Dysregulation of mitochondrial sirtuin genes is associated with human male infertility

Andrologia ◽  
2021 ◽  
Author(s):  
Jaafar Haris Bello ◽  
Muhammad Jadoon Khan ◽  
Saira Amir ◽  
Hoor Gulalai Kakakhel ◽  
Faheem Tahir ◽  
...  
Keyword(s):  
Male Infertility ◽  
Human Male

scholarly journals Molecular Genetic of Human Male Infertility: From Genes to New Therapeutic Perspectives

2004 ◽  
Vol 10 (5) ◽  
pp. 471-500 ◽  
Author(s):  
Peter Vogt
Keyword(s):  
Male Infertility ◽  
Molecular Genetic ◽  
Human Male

Germline Telomere Attrition is Associated with Human Male Infertility

2016 ◽  
Vol 5 (2) ◽  
pp. 37-44
Author(s):  
S. Pathak ◽  
◽  
A.S. Multani ◽  
S.H. Sohn ◽  
N.J. Gupta ◽  
...  
Keyword(s):  
Male Infertility ◽  
Telomere Attrition ◽  
Human Male

scholarly journals Haploid male germ cells—the Grand Central Station of protein transport

2020 ◽  
Vol 26 (4) ◽  
pp. 474-500 ◽  
Author(s):  
Christiane Pleuger ◽  
Mari S Lehti ◽  
Jessica EM Dunleavy ◽  
Daniela Fietz ◽  
Moira K O’Bryan
Keyword(s):  
Male Infertility ◽  
Protein Transport ◽  
Model System ◽  
Sperm Head ◽  
Vesicle Transport ◽  
Future Research ◽  
Significant Percentage ◽  
Human Male ◽  
Abnormal Sperm ◽  
Haploid Male

Abstract BACKGROUND The precise movement of proteins and vesicles is an essential ability for all eukaryotic cells. Nowhere is this more evident than during the remarkable transformation that occurs in spermiogenesis—the transformation of haploid round spermatids into sperm. These transformations are critically dependent upon both the microtubule and the actin cytoskeleton, and defects in these processes are thought to underpin a significant percentage of human male infertility. OBJECTIVE AND RATIONALE This review is aimed at summarising and synthesising the current state of knowledge around protein/vesicle transport during haploid male germ cell development and identifying knowledge gaps and challenges for future research. To achieve this, we summarise the key discoveries related to protein transport using the mouse as a model system. Where relevant, we anchored these insights to knowledge in the field of human spermiogenesis and the causality of human male infertility. SEARCH METHODS Relevant studies published in English were identified using PubMed using a range of search terms related to the core focus of the review—protein/vesicle transport, intra-flagellar transport, intra-manchette transport, Golgi, acrosome, manchette, axoneme, outer dense fibres and fibrous sheath. Searches were not restricted to a particular time frame or species although the emphasis within the review is on mammalian spermiogenesis. OUTCOMES Spermiogenesis is the final phase of sperm development. It results in the transformation of a round cell into a highly polarised sperm with the capacity for fertility. It is critically dependent on the cytoskeleton and its ability to transport protein complexes and vesicles over long distances and often between distinct cytoplasmic compartments. The development of the acrosome covering the sperm head, the sperm tail within the ciliary lobe, the manchette and its role in sperm head shaping and protein transport into the tail, and the assembly of mitochondria into the mid-piece of sperm, may all be viewed as a series of overlapping and interconnected train tracks. Defects in this redistribution network lead to male infertility characterised by abnormal sperm morphology (teratozoospermia) and/or abnormal sperm motility (asthenozoospermia) and are likely to be causal of, or contribute to, a significant percentage of human male infertility. WIDER IMPLICATIONS A greater understanding of the mechanisms of protein transport in spermiogenesis offers the potential to precisely diagnose cases of male infertility and to forecast implications for children conceived using gametes containing these mutations. The manipulation of these processes will offer opportunities for male-based contraceptive development. Further, as increasingly evidenced in the literature, we believe that the continuous and spatiotemporally restrained nature of spermiogenesis provides an outstanding model system to identify, and de-code, cytoskeletal elements and transport mechanisms of relevance to multiple tissues.

DECREASED AMOUNTS OF DESOXYRIBOSE NUCLEIC ACID (DNA) IN MALE GERM CELLS AS A POSSIBLE CAUSE OF HUMAN MALE INFERTILITY

1956 ◽  
Vol 6 (2) ◽  
pp. 272-278
Author(s):  
Cecilie Leuchtenberger ◽  
D.R. Weir ◽  
F. Schrader ◽  
R. Leuchtenberger
Keyword(s):  
Nucleic Acid ◽  
Male Infertility ◽  
Germ Cells ◽  
Male Germ Cells ◽  
Human Male ◽  
Possible Cause

RNA-binding proteins and human male infertility

1997 ◽  
Vol 13 (3) ◽  
pp. 87-89 ◽  
Author(s):  
H Cooke
Keyword(s):  
Male Infertility ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Human Male

The controversial efficacy of vitamin E for human male infertility

Contraception ◽  
2002 ◽  
Vol 65 (4) ◽  
pp. 313-315 ◽  
Author(s):  
Paola Bolle ◽  
Maria Grazia Evandri ◽  
Luciano Saso
Keyword(s):  
Vitamin E ◽  
Male Infertility ◽  
Human Male

Creation of knock out and knock in mice by CRISPR/Cas9 to validate candidate genes for human male infertility, interest, difficulties and feasibility

2018 ◽  
Vol 468 ◽  
pp. 70-80 ◽  
Author(s):  
Zine-Eddine Kherraf ◽  
Beatrice Conne ◽  
Amir Amiri-Yekta ◽  
Marie Christou Kent ◽  
Charles Coutton ◽  
...  
Keyword(s):  
Male Infertility ◽  
Candidate Genes ◽  
Knock Out ◽  
Human Male

scholarly journals Role of isoprostanes in human male infertility

2020 ◽  
Vol 66 (5) ◽  
pp. 291-299
Author(s):  
Cinzia Signorini ◽  
Elena Moretti ◽  
Giulia Collodel
Keyword(s):  
Male Infertility ◽  
Human Male

Folinic acid in the treatment of human male infertility

1993 ◽  
Vol 60 (4) ◽  
pp. 698-701 ◽  
Author(s):  
Giorgio Bentivoglio ◽  
Francesco Melica ◽  
Paolo Cristoforoni
Keyword(s):  
Male Infertility ◽  
Folinic Acid ◽  
Human Male

Specific Expression of VCY2 in Human Male Germ Cells and Its Involvement in the Pathogenesis of Male Infertility

2003 ◽  
Vol 69 (3) ◽  
pp. 746-751 ◽  
Author(s):  
J.Y.M. Tse ◽  
E.Y.M. Wong ◽  
A.N.Y. Cheung ◽  
W.S. O ◽  
P.C. Tam ◽  
...  
Keyword(s):  
Male Infertility ◽  
Germ Cells ◽  
Specific Expression ◽  
Male Germ Cells ◽  
Human Male
Sign in / Sign up

Export Citation Format

Share Document