scholarly journals Safety Of Electro‐Oxidation For Urea Removal In A Wearable Artificial Kidney Is Compromised By Formation Of Glucose Degradation Products

2021 ◽  
Author(s):  
Maaike K. van Gelder ◽  
Jeroen C. Vollenbroek ◽  
Babette H. Lentferink ◽  
Diënty H.M. Hazenbrink ◽  
Paul J. Besseling ◽  
...  
Keyword(s):  
Degradation Products ◽  
Artificial Kidney ◽  
Glucose Degradation Products ◽  
Electro Oxidation ◽  
Wearable Artificial Kidney

scholarly journals Will Nephrologists Use a Wearable Artificial Kidney?

2009 ◽  
Vol 4 (9) ◽  
pp. 1401-1402 ◽  
Author(s):  
Eli A. Friedman
Keyword(s):  
Artificial Kidney ◽  
Wearable Artificial Kidney

Mathematical Modeling of Sorption in a Wearable Artificial Kidney with Dialysate Regeneration

2017 ◽  
Vol 50 (5) ◽  
pp. 318-320
Author(s):  
N. A. Bazaev ◽  
I. O. Bizyukov ◽  
E. V. Streltsov
Keyword(s):  
Mathematical Modeling ◽  
Artificial Kidney ◽  
Wearable Artificial Kidney

The Wearable Artificial Kidney, Why and How: From Holy Grail to Reality

Dialysis ◽  
2012 ◽  
pp. 821-827
Author(s):  
Victor Gura ◽  
Andrew Davenport ◽  
Claudio Ronco
Keyword(s):  
Artificial Kidney ◽  
Holy Grail ◽  
Wearable Artificial Kidney

Glucose Degradation Products in Dialysis

Dialysis ◽  
2012 ◽  
pp. 715-722
Author(s):  
Per T.T. Kjellstrand ◽  
A.P. Wieslander
Keyword(s):  
Degradation Products ◽  
Glucose Degradation Products

Continuous Ultrafiltration and Dialysis with a Wearable Artificial Kidney

2009 ◽  
pp. 1426-1431
Author(s):  
Victor Gura ◽  
Claudio Ronco
Keyword(s):  
Artificial Kidney ◽  
Wearable Artificial Kidney

Glucose Degradation Products and Peritoneal Membrane Function

2001 ◽  
Vol 21 (2) ◽  
pp. 201-207 ◽  
Author(s):  
Janusz Witowski ◽  
Thorsten O. Bender ◽  
Gerhard M. Gahl ◽  
Ulrich Frei ◽  
Achim Jörres
Keyword(s):  
Peritoneal Dialysis ◽  
Cell Viability ◽  
Degradation Products ◽  
Membrane Function ◽  
Peritoneal Mesothelial Cells ◽  
Glucose Degradation Products ◽  
And Function ◽  
The Impact ◽  
Dialysis Fluids

Background The bioincompatibility of peritoneal dialysis fluids (PDF) in current use has been partially attributed to the presence of glucose degradation products (GDPs), which are generated during heat sterilization of PDF. Several of the GDPs have been identified and we have recently demonstrated that these GDPs per se may impair the viability and function of human peritoneal mesothelial cells (HPMC) in vitro. It is also possible that GDP-related toxicity is further exacerbated by the milieu of PDF. We review the current literature on GDP and present the results of experiments comparing the impact of heat- and filter-sterilized PDF on the viability and function of HPMC. Methods Peritoneal dialysis fluids with low (1.5%) and high (4.25%) glucose concentrations were laboratory prepared according to the standard formula and sterilized either by heat (H-PDF; 121°C, 0.2 MPa, 20 minutes) or filtration (F-PDF; 0.2 μ). The buildup of GDP was confirmed by UV absorbance at 284 nm. Confluent HPMC monolayers were exposed to these solutions mixed 1:1 with standard M199 culture medium. After 24 hours, cell viability was assessed with the MTT assay, and interleukin-1β–stimulated monocyte chemotactic protein-1 (MCP-1) release with specific immunoassay. Results Exposure of HPMC to H-PDF resulted in a significant decrease in cell viability, with solutions containing 4.25% glucose being more toxic than 1.5% glucose-based PDF (27.4% ± 3.4% and 53.4% ± 11.0% of control values, respectively). In contrast, viability of HPMC exposed to F-PDF was not different from that of control cells. Moreover, treatment with H-PDF impaired the release of MCP-1 from HPMC to a significantly greater degree compared to F-PDF (17.4% and 24.9% difference for low and high glucose PDF, respectively). Conclusions Exposure of HPMC to H-PDF significantly impairs cell viability and the capacity for generating MCP-1 compared to F-PDF. This effect is likely to be mediated by GDPs present in H-PDF but not in F-PDF.

Peritoneal Dialysis Solutions Low in Glucose Degradation Products—evidence for Clinical Benefits

2008 ◽  
Vol 28 (3_suppl) ◽  
pp. 123-127
Author(s):  
Tadashi Tomo
Keyword(s):  
Peritoneal Dialysis ◽  
Vascular Function ◽  
Degradation Products ◽  
Peritoneal Mesothelial Cells ◽  
Advanced Glycosylation End Products ◽  
Glucose Degradation Products ◽  
Peritoneal Dialysis Fluid ◽  
Clinical Benefits ◽  
Human Peritoneal Mesothelial Cells ◽  
Peritoneal Function

In Japan, two types of new peritoneal dialysis fluid (PDF) are ordinarily used: two-chambered PDF, and icodextrin PDF. Two-chambered PDF has several biocompatible characteristics, one being low glucose degradation products (GDPs). Of the several GDPs in PDF, 3,4-dideoxyglucosone-3-ene (3,4-DGE) is thought to be strongly associated with the cytotoxicity of standard PDF. Using a PDF low in GDPs may reduce exposure of the peritoneum to 3,4-DGE, helping to preserve peritoneal function in PD patients. Additionally, use of a PDF low in GDPs may reduce plasma levels of advanced glycosylation end-products in PD patients, a change that may help to preserve vascular function in PD patients. Peritoneal rest for 24 hours after exposure to a PDF with low GDPs improves the activity of human peritoneal mesothelial cells. As compared with the use of standard PDF, the use of low-GDP PDF in combination therapy (peritoneal dialysis plus hemodialysis) may more effectively preserve peritoneal function. The new PDF low in GDPs has bio-compatible characteristics relative to peritoneum and system that may help to preserve peritoneal function or reduce complications such as atherosclerosis or dialysis-related amyloidosis in dialysis patients.

Evidence for Less Irritation to the Peritoneal Membrane in Rats Dialyzed with Solutions Low in Glucose Degradation Products

2004 ◽  
Vol 24 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Katarzyna Wieczorowska–Tobis ◽  
Renata Brelinska ◽  
Janusz Witowski ◽  
Jutta Passlick–Deetjen ◽  
Thomas P. Schaub ◽  
...  
Keyword(s):  
Structural Integrity ◽  
Degradation Products ◽  
Low Ph ◽  
Vascular Density ◽  
Peritoneal Membrane ◽  
Single Chamber ◽  
Neutral Ph ◽  
Glucose Degradation Products ◽  
Chronic Infusion ◽  
New Generation

Background Acidic pH and the presence of glucose degradation products (GDP) are believed to compromise the biocompatibility of peritoneal dialysis fluids (PDF). The present study examines the effects of long-term exposure to GDP and low pH by comparing conventional PDF and a new, neutral pH, low GDP solution. Methods All experiments were performed using a chronic infusion model of dialysis in nonuremic rats. The animals were treated for 6 weeks with 2 daily injections of 4.25% glucose-containing PDF. The following PDF were tested: CAPD3 (single-chamber bag, low pH, high GDP), CAPD3 pH 7.4 (single-chamber bag, neutral pH, high GDP), CAPD3-Balance (double-chamber bag, neutral pH, low GDP). All test solutions were obtained from Fresenius Medical Care, Bad Homburg, Germany. Results After 6 weeks of exposure, peritoneal permeability to water, urea, creatinine, glucose, and sodium, assessed by peritoneal equilibration test, was similar in all groups. However, compared to other PDF, dialysis with CAPD3-Balance was associated with reduced concentrations of protein and hyaluronan in the dialysate, decreased peritoneal eosinophilia, and reduced dialysate levels of chemokines CCL2/MCP-1 and CCL5/RANTES. Morphologic changes in the peritoneal membrane of CAPD3-Balance-treated animals were much less pronounced and included reduced vascular density, preservation of the mesothelial monolayer and intercellular junction, and no reduplication of the submesothelial basement membrane. Conclusions A new generation of PDF with physiologic pH and low GDP level produce less irritation to the peritoneal membrane and better preserve its structural integrity. This effect seems to be related predominantly to minimized GDP concentrations.

Sign in / Sign up

Export Citation Format

Share Document