Chronic spinal cord injury causes upregulation of serotonin (5-HT)2A and 5-HT2C receptors in lumbosacral cord motoneurons

2017 ◽  
Vol 121 (1) ◽  
pp. 145-154 ◽  
Author(s):  
Nailong Cao ◽  
Jianshu Ni ◽  
Xiaohu Wang ◽  
Hongjian Tu ◽  
Baojun Gu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury ◽  
Injury Causes

Pharmacological Approaches to Chronic Spinal Cord Injury

2013 ◽  
Vol 19 (24) ◽  
pp. 4423-4436 ◽  
Author(s):  
Inge Steuer ◽  
Pascal Rouleau ◽  
Pierre Guertin
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

scholarly journals Use of a Combination Strategy to Improve Morphological and Functional Recovery in Rats With Chronic Spinal Cord Injury

2020 ◽  
Vol 11 ◽  
Author(s):  
Roxana Rodríguez-Barrera ◽  
Adrián Flores-Romero ◽  
Vinnitsa Buzoianu-Anguiano ◽  
Elisa Garcia ◽  
Karla Soria-Zavala ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Combination Strategy ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

scholarly journals Elevated levels of IgA and IgG2 in individuals with chronic spinal cord injury

2021 ◽  
pp. 1-11
Author(s):  
Aya Shnawa ◽  
Samuel Lee ◽  
Angelos Papatheodorou ◽  
Katie Gibbs ◽  
Adam Stein ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

scholarly journals The effects of a high-fat/high-carbohydrate meal on leukocyte populations in adults with chronic spinal cord injury

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Gabriel U. Dix ◽  
Garett S. Jackson ◽  
Kendra R. Todd ◽  
Jan W. van der Scheer ◽  
Jeremy J. Walsh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
High Fat ◽  
Chronic Spinal Cord Injury ◽  
High Carbohydrate ◽  
Cord Injury ◽  
Leukocyte Populations ◽  
Carbohydrate Meal

scholarly journals Systemic Inflammation and the Breakdown of Intestinal Homeostasis Are Key Events in Chronic Spinal Cord Injury Patients

2021 ◽  
Vol 22 (2) ◽  
pp. 744
Author(s):  
David Diaz ◽  
Elisa Lopez-Dolado ◽  
Sergio Haro ◽  
Jorge Monserrat ◽  
Carlos Martinez-Alonso ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bacterial Translocation ◽  
Binding Protein ◽  
Gut Barrier ◽  
Chronic Spinal Cord Injury ◽  
Fatty Acid Binding ◽  
Tnf Α ◽  
Cord Injury ◽  
Subset Distribution

Our aim was to investigate the subset distribution and function of circulating monocytes, proinflammatory cytokine levels, gut barrier damage, and bacterial translocation in chronic spinal cord injury (SCI) patients. Thus, 56 SCI patients and 28 healthy donors were studied. The levels of circulating CD14+highCD16−, CD14+highCD16+, and CD14+lowCD16+ monocytes, membrane TLR2, TLR4, and TLR9, phagocytic activity, ROS generation, and intracytoplasmic TNF-α, IL-1, IL-6, and IL-10 after lipopolysaccharide (LPS) stimulation were analyzed by polychromatic flow cytometry. Serum TNF-α, IL-1, IL-6 and IL-10 levels were measured by Luminex and LPS-binding protein (LBP), intestinal fatty acid-binding protein (I-FABP) and zonulin by ELISA. SCI patients had normal monocyte counts and subset distribution. CD14+highCD16− and CD14+highCD16+ monocytes exhibited decreased TLR4, normal TLR2 and increased TLR9 expression. CD14+highCD16− monocytes had increased LPS-induced TNF-α but normal IL-1, IL-6, and IL-10 production. Monocytes exhibited defective phagocytosis but normal ROS production. Patients had enhanced serum TNF-α and IL-6 levels, normal IL-1 and IL-10 levels, and increased circulating LBP, I-FABP, and zonulin levels. Chronic SCI patients displayed impaired circulating monocyte function. These patients exhibited a systemic proinflammatory state characterized by enhanced serum TNF-α and IL-6 levels. These patients also had increased bacterial translocation and gut barrier damage.

The impact of COVID-19 on community integration, quality of life, depression and anxiety in people with chronic spinal cord injury

2021 ◽  
pp. 1-10
Author(s):  
Alejandro García-Rudolph ◽  
Joan Saurí ◽  
Jaume López Carballo ◽  
Blanca Cegarra ◽  
Mark Andrew Wright ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Community Integration ◽  
Depression And Anxiety ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury ◽  
The Impact

scholarly journals Prevalence of deep venous thrombosis in patients with chronic spinal cord injury

1994 ◽  
Vol 75 (9) ◽  
pp. 965-968 ◽  
Author(s):  
Sun W. Kim ◽  
Joseph T. Charallel ◽  
Ke W. Park ◽  
Leonardo C. Bauerle ◽  
Chung C. Shang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury
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