A randomised controlled provider‐blinded trial of community health workers in sickle cell anaemia: effects on haematologic variables and hydroxyurea adherence

Author(s):  
Wally R. Smith ◽  
Donna K. McClish ◽  
Richard Lottenberg ◽  
India Y. Sisler ◽  
Daniel Sop ◽  
...  
2021 ◽  
Vol 6 (11) ◽  
pp. e007205
Author(s):  
Jane E Yang ◽  
Diego Lassala ◽  
Jenny X Liu ◽  
Caroline Whidden ◽  
Isaac Holeman ◽  
...  

BackgroundProactive community case management (ProCCM) has shown promise to advance goals of universal health coverage (UHC). ProCCM community health workers (CHWs) face operational challenges when pursuing their goal of visiting every household in their service area at least twice monthly to proactively find sick patients. We developed a software extension (UHC Mode) to an existing CHW mobile application featuring user interface design improvements to support CHWs in planning daily home visits. We evaluated the effect of UHC Mode on minimum expected home visit coverage.MethodsWe conducted a parallel-group, two-arm randomised controlled trial of ProCCM CHWs in two separate regions in Mali. CHWs were randomly assigned to UHC Mode or the standard mobile application (control) with a 1:1 allocation. Randomisation was stratified by health catchment area. CHWs and other programme personnel were not masked to arm allocation. CHWs used their assigned intervention for 4 months. Using a difference-in-differences analysis, we estimated the mean change in minimum expected home visit coverage from preintervention to postintervention between arms.ResultsEnrolment occurred in January 2019. Of 199 eligible CHWs randomised to the intervention or control arm, 196 were enrolled and 195 were included in the analysis. Households whose CHW used UHC Mode had 2.41 times higher odds of minimum expected home visit coverage compared with households whose CHW used the control (95% CI 1.68 to 3.47; p<0.0005). Minimum expected home visit coverage in the UHC Mode arm increased 13.6 percentage points (95% CI 8.1 to 19.0) compared with the control arm.ConclusionOur findings suggest UHC Mode is an effective tool that can improve home visit coverage and promote progress towards UHC when implemented in the ProCCM context. User interface design of health information systems that supports health workers’ daily practices and meets their requirements can have a positive impact on health worker performance and home visit coverage.Trial registration numberNCT04106921.


Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 5831-5831
Author(s):  
Joan Corder-Mabe ◽  
Shirley Johnson ◽  
Wally R. Smith ◽  
Daniel Sop Mouaffo ◽  
Thokozeni Lipato

Abstract Background: Evidence is mounting for the effectiveness of community health workers (CHWs) at improving processes and outcomes of care in sickle cell disease (SCD) and other chronic diseases. But recognition is stymied by over 60 titles currently used for CHWs, by variable CHW roles and responsibilities in SCD and other disease entities, and by variations in populations and communities served by CHWs. Herein, we use an evidence review and consensus to advance a common framework and uniform definition of the functions of CHWs, that differentiates CHW roles and responsibilities. We offer the justification for this differentiation, and for certification, credentialing, education, licensure, and payment for CHW service in the US. Methods: To standardize the CHW intervention in the NHLBI-funded Start Healing in Patients with Hydroxyurea (SHIP-HU,R18HL112737) randomized controlled trial, we reviewed existing publications related to CHW efficacy. In order to synthesize and codify this efficacy evidence according to CHW occupational activities, we performed a rapid, narrative and tabular review of the clinical trials, meta-analyses and policy consensus reports summarizing over 200 CHW interventions to improve patient health status or care delivery. We built frequency tables to total how many mentions occurred of each of the specific roles, responsibilities, competencies, and behaviors utilized in these interventions, using a predetermined list built from a review of all the included interventions. Results: (Evidence table too large to show) Findings of our review and consensus: 1) the more frequently mentioned intervention behaviors might be more important or generally required of all CHWs, whereas the rarer behaviors might either be more specialized or might be less often required of all CHWs; 2) there is strong evidence that CHWs are effective in providing culturally competent health education to individuals and groups, as well as health system navigation and care coordination; 3) there is not strong evidence for the efficacy of CHWs in the provision of direct services; 4) Coaching and social support were less commonly mentioned than the above services; 5)Neither outreach, case finding, nor advocacy were often mentioned in interventions, and; 6) Participation and evaluation in research was mentioned least in interventions. Our consensus recommendation based on these data is for a common framework or taxonomy consisting of four levels of CHW function: Peer Community Health Worker (PCHW), General Community Health Worker (GCHW), Clinical Community Health Worker (CCHW), and Health Navigator (HN). Conclusions: Our proposed evidence-based CHW taxonomy standardizes definitions, provides categories into which to place workers, and delineates levels of service that, if tested, validated, and adopted, could allow national standards for CHW scope of practice, licensure, certification, and registration to practice. Disclosures No relevant conflicts of interest to declare.


Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 1310-1310 ◽  
Author(s):  
Nancy S. Green ◽  
Deepa Manwani ◽  
Luisa Soto ◽  
Yina Castillo ◽  
Karen Ireland ◽  
...  

Abstract Background: Chronic disease regimens for youth require self-management skills for a daily medication habit. Incomplete adherence to hydroxyurea (HU) is a treatment barrier for sickle cell disease (SCD) (Walsh KE, Pediatrics 2014). HU induction of fetal hemoglobin (HbF) is dose-dependent but not a standardized target (Ware RE, Hematology Am Soc Hematol Educ Program, 2015). In a previous 2-site retrospective analysis of youth with SCD, large deviation from historical personal best (PBest) HbF, a clinic-based form of maximum dose (Green NS, PBC, 2016), was common and correlated with increased acute hospital use. Here we hypothesized that: 1) A HU habit can develop through education and support of youth-parent dyads from a structured intervention of community health workers (CHW), augmented by text messaging; 2) Improved used will increase HbF; 3) The intervention is feasible and acceptable. Methods: We conducted a 2-site R21-funded randomized controlled feasibility trial (RCT), "Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABIT" (Smaldone A, Contemp Clin Trials, 2016)." Youth- parent dyads (youth ages 10-18) were recruited for the 6-month intervention. Eligibility required a ≥15% drop from PBest HbF on stable HU dose over the preceding year. Intervention dyads received a 6-month structured intervention of education and support by CHWs with home visits and text messaging, versus educational materials. Primary outcomes were HbF, % deviation from PBest HbF and HU pharmacy refills. Results: Using 2:1 randomization, 28 parent-youth dyads participated (18 intervention, 10 control): mean age 14.3±2.6 years, 42.9% female. At baseline, no differences were seen in HbF (10.5% vs. 13.4%, p=0.25), but deviation from PBest HbF was higher in the control group (-42.6%) than the intervention (18.1%, p=0.009). Using a growth model for % deviation from PBest HbF, the intervention group demonstrated a modest absolute improvement in deviation from PBest (2.2% per month higher in the intervention group), peaking at month 4 (p=0.31), and modest gain in mean HbF (3 versus 1.8). Four subjects exceeded their PBest. Compared to the year before intervention, pharmacy refills improved for the intervention group: 64.6% year prior, 80.7% (months 0 to 3), 85.9% (months >3 to 6), while the control group was unchanged (79.2% year prior, 83.6% months 0 to 3, 79.4% months >3 to 6). Intervention feasibility and acceptability by dyads were excellent. Conclusions: The 6-month pilot RCT "HABIT" may improve HU adherence measured by improved HbF, deviation from PBest and pharmacy refill, was feasible and acceptable, and suggests utility as an intervention. Based on these findings, a multi-center HABIT RCT of 1-year duration powered to test efficacy is planned. Funded by 5R21NR013745 (PIs Green, Smaldone) Figure Figure. Disclosures No relevant conflicts of interest to declare.


2016 ◽  
Vol 51 (1) ◽  
pp. S87-S98 ◽  
Author(s):  
Lewis L. Hsu ◽  
Nancy S. Green ◽  
E. Donnell Ivy ◽  
Cindy E. Neunert ◽  
Arlene Smaldone ◽  
...  

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