◽  
...  
Keyword(s):  
Sex Differences ◽  
Ethanol Exposure ◽  
Photic Entrainment ◽  
Adult Mice

scholarly journals Fetal/neonatal ethanol exposure irreversibly alters dendritic cell function in adult mice

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Ji Fan ◽  
Annette Schlueter
Keyword(s):  
Dendritic Cell ◽  
Cell Function ◽  
Ethanol Exposure ◽  
Dendritic Cell Function ◽  
Adult Mice

scholarly journals Androgen regulation of bowel function in mice and humans

2020 ◽  
Author(s):  
Daniella Rastelli ◽  
Ariel Robinson ◽  
Lynley T. Matthews ◽  
Kristina Perez ◽  
William Dan ◽  
...  
Keyword(s):  
Sex Differences ◽  
Smooth Muscle ◽  
Colonic Motility ◽  
Bowel Function ◽  
Free Testosterone ◽  
Enteric Neurons ◽  
Adult Mice ◽  
Digestive Disorder ◽  
Irritable Bowel

SummaryMany digestive disorders have prominent sex differences in incidence, symptomatology, and treatment response that are not well understood. Irritable bowel syndrome (IBS), for example, affects approximately 10% of the population worldwide and tends to have different manifestations in males and females. Androgens are steroid hormones present at much higher levels in post-pubertal males than females and could be involved in these sex differences, but their normal functions in the bowel are largely unknown. Here, we show that gonadal androgens are required for normal gastrointestinal motility in vivo. In the healthy mouse gut, we detected androgen receptors in smooth muscle cells and a subset of enteric neurons. Surgical or genetic disruption of androgen signaling in adult mice selectively and reversibly altered colonic motility by affecting neurons rather than smooth muscle. To determine if androgens also influence human bowel function, we measured androgen levels in 208 adults with IBS. Free testosterone levels were lower in patients with IBS compared to healthy controls and inversely correlated with symptom severity. Taken together, these observations establish a role for androgens in the regulation of colonic motility and link altered androgen signaling with a common digestive disorder. These findings advance the fundamental understanding of gut motility, with implications for normal aging and disorders involving the gut-brain axis.

scholarly journals Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation

2016 ◽  
Vol 67 (4) ◽  
pp. 297-303 ◽  
Author(s):  
Ranko Stojković ◽  
Aleksandra Fucic ◽  
Dušica Ivanković ◽  
Zoran Jukić ◽  
Petra Radulović ◽  
...  
Keyword(s):  
Sex Differences ◽  
Gamma Radiation ◽  
Age Groups ◽  
Micronucleus Assay ◽  
Ionising Radiation ◽  
Adult Mice ◽  
Biological Responses ◽  
Genome Damage ◽  
Age And Sex

Abstract The mechanisms that lead to sex and age differences in biological responses to exposure to ionising radiation and related health risks have still not been investigated to a satisfactory extent. The significance of sex hormones in the aetiology of radiogenic cancer types requires a better understanding of the mechanisms involved, especially during organism development. The aim of this study was to show age and sex differences in genome damage between prepubertal and adult mice after single exposure to gamma radiation. Genome damage was measured 24 h, 48 h, and 72 h after exposure of 3-week and 12-week old BALB/CJ mice to 8 Gy of gamma radiation using an in vivo micronucleus assay. There was a significantly higher genome damage in prepubertal than in adult animals of both sexes for all sampling times. Irradiation caused a higher frequency of micronuclei in males of both age groups. Our study confirms sex differences in the susceptibility to effects of ionising radiation in mice and is the first to show that such a difference occurs already at prepubertal age.

scholarly journals Sex Differences in Caffeine Neurotoxicity Following Chronic Ethanol Exposure and Withdrawal

2009 ◽  
Vol 44 (6) ◽  
pp. 567-574 ◽  
Author(s):  
T. R. Butler ◽  
K. J. Smith ◽  
J. N. Berry ◽  
L. J. Sharrett-Field ◽  
M. A. Prendergast
Keyword(s):  
Sex Differences ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Chronic Ethanol Exposure

scholarly journals Sex-Related Differences in Locomotion and Climbing of C57Bl/6NTac Mice in a Novel Environment

2019 ◽  
pp. S353-S359
Author(s):  
V. BORBÉLYOVÁ ◽  
K. JANIŠOVÁ ◽  
J. MYSLIVEČEK ◽  
V. RILJAK
Keyword(s):  
Sex Differences ◽  
Home Cage ◽  
Open Field Test ◽  
Standard Laboratory ◽  
Laboratory Mice ◽  
Behavioral Testing ◽  
Exact Role ◽  
Adult Mice ◽  
Dependent Activity ◽  
Spontaneous Behavior

Laboratory mice in standard laboratory cages, besides horizontal and vertical locomotor activity, spontaneously display cage-bar related activities such as cage-grid climbing. Although, grid-climbing activity is one of the major components of spontaneous home-cage behavior of mice, its exact role is not fully understood. This study aimed to describe the sex-differences in coping with novelty and in spontaneous behavior of laboratory mice concerning the cage-climbing activity in an observer-independent open field test. Adult mice of both sexes (C57Bl/6NTac) underwent behavioral testing in LABORAS system. Female mice travelled significantly longer distance (by 30 %, p<0.05) and showed higher grid-climbing activity (by 50 %, p<0.05) than males. Based on our results, the grid-climbing is a sex-dependent activity of mice, however, its exact role remains to be elucidated.

scholarly journals Chronic Ethanol Exposure Enhances Facial Stimulation-Evoked Mossy Fiber–Granule Cell Synaptic Transmission via GluN2A Receptors in the Mouse Cerebellar Cortex

2021 ◽  
Vol 15 ◽  
Author(s):  
Bing-Xue Li ◽  
Guang-Hui Dong ◽  
Hao-Long Li ◽  
Jia-Song Zhang ◽  
Yan-Hua Bing ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Cerebellar Cortex ◽  
Granule Cell ◽  
Mossy Fiber ◽  
Sensory Information ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Chronic Ethanol Exposure ◽  
Adult Mice

Sensory information is transferred to the cerebellar cortex via the mossy fiber–granule cell (MF–GC) pathway, which participates in motor coordination and motor learning. We previously reported that chronic ethanol exposure from adolescence facilitated the sensory-evoked molecular layer interneuron–Purkinje cell synaptic transmission in adult mice in vivo. Herein, we investigated the effect of chronic ethanol exposure from adolescence on facial stimulation-evoked MF–GC synaptic transmission in the adult mouse cerebellar cortex using electrophysiological recording techniques and pharmacological methods. Chronic ethanol exposure from adolescence induced an enhancement of facial stimulation-evoked MF–GC synaptic transmission in the cerebellar cortex of adult mice. The application of an N-methyl-D-aspartate receptor (NMDAR) antagonist, D-APV (250 μM), induced stronger depression of facial stimulation-evoked MF–GC synaptic transmission in chronic ethanol-exposed mice compared with that in control mice. Chronic ethanol exposure-induced facilitation of facial stimulation evoked by MF–GC synaptic transmission was abolished by a selective GluN2A antagonist, PEAQX (10 μM), but was unaffected by the application of a selective GluN2B antagonist, TCN-237 (10 μM), or a type 1 metabotropic glutamate receptor blocker, JNJ16259685 (10 μM). These results indicate that chronic ethanol exposure from adolescence enhances facial stimulation-evoked MF–GC synaptic transmission via GluN2A, which suggests that chronic ethanol exposure from adolescence impairs the high-fidelity transmission capability of sensory information in the cerebellar cortex by enhancing the NMDAR-mediated components of MF–GC synaptic transmission in adult mice in vivo.

Chronic ethanol exposure during adolescence alters the behavioral responsiveness to ethanol in adult mice

2012 ◽  
Vol 229 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Caroline Quoilin ◽  
Vincent Didone ◽  
Ezio Tirelli ◽  
Etienne Quertemont
Keyword(s):  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Chronic Ethanol Exposure ◽  
Adult Mice ◽  
Behavioral Responsiveness

scholarly journals Ethanol Exposure Induces Neonatal Neurodegeneration by Enhancing CB1R Exon1 Histone H4K8 Acetylation and Up-regulating CB1R Function causing Neurobehavioral Abnormalities in Adult Mice

2014 ◽  
Vol 18 (5) ◽  
pp. pyu028-pyu028 ◽  
Author(s):  
S. Subbanna ◽  
N. N. Nagre ◽  
N. S. Umapathy ◽  
B. S. Pace ◽  
B. S. Basavarajappa
Keyword(s):  
Ethanol Exposure ◽  
Adult Mice
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