Hormonal influence on HIV-1 transmission in the female genital tract: New insights from systems biology

2018 ◽  
Vol 80 (2) ◽  
pp. e13019
Author(s):  
Haley A. Dupont ◽  
Jeff Lam ◽  
Matthew W. Woods ◽  
Mohammed A. Zahoor ◽  
Charu Kaushic
Keyword(s):  
Systems Biology ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Hormonal Influence ◽  
Hiv 1 ◽  
Female Genital

scholarly journals Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach

2015 ◽  
Vol 89 (18) ◽  
pp. 9167-9177 ◽  
Author(s):  
S. A. Vishwanathan ◽  
A. Burgener ◽  
S. E. Bosinger ◽  
G. K. Tharp ◽  
P. C. Guenthner ◽  
...  
Keyword(s):  
Systems Biology ◽  
Menstrual Cycle ◽  
Hiv Infection ◽  
Genital Tract ◽  
Luteal Phase ◽  
Female Genital Tract ◽  
High Dose ◽  
Hormonal Changes ◽  
Hiv 1 ◽  
Female Genital

ABSTRACTOur earlier studies with pig-tailed macaques demonstrated various simian-human immunodeficiency virus (SHIV) susceptibilities during the menstrual cycle, likely caused by cyclic variations in immune responses in the female genital tract. There is concern that high-dose, long-lasting, injectable progestin-based contraception could mimic the high-progesterone luteal phase and predispose women to human immunodeficiency type 1 (HIV-1) acquisition and transmission. In this study, we adopted a systems biology approach employing proteomics (tandem mass spectrometry), transcriptomics (RNA microarray hybridization), and other specific protein assays (enzyme-linked immunosorbent assays and multiplex chemokine and cytokine measurements) to characterize the effects of hormonal changes on the expression of innate factors and secreted proteins in the macaque vagina. Several antiviral factors and pathways (including acute-phase response signaling and complement system) were overexpressed in the follicular phase. Conversely, during the luteal phase there were factors overexpressed (including moesins, syndecans, and integrins, among others) that could play direct or indirect roles in enhancing HIV-1 infection. Thus, our study showed that specific pathways and proteins or genes might work in tandem to regulate innate immunity, thus fostering further investigation and future design of approaches to help counter HIV-1 acquisition in the female genital tract.IMPORTANCEHIV infection in women is poorly understood. High levels of the hormone progesterone may make women more vulnerable to infection. This could be the case during the menstrual cycle, when using hormone-based birth control, or during pregnancy. The biological basis for increased HIV vulnerability is not known. We used an animal model with high risk for infection during periods of high progesterone. Genital secretions and tissues during the menstrual cycle were studied. Our goal was to identify biological factors upregulated at high progesterone levels, and we indeed show an upregulation of genes and proteins which enhance the ability of HIV to infect when progesterone is high. In contrast, during low-progesterone periods, we found more HIV inhibitory factors. This study contributes to our understanding of mechanisms that may regulate HIV infection in females under hormonal influences. Such knowledge is needed for the development of novel prevention strategies.

scholarly journals Selenium Deficiency Is Associated With Shedding of HIV-1–Infected Cells in the Female Genital Tract

2001 ◽  
Vol 26 (4) ◽  
pp. 360-364 ◽  
Author(s):  
Jared M. Baeten ◽  
Sara B. Mostad ◽  
Martin P. Hughes ◽  
Julie Overbaugh ◽  
Daniel D. Bankson ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Selenium Deficiency ◽  
Infected Cells ◽  
Hiv 1 ◽  
Female Genital

HIV-1 infection and the female genital tract

The Lancet ◽  
1996 ◽  
Vol 348 (9019) ◽  
pp. 59-60 ◽  
Author(s):  
Basil Donovan
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Hiv 1 ◽  
Female Genital

scholarly journals A Human Immunodeficiency Virus (HIV)–Inducing Factor from the Female Genital Tract Activates HIV‐1 Gene Expression through the κB Enhancer

1998 ◽  
Vol 178 (5) ◽  
pp. 1343-1351 ◽  
Author(s):  
Lena Al‐Harthi ◽  
Gregory T. Spear ◽  
Farhad B. Hashemi ◽  
Alan Landay ◽  
Beverly E. Sha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Immunodeficiency Virus ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Female Genital

scholarly journals Unraveling Molecular Signatures of Immunostimulatory Adjuvants in the Female Genital Tract through Systems Biology

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20448 ◽  
Author(s):  
Madelene Lindqvist ◽  
Intawat Nookaew ◽  
Ingrid Brinkenberg ◽  
Emma Samuelson ◽  
Karolina Thörn ◽  
...  
Keyword(s):  
Systems Biology ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Molecular Signatures ◽  
Female Genital

Differences in HIV-1 pol Sequences From Female Genital Tract and Blood During Antiretroviral Therapy

2003 ◽  
Vol 34 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Maria Pia De Pasquale ◽  
Andrew J. Leigh Brown ◽  
Susan Cu Uvin ◽  
Jessica Allega-Ingersoll ◽  
Angela M. Caliendo ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Hiv 1 ◽  
Female Genital
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