scholarly journals The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients: a randomized controlled trial

2021 ◽  
Author(s):  
Hua Yang ◽  
Qian Zhao ◽  
Hai‐yan Chen ◽  
Wen Liu ◽  
Tong Ding ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Elderly Patients ◽  
Gastrointestinal Endoscopy ◽  
Controlled Trial ◽  
Effective Concentration ◽  
Randomized Controlled ◽  
Median Effective Concentration ◽  
Different Doses

scholarly journals The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients：a randomized controlled trial

2021 ◽  
Author(s):  
Hua Yang ◽  
Qian Zhao ◽  
Hai-yan Chen ◽  
Wen Liu ◽  
Tong Ding ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Gastrointestinal Endoscopy ◽  
Controlled Trial ◽  
Effective Concentration ◽  
Saline Control ◽  
Control Group ◽  
Aspartate Receptor ◽  
Initial Plasma ◽  
Median Effective Concentration ◽  
Different Doses

Abstract Background: Propofol may result in hypotension, bradycardia, and loss of protective reflexes, especially in elderly patients, while esketamine, a N-methyl-D-aspartate receptor antagonists, has analgesic, anaesthetic and sympathomimetic properties and is known to cause less cardiorespiratory depression. We hypothesized that esketamine may reduce the median effective concentration (EC50) of propofol and cause more stable haemodynamic responses during gastrointestinal endoscopy in elderly patients. Methods: Ninety elderly patients, aged 65-89 years, undergoing gastrointestinal endoscopy were randomly assigned into three groups: SK0.25 group (0.25 mg/kg esketamine), SK0.5 group (0.5 mg/kg esketamine) and saline control group. Anaesthesia was achieved by target-controlled infusion of propofol with an initial plasma concentration of 2.5 μg/ml with different bolus doses of esketamine during gastrointestinal endoscopy. The EC50 of propofol for gastrointestinal endoscopy was determined by using an up-and-down method of Dixon with an adjacent concentration gradient at 0.5μg/mL to prohibit purposeful movements. Cardiovascular parameters were also measured and recorded. Results: Propofol EC50 and its 95% confidence interval for gastrointestinal endoscopy in elderly patients were 1.71 (1.15-2.27) μg/mL in SK0.5 group, 2.45 (1.85-3.05) μg/mL in SK0.25 group and 3.69 (2.59-4.78) μg/mL in control group respectively (P < 0.05). The average percent change to baseline mean arterial pressure (MBP) was -19.7 (7.55), -15.2 (7.14) and -10.1 (6.73) with P＜0.001, in the control group, the SK0.25 group and the SK0.5 group, respectively. Conclusions: Combination medication of propofol with esketamine reduced the propofol EC50 during gastrointestinal endoscopy in elderly patients and caused more stable haemodynamic responses compared with single administration of propofol.

scholarly journals Different doses of steroid injection in elderly patients with carpal tunnel syndrome: a triple-blind, randomized, controlled trial

2018 ◽  
Vol Volume 13 ◽  
pp. 117-124 ◽  
Author(s):  
Reza Salman Roghani ◽  
Mohammad Taghi Holisaz ◽  
Masoud Tarkashvand ◽  
Ahmad Delbari ◽  
Faeze Gohari ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Carpal Tunnel Syndrome ◽  
Elderly Patients ◽  
Carpal Tunnel ◽  
Steroid Injection ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Tunnel Syndrome ◽  
Different Doses

scholarly journals Safety and efficacy of adding different doses of neostigmine as an adjuvant in peribulbar block for cataract surgery: A randomized controlled trial

2021 ◽  
Vol 37 (1) ◽  
pp. 349-355
Author(s):  
Iman S. Aboul Fetouh ◽  
Norhan A. Sherif ◽  
Noha A. Osama ◽  
Mayada K. Mohamad
Keyword(s):  
Randomized Controlled Trial ◽  
Cataract Surgery ◽  
Controlled Trial ◽  
Safety And Efficacy ◽  
Randomized Controlled ◽  
Peribulbar Block ◽  
Different Doses

Moxibustion with different doses for primary dysmenorrhea of cold congelation and blood stasis type: A randomized controlled trial

2021 ◽  
Author(s):  
Wen-ying SHI ◽  
Rong LUO ◽  
Xiao-juan LIU ◽  
Ying-han LIU ◽  
Zheng-liang CAO ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Blood Stasis ◽  
Type A ◽  
Primary Dysmenorrhea ◽  
Randomized Controlled ◽  
Different Doses
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