Association between chronic viral hepatitis and metabolic syndrome in southern Taiwan: a large population-based study

This study sought to determine whether chronic hepatitis B or C would modify the association between insulin analogues and hepatocellular carcinoma (HCC) risks. We conducted a nationwide nested case-control study for HCC cases and matched controls from 2003 to 2013 among newly diagnosed type 2 diabetes patients on any antidiabetic agents in Taiwan before and after exclusion of chronic viral hepatitis, respectively. A total of 5832 and 1237 HCC cases were identified before and after exclusion of chronic viral hepatitis, respectively. Incident HCC risks were positively associated with any use of premixed insulin analogues (adjusted odds ratio (OR), 1.27; 95% CI 1.04 to 1.55) among total participants, especially among current users (adjusted OR, 1.45; 95% CI 1.12 to 1.89). However, the association between HCC occurrence and premixed insulin analogues diminished among participants without chronic viral hepatitis (adjusted OR, 1.35; 95% CI 0.92 to 1.98). We also observed a significant multiplicative interaction between chronic viral hepatitis and premixed insulin analogues on HCC risks (P = 0.010). Conclusions: Chronic viral hepatitis signifies the role of premixed insulin analogues in HCC oncogenesis. We recommend a closer liver surveillance among patients prescribed premixed insulin analogues with concomitant chronic viral hepatitis.

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Mo1482 - Awareness Rate of Chronic Viral Hepatitis in the United States: A Population-Based Study

Gastroenterology ◽

10.1016/s0016-5085(18)32543-5 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-728-S-729 ◽

Cited By ~ 1

Author(s):

Hyunseok Kim ◽

Ju Dong Yang

Keyword(s):

United States ◽

Viral Hepatitis ◽

The United States ◽

Population Based ◽

Chronic Viral Hepatitis ◽

Population Based Study

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Exploring the association between thyroid- stimulating hormone and metabolic syndrome: A large population-based study

PLoS ONE ◽

10.1371/journal.pone.0199209 ◽

2018 ◽

Vol 13 (6) ◽

pp. e0199209 ◽

Cited By ~ 4

Author(s):

Yi-Chao Zhou ◽

Wen-Hui Fang ◽

Tung-Wei Kao ◽

Chung-Ching Wang ◽

Yaw-Wen Chang ◽

...

Keyword(s):

Metabolic Syndrome ◽

Large Population ◽

Population Based ◽

Thyroid Stimulating Hormone ◽

Population Based Study ◽

Stimulating Hormone

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The Prevalence of Viral Hepatitis C in Latvia: A Population-Based Study

Medicina ◽

10.3390/medicina47100076 ◽

2011 ◽

Vol 47 (10) ◽

pp. 76 ◽

Cited By ~ 6

Author(s):

Ieva Tolmane ◽

Baiba Rozentale ◽

Jazeps Keiss ◽

Frida Arsa ◽

Girts Brigis ◽

...

Keyword(s):

Hepatitis C ◽

Viral Hepatitis ◽

Primary Care Physicians ◽

Screening Method ◽

Population Based ◽

Chronic Viral Hepatitis ◽

Confirmatory Test ◽

Hcv Rna ◽

Population Based Study ◽

Viral Hepatitis C

Background and Objective. Chronic viral hepatitis C (VHC) is one of the most discussed infectious diseases worldwide. The number of infected persons worldwide is approximately 170 million, and in Europe, it exceeds 9 million. The aim of this study was to determine the prevalence of antibodies to hepatitis C virus (anti- HCV prevalence) and prevalence of HCV viremia (HCV-RNA prevalence) in Latvia. Material and Methods. A multistage randomized selection was used. A total of 42 primary care physicians (PCPs) were randomly selected from the register of PCPs from different regions of Latvia. From each PCP register, 60 subjects were selected (1651 individuals in total) and invited for the anti-HCV test with a screening method (ELISA). In case of positive results, antibodies were confirmed by the Western blot test, and all these subjects were tested for HCV-RNA by polymerase chain reaction. Results. Of the 1459 subjects tested, 57 were positive for anti-HCV (3.9%; 95% CI 3% to 5%); 35 of them were positive for anti-HCV with a confirmatory test (2.4%; 95% CI, 1.7% to 3.3%): 19 men and 16 women (3.8% and 1.7%, respectively; P=0.011). The results of HCV RNA test were positive in 25 subjects (1.7%; 95% CI, 1.2% to 2.5%): 15 men and 10 women (3% and 1% respectively, P=0.019). Conclusions. The prevalence of anti-HCV and HCV-RNA in Latvia was found to be 2.4% and 1.7%, respectively. The prevalence of anti-HCV and HCV-RNA was higher in men than women.

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Faculty Opinions recommendation of The early prediction of mortality in acute pancreatitis: a large population-based study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1115429.623303 ◽

2009 ◽

Author(s):

Enrique Dominguez-Munoz ◽

Julio Iglesias-Garcia

Keyword(s):

Acute Pancreatitis ◽

Large Population ◽

Population Based ◽

Early Prediction ◽

Population Based Study ◽

Prediction Of Mortality

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Dietary and lifestyle inflammatory scores are associated with increased risk of metabolic syndrome in Iranian adults

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-021-00648-1 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Hossein Farhadnejad ◽

Karim Parastouei ◽

Hosein Rostami ◽

Parvin Mirmiran ◽

Fereidoun Azizi

Keyword(s):

Metabolic Syndrome ◽

Positive Association ◽

Population Based ◽

Population Based Study ◽

Logistic Regression Models ◽

Increased Risk ◽

Confounding Variables ◽

Adjusted Model ◽

Diet And Lifestyle

Abstract Background In the current study, we aimed to investigate the association of dietary inflammation scores (DIS) and lifestyle inflammation scores (LIS) with the risk of metabolic syndrome (MetS) in a prospective population-based study. Methods A total of 1625 participants without MetS were recruited from among participants of the Tehran Lipid and Glucose Study(2006–2008) and followed a mean of 6.1 years. Dietary data of subjects were collected using a food frequency questionnaire at baseline to determine LIS and DIS. Multivariable logistic regression models, were used to calculate the odds ratio (ORs) and 95 % confidence interval (CI) of MetS across tertiles of DIS and LIS. Results Mean ± SD age of individuals (45.8 % men) was 37.5 ± 13.4 years. Median (25–75 interquartile range) DIS and LIS for all participants was 0.80 (− 2.94, 3.64) and 0.48 (− 0.18, − 0.89), respectively. During the study follow-up, 291 (17.9 %) new cases of MetS were identified. Based on the age and sex-adjusted model, a positive association was found between LIS (OR = 7.56; 95% CI 5.10–11.22, P for trend < 0.001) and risk of MetS, however, the association of DIS and risk of MetS development was not statistically significant (OR = 1.30;95% CI 0.93–1.80, P for trend = 0.127). In the multivariable model, after adjustment for confounding variables, including age, sex, body mass index, physical activity, smoking, and energy intake, the risk of MetS is increased across tertiles of DIS (OR = 1.59; 95% CI 1.09–2.33, P for trend = 0.015) and LIS(OR = 8.38; 95% CI 5.51–12.7, P for trend < 0.001). Conclusions The findings of the current study showed that greater adherence to LIS and DIS, determined to indicate the inflammatory potential of diet and lifestyle, are associated with increased the risk of MetS.

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