Effect of long-term testosterone propionate or human chorionic gonadotrophin administration on reproductive glands in adult male rabbits

Andrologia ◽  
2014 ◽  
Vol 47 (4) ◽  
pp. 455-463
Author(s):  
M. Abdel-Raouf ◽  
H. A. Hussein
Keyword(s):  
Adult Male ◽  
Testosterone Propionate ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin

Adrenal and gonadal function in hypothyroid adult male rats

1997 ◽  
Vol 152 (1) ◽  
pp. 147-154 ◽  
Author(s):  
A Tohei ◽  
M Akai ◽  
T Tomabechi ◽  
M Mamada ◽  
K Taya
Keyword(s):  
Adult Male ◽  
Functional Relationship ◽  
Plasma Concentrations ◽  
Gonadal Hormones ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Male Rats ◽  
Plasma Acth ◽  
Corticosterone Release ◽  
Acth Release

Abstract The functional relationship between thyroid, adrenal and gonadal hormones was investigated using adult male rats. Hypothyroidism was produced by the administration of 4-methyl-2-thiouracil (thiouracil) in the drinking water for 2 weeks. Plasma concentrations of TSH dramatically increased, whereas plasma concentrations of tri-iodothyronine and thyroxine decreased in thiouracil-treated rats as compared with euthyroid rats. Hypothyroidism increased basal levels of plasma ACTH and pituitary content of ACTH. The pituitary responsiveness to CRH for ACTH release markedly increased, whereas the adrenal responsiveness to ACTH for corticosterone release decreased. These results indicated that hypothyroidism causes adrenal dysfunction in adult male rats. Pituitary contents of LH and prolactin decreased in hypothyroid rats as compared with euthyroid rats. In addition, hypothyroidism lowered pituitary LH responsiveness to LHRH. Testicular responsiveness to human chorionic gonadotrophin for testosterone release, however, was not different between euthyroid and hypothyroid animals. These results indicated that hypothyroidism causes adrenal dysfunction and results in hypersecretion of ACTH from the pituitary gland. Adrenal dysfunction may contribute to the inhibition of LHRH secretion from the hypothalamus, possibly mediated by excess CRH. Journal of Endocrinology (1997) 152, 147–154

Induction of selective release of FSH in castrated male rats bearing an ovarian transplant by the administration of human chorionic gonadotrophin

1985 ◽  
Vol 106 (1) ◽  
pp. 31-NP ◽  
Author(s):  
G. Watanabe ◽  
K. Taya ◽  
S. Sasamoto
Keyword(s):  
Adult Male ◽  
Sex Differentiation ◽  
Plasma Concentrations ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Male Rats ◽  
Corpora Lutea ◽  
Female Rat ◽  
Nacl Solution ◽  
Abrupt Decrease

ABSTRACT The present study was undertaken to determine whether hypothalamic differentiation is involved in the selective release of FSH during the periovulatory period using adult male rats castrated and implanted with an ovary. Adult male rats (70–90 days old) were castrated and an ovary obtained from a prepubertal female rat (26 days old) was immediately grafted subcutaneously. Four weeks later, human chorionic gonadotrophin (hCG, 10 i.u.) was injected i.v. into the experimentally manipulated rats to induce ovulatory changes in the grafted ovaries. Another group of similarly prepared rats was injected with 0·9% (w/v) NaCl solution as controls. After injection of hCG, plasma concentrations of FSH increased significantly by 6 h, reached peak values at 12 h and declined to control levels at 36 h. On the other hand, plasma concentrations of LH were reduced by 6 h and decreased further during the next 36 h. An abrupt fall in plasma concentrations of oestradiol-17β occurred within 3 h of the administration of hCG. Histological examination revealed that ovulatory changes and luteinization of follicles were induced in grafted ovaries by 18 h after the injection of hCG. Thirty-six hours after treatment with hCG, a set of newly formed corpora lutea was observed in grafted ovaries and plasma concentrations of progesterone were raised. Treatment with oestradiol-17β did not inhibit the selective release of FSH after the administration of hCG, suggesting that the abrupt decrease in secretion of oestradiol-17β from the grafted ovary is not involved in the occurrence of the FSH surge. These results indicate that a selective release of FSH can be induced in castrated male rats bearing an ovarian transplant probably due to decreased secretion of inhibin by the luteinized follicles in the grafted ovaries. Sex differentiation of the hypothalamus is not, therefore, involved in the selective surge of FSH. J. Endocr. (1985) 106, 31–36

The functional regeneration of syncytiotrophoblast in cultured explants of term placenta

2001 ◽  
Vol 280 (4) ◽  
pp. R1116-R1122 ◽  
Author(s):  
C. M. Simán ◽  
C. P. Sibley ◽  
C. J. P. Jones ◽  
M. A. Turner ◽  
S. L. Greenwood
Keyword(s):  
Lactate Dehydrogenase ◽  
Culture System ◽  
Culture Medium ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Ang Ii ◽  
Placental Function ◽  
Culture Time ◽  
Functional Regeneration

We have investigated the functional characteristics of term human placental villous explants kept in long-term (7–11 days) culture. Fragments of placental villous tissue (∼5–10 mg wet wt) were cultured in supplemented CMRL-1066 culture medium for up to 11 days. After the first day of culture, the syncytiotrophoblast appeared vacuolated and eventually degenerated. However, a new syncytiotrophoblast developed by day 4, being indistinguishable from that of a fresh placenta by 11 days. Release of human chorionic gonadotrophin increased and activity of lactate dehydrogenase in culture medium decreased with culture time. Transport variables were measured over the first 7 days of culture. Basal86Rb efflux was reduced with time in culture and was inhibited by Ba2+, suggesting the efflux was mediated by K+ channels. At all stages of culture, 86Rb efflux was stimulated by ATP, hyposmotic medium, and ANG II. A complex pattern of efflux changes with culture time and type of stimulator was observed, suggesting that several compartments of the tissue contributed to stimulated efflux. This culture system provides opportunities for studies of chronic regulation of placental function.

THE USE OF NON-CASTRATE PARABIOTIC RATS FOR THE EVALUATION OF PLASMA GONADOTROPHINS

1966 ◽  
Vol 51 (2) ◽  
pp. 269-280 ◽  
Author(s):  
Donald C. Johnson
Keyword(s):  
Testosterone Propionate ◽  
Follicular Development ◽  
Compensatory Hypertrophy ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Female Rats ◽  
Intact Male ◽  
Female Partners ◽  
Bilateral Cryptorchidism ◽  
Accessory Sex Organs

ABSTRACT The gonads and accessory sex organs of hypophysectomized male or female rats were used to evaluate the gonadotrophin content of the plasma from a non-castrate parabiotic partner. Ovarian follicular development and the human chorionic gonadotrophin augmentation reaction indicated the presence of FSH in the plasma of immature males. LH was apparent by androgen production from testes in hypophysectomized male partners. The amount of LH was reduced by 2 mg progesterone or 20 μg testosterone propionate (TP) and increased by administration of hypothalamic extract daily to the intact male. Bilateral cryptorchidism also quickly elevated the plasma LH level. FSH output, as measured by follicular development in females, was not significantly affected by 50 μg TP or 2 μg oestradiol daily for 10 days. Females had little gonadotrophin in their plasma since hypophysectomized female partners showed only slight ovarian and no uterine stimulation. The increased gonadotrophins associated with unilateral compensatory hypertrophy, however, was quickly manifested in follicular hypertrophy and abundant oestrogen production in the hypophysectomized partner.

Long-term outcome of patients with persistent low-level elevation of human chorionic gonadotrophin

2016 ◽  
Vol 42 (6) ◽  
pp. 694-700 ◽  
Author(s):  
Xue-qian Qian ◽  
Li-li Chen ◽  
Bao-hua Li ◽  
Xiao-dong Cheng ◽  
Xiao-yun Wan
Keyword(s):  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Low Level ◽  
Level Elevation

OVULATION INDUCED BY PREGNANT MARE SERUM GONADOTROPHIN IN THE IMMATURE RAT TREATED NEONATALLY WITH A LOW OR A HIGH DOSE OF ANDROGEN

1972 ◽  
Vol 55 (3) ◽  
pp. 533-541 ◽  
Author(s):  
J. Th. J. UILENBROEK ◽  
J. J. van der WERFF ten BOSCH
Keyword(s):  
Testosterone Propionate ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Female Rats ◽  
High Dose ◽  
Immature Female ◽  
Immature Rat ◽  
Progesterone Treatment ◽  
Combined Administration ◽  
Pregnant Mare Serum Gonadotrophin

SUMMARY Ovulation-inducing effects of pregnant mare serum gonadotrophin (PMSG) were studied in immature female rats treated on day 5 (day 1 = day of birth) with oil or with 5 or 1250 μg testosterone propionate (TP). The response of rats treated with 1250 μg TP was negligible regardless of the age of the animals and of the dose of PMSG. The response of rats treated with 5 μg TP to PMSG alone was low (36% of rats, with 2·6 ova/ovulating rat), but could be improved by progesterone administration 2 days after PMSG injection (91% of rats, with 14·5 ova/ovulating rat). At every age and dose of PMSG tested the response of animals treated with 5 μg TP to combined PMSG and progesterone treatment was less than that of control animals. It is concluded that neonatal TP treatment diminishes the release of endogenous ovulating hormone subsequent to PMSG injection. This effect is dependent on the dose of TP used, but already demonstrable in animals treated with 5 μg TP on day 5, which would have been cyclic and fertile after puberty. Only for the animals treated with 1250 μg TP could a decreased sensitivity of the ovaries to combined administration of PMSG and human chorionic gonadotrophin be demonstrated.

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