Alcohol Use Disorder and Non‐Fatal Suicide Attempt: Findings from a Swedish National Cohort Study

Addiction ◽  
2021 ◽  
Author(s):  
Alexis C. Edwards ◽  
Henrik Ohlsson ◽  
Eve Mościcki ◽  
Casey Crump ◽  
Jan Sundquist ◽  
...  
2021 ◽  
pp. 216770262110250
Author(s):  
Mallory E. Stephenson ◽  
Sara Larsson Lönn ◽  
Jessica E. Salvatore ◽  
Jan Sundquist ◽  
Kenneth S. Kendler ◽  
...  

The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently higher when the sibling’s AUD registration had occurred more recently. Our findings provide evidence for exposure to sibling AUD as an environmental risk factor for suicide attempt and suggest that clinical outreach may be warranted following a sibling’s diagnosis with AUD.


Addiction ◽  
2020 ◽  
Vol 115 (8) ◽  
pp. 1440-1449 ◽  
Author(s):  
Charlotte Holst ◽  
Janne S. Tolstrup ◽  
Holger J. Sørensen ◽  
Ulrik Becker

2021 ◽  
Vol 116 (1) ◽  
pp. S503-S503
Author(s):  
Patrick Twohig ◽  
Lauren Keim ◽  
Michelle Le ◽  
Nathalie Khoury ◽  
Wuttiporn Manatsathit ◽  
...  

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