Comment on ‘Higher mean platelet volume is associated with paediatric chronic spontaneous urticaria and with a more severe disease in the affected children’

2019 ◽  
Vol 61 (1) ◽  
pp. 79-80 ◽  
Author(s):  
Erkan Coban
Keyword(s):  
Mean Platelet Volume ◽  
Severe Disease ◽  
Chronic Spontaneous Urticaria ◽  
Platelet Volume

scholarly journals Diagnostic value of mean platelet volume in neonatal sepsis

2019 ◽  
Vol 59 (6) ◽  
pp. 289-93
Author(s):  
Kristopher May Pamudji ◽  
I Made Kardana
Keyword(s):  
Neonatal Sepsis ◽  
Predictive Value ◽  
Mean Platelet Volume ◽  
Severe Disease ◽  
Diagnostic Testing ◽  
Clinical Signs ◽  
Diagnostic Value ◽  
Platelet Volume ◽  
Good Potential ◽  
Sensitivity Specificity

Background Neonatal sepsis is a severe disease with potentially serious impacts if not treated early. However, the symptoms and clinical signs are not specific. Several studies have been conducted to find early infection markers for detection of neonatal sepsis, but without satisfactory results. Mean platelet volume (MPV) is a new marker of infection that has good potential for diagnosing neonatal sepsis. Objective To assess the diagnostic value of MPV in early detection of neonatal sepsis. Methods This retrospective study with diagnostic testing was done with data collected from medical records of neonates with neonatal sepsis who were admitted to the Neonatology Department in Sanglah Hospital, Denpasar from December 2018 to March 2019. Mean platelet volume cut-off point was determined using a receiver-operating characteristic (ROC) curve. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MPV in neonatal sepsis were determined using a 2x2 table. Results Of 82 subjects, 55 subjects were male (67%). Positive blood culture results were found in 25 subjects (30%). Mean platelet volume with a cut-off point of 7.44 fL had 80% sensitivity, 84.2% specificity, 69% PPV, and 90.6% NPV. Conclusion Mean platelet volume with a cut-off point of 7.44 fL can be used to diagnose neonatal sepsis with a sensitivity of 80% and specificity of 84.2%.

The role of mean platelet volume as an inflammatory marker in children with chronic spontaneous urticaria

2015 ◽  
Vol 43 (1) ◽  
pp. 10-13 ◽  
Author(s):  
A.Z. Akelma ◽  
E. Mete ◽  
M.N. Cizmeci ◽  
M.K. Kanburoglu ◽  
D.D. Malli ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Inflammatory Marker ◽  
Chronic Spontaneous Urticaria ◽  
Platelet Volume

scholarly journals Comparison of the Effects of Second Generation Antihistamines and Omalizumab Treatment on Neutrophil / Lymphocyte Ratio, Platelet / Lymphocyte Ratio and Mean Platelet Volume in Patients with Chronic Spontaneous Urticaria with Each Other and with the Control Group

2021 ◽  
Author(s):  
ZÜLKÜF ARSLAN ◽  
CEMAL BİLAÇ
Keyword(s):  
Platelet Count ◽  
Neutrophil Count ◽  
Mean Platelet Volume ◽  
Chronic Spontaneous Urticaria ◽  
Control Group ◽  
Platelet Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Pre Treatment

ABSTRACT Objective: Studies have shown that neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR) and mean platelet volume (MPV) can be used in CSU to evaluate inflammation marker and response to treatment. In our study, we aimed to compare the NLR, PLR and MPV values in the control group and pre-treatment patient groups, and to investigate the changes with antihistamine treatment and omalizumab treatment in the CSU patient group and control group. Materials and Methods: 146 patients who applied to Manisa Celal Bayar University Dermatology and Venereal Diseases outpatient clinic, with a diagnosis of chronic spontaneous urticaria, using antihistamine or omalizumab were included in the study. Results: The neutrophil and NLR values of the antihistamine and omalizumab treatment group with CSU diagnosis were found to be significantly higher than the pre-treatment control group, but there was no significant difference between each other. Platelet count was found higher and MPV value was found lower in omalizumab group compare to control group. In the omalizumab group, a significant decrease in neutrophil count and platelet count was measured at 3rd months. Conclusion: Neutrophil count, platelet count, NLR values were higher and MPV values were found to be low compared to the control group, these values can be used to measure disease activity. After the treatment, a significant decrease in neutrophil count and platelet count was detected in the omalizumab group. In addition to its anti-IgE effect, omalizumab can show its anti-inflammatory effect by reducing the neutrophil count and platelet count to be within the normal range.

scholarly journals Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

2020 ◽  
Author(s):  
Longhuan Zeng ◽  
Xueying Cai ◽  
Jiayi Chen ◽  
Guangyong Jin ◽  
Yongke Zheng
Keyword(s):  
Acute Pancreatitis ◽  
Mean Platelet Volume ◽  
Severe Disease ◽  
Fetal Mortality ◽  
Control Group ◽  
Platelet Volume ◽  
Pregnant Females ◽  
Significant Difference ◽  
Relevant Variables

Abstract Background: Hypertriglyceridemia-induced acute pancreatitis during pregnancy (HTG-APP) is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-APP remains unclear.Methods: In the retrospective study, we collected 45 patients with HTG-APP as the HTG-APP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared. Results: MPV were significantly higher in the HTG-APP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010). Logistic regression analyses revealed that MPV was significantly associated with SAP (odds ratio = 2.077, 95% confdence interval, 1.038-4.154; P = 0.039). Conclusions: These results may indicate an important role of mean platelet volume in evaluating the severity of HTG-APP.

scholarly journals Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

2019 ◽  
Author(s):  
Longhuan Zeng ◽  
Xueying Cai ◽  
Jiayi Chen ◽  
Guangyong Jin ◽  
Yongke Zheng
Keyword(s):  
Acute Pancreatitis ◽  
Mean Platelet Volume ◽  
Severe Disease ◽  
Fetal Mortality ◽  
Control Group ◽  
Platelet Volume ◽  
Pregnant Females ◽  
Significant Difference ◽  
Relevant Variables

Abstract Purpose Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) during pregnancy is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-AP during pregnancy remains unclear. This study aimed to assess the role of MPV and the potential relationship with disease severity in HTG-AP during pregnancy. Methods In the retrospective study, we collected 45 patients with HTG-AP during pregnancy as the HTG-AP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared. Results MPV levels were significantly higher in the HTG-AP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010). Conclusion These results may indicate an important role of MPV in evaluating the severity of HTG-AP during pregnancy.

scholarly journals Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Longhuan Zeng ◽  
Xueying Cai ◽  
Jiayi Chen ◽  
Guangyong Jin ◽  
Yongke Zheng
Keyword(s):  
Acute Pancreatitis ◽  
Mean Platelet Volume ◽  
Severe Disease ◽  
Fetal Mortality ◽  
Control Group ◽  
Platelet Volume ◽  
Pregnant Females ◽  
Significant Difference ◽  
Relevant Variables

Abstract Background Hypertriglyceridemia-induced acute pancreatitis during pregnancy (HTG-APP) is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-APP remains unclear. Methods In the retrospective study, we collected 45 patients with HTG-APP as the HTG-APP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared. Results MPV were significantly higher in the HTG-APP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010). Logistic regression analyses revealed that MPV was significantly associated with SAP (odds ratio = 2.077, 95% confdence interval, 1.038–4.154; P = 0.039). Conclusions These results may indicate an important role of mean platelet volume in evaluating the severity of HTG-APP.

scholarly journals Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

2020 ◽  
Author(s):  
Longhuan Zeng ◽  
Xueying Cai ◽  
Jiayi Chen ◽  
Guangyong Jin ◽  
Yongke Zheng
Keyword(s):  
Acute Pancreatitis ◽  
Mean Platelet Volume ◽  
Severe Disease ◽  
Fetal Mortality ◽  
Control Group ◽  
Platelet Volume ◽  
Pregnant Females ◽  
Significant Difference ◽  
Relevant Variables

Abstract Background: Hypertriglyceridemia-induced acute pancreatitis () during pregnancy (HTG-APP) is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-APP remains unclear. Methods: In the retrospective study, we collected 45 patients with HTG-APP as the HTG-APP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared. Results: MPV were significantly higher in the HTG-APP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. MPV levels were significantly higher There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010). Logistic regression analyses revealed that MPV was significantly associated with SAP ((odds ratio = 2.077, 95% confdence interval, 1.038-4.154; P = 0.039). - Conclusions: These results may indicate an important role of mean platelet volume in evaluating the severity of HTG-APP.

scholarly journals Mean Platelet Volume in Children with Chronic Spontaneous Urticaria

2017 ◽  
Vol 15 (2) ◽  
pp. 87-92 ◽  
Author(s):  
Şeyhan KUTLUĞ ◽  
Ayhan SÖĞÜT ◽  
Mehmet Halil ÇELİKSOY ◽  
Muhammet Şükrü PAKSU ◽  
Şükrü Nail GÜNER ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Chronic Spontaneous Urticaria ◽  
Platelet Volume

Klinische und labordiagnostische Parameter bei 21 Hunden mit primärer immunvermittelter Thrombozytopenie

2011 ◽  
Vol 39 (01) ◽  
pp. 17-24 ◽  
Author(s):  
H. J. Schuberth ◽  
R. Mischke ◽  
B. Dircks
Keyword(s):  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Klinische Relevanz

Zusammenfassung Gegenstand und Ziel: Charakterisierung von klinischen und labordiagnostischen Parametern sowie Therapie und Krankheitsverlauf bei Hunden mit einer angenommenen primären immunvermittelten Thrombozytopenie (pIMT) und Identifizierung möglicher Besonderheiten im Vergleich zu Hunden mit einer sekundären immunvermittelten Thrombozytopenie (sIMT). Material und Methoden: Retrospektive Auswertung von Patientendaten thrombozytopenischer Hunde, bei denen plättchengebundene Antikörper mittels Durchflusszytometrie nachgewiesen wurden. Ergebnisse: Dreizehn der 21 Hunde (62%) mit einer pIMT waren männlich. Das mittlere Alter bei Erstvorstellung betrug 6,6 Jahre (1,6–13,5 Jahre [Median; Minimum–Maximum]). Blutungen, hauptsächlich in Form von Haut- und Schleimhautblutungen, lagen bei 18 Hunden (86%) vor. Neunzehn Hunde (91%) wiesen eine Thrombozytenzahl unter 20000/μl auf. Bei allen Hunden mit einer pIMT ergab sich ein mittleres Thrombozytenvolumen (mean platelet volume, MPV) im oder unter dem Referenzbereich. In nahezu allen Fällen bestand eine gesteigerte Megakaryopoeseaktivität. Der Vergleich zweier Therapieregime (Prednisolon versus Prednisolon und Azathioprin) zeigte keinen signifikanten Unterschied bezüglich der Zeit bis zum Erreichen einer Thrombozytenzahl im Referenzbereich. Zwischen Patienten mit pIMT oder sIMT ließ sich im Hinblick auf Alter und Geschlecht kein signifikanter Unterschied feststellen. Bei Hunden mit einer pIMT waren Thrombozytenzahl und MPV signifikant niedriger und die Megakaryopoeseaktivität signifikant häufiger erhöht. Schlussfolgerung und klinische Relevanz: Bei Hunden, die plättchengebundene Antikörper und zusätzlich eine schwere Thrombozytopenie, ein niedriges MPV und eine gesteigerte Megakaryopoeseaktivität aufweisen, ist eine pIMT naheliegend.

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