scholarly journals Waterjet Ablation Therapy for Endoscopic Resection of prostate tissue trial (WATER) vs WATER II: comparing Aquablation therapy for benign prostatic hyperplasia in 30-80 and 80-150 mL prostates

2019 ◽  
Vol 125 (1) ◽  
pp. 112-122 ◽  
Author(s):  
David-Dan Nguyen ◽  
Neil Barber ◽  
Mo Bidair ◽  
Peter Gilling ◽  
Paul Anderson ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Endoscopic Resection ◽  
Prostatic Hyperplasia ◽  
Prostate Tissue ◽  
Ablation Therapy

scholarly journals High-Fat Diet Induced Gut Microbiota Alterations Associating With Ghrelin/Jak2/Stat3 Up-Regulation to Promote Benign Prostatic Hyperplasia Development

2021 ◽  
Vol 9 ◽  
Author(s):  
Meng Gu ◽  
Chong Liu ◽  
TianYe Yang ◽  
Ming Zhan ◽  
Zhikang Cai ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Benign Prostatic Hyperplasia ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Prostatic Hyperplasia ◽  
Prostate Tissue ◽  
High Fat ◽  
Ghrelin Receptor

The role of high-fat diet (HFD) induced gut microbiota alteration and Ghrelin as well as their correlation in benign prostatic hyperplasia (BPH) were explored in our study. The gut microbiota was analyzed by 16s rRNA sequencing. Ghrelin levels in serum, along with Ghrelin and Ghrelin receptor in prostate tissue of mice and patients with BPH were measured. The effect of Ghrelin on cell proliferation, apoptosis, and induction of BPH in mice was explored. Our results indicated that BPH mice have the highest ratio of Firmicutes and Bacteroidetes induced by HFD, as well as Ghrelin level in serum and prostate tissue was significantly increased compared with control. Elevated Ghrelin content in the serum and prostate tissue of BPH patients was also observed. Ghrelin promotes cell proliferation while inhibiting cell apoptosis of prostate cells. The effect of Ghrelin on enlargement of the prostate was found almost equivalent to that of testosterone propionate (TP) which may be attenuated by Ghrelin receptor antagonist YIL-781. Ghrelin could up-regulate Jak2/pJak2/Stat3/pStat3 expression in vitro and in vivo. Our results suggested that Gut microbiota may associate with Ghrelin which plays an important role in activation of Jak2/Stat3 in BPH development. Gut microbiota and Ghrelin might be pathogenic factors for BPH and could be used as a target for mediation.

Rezūm steam ablation therapy for benign prostatic hyperplasia: Initial results from the United Kingdom

2019 ◽  
Vol 18 (1) ◽  
pp. e1489-e1490
Author(s):  
M. Johnston ◽  
T. Shah ◽  
A. Emara ◽  
T. Gehring ◽  
T. Farmer ◽  
...  
Keyword(s):  
United Kingdom ◽  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Ablation Therapy ◽  
The United Kingdom ◽  
Initial Results

scholarly journals Chemical Profiles of The Active Fraction From Prinsepia Utilis Royle Leaves and Its Anti-Benign Prostatic Hyperplasia Evaluation in Animal Models

2021 ◽  
Author(s):  
Ying Peng ◽  
Chongsheng Peng ◽  
Yang Wu ◽  
Chongzhi Sun ◽  
Xiaobo Li
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Growth Factor ◽  
Animal Models ◽  
Water Extract ◽  
Serum Levels ◽  
Prostatic Hyperplasia ◽  
Relative Content ◽  
Prostate Tissue ◽  
Active Fraction ◽  
Tnf Α

Abstract Background The Prinsepia utilis Royle leaves (P. utilis) is a folk herb used for benign prostatic hyperplasia (BPH) control by ethnic minorities for centuries in China with rich in resources. Our previous studies have confirmed the anti-BPH effect of its water extract (QCJ) and the active fraction (Fr. B) separated from the QCJ by animal test. The Fr. B from P. utilis maybe as a candidate for BPH control. Methods In this study, the chemical ingredients of Fr. B were identified by UPLC-QTOF-MS, and quantified by HPLC. Murine animal models were divided into 8 groups, Sham rats, BPH rats, BPH rats administered with Finasteride (1 mg/kg), BPH rats administered with Pule'an (460 mg/kg), BPH rats administered with Low QCJ (860 mg (dry leaf)/kg), BPH rats administered with High QCJ (2580 mg (dry leaf)/kg), BPH rats administered with Low Fr. B (160 mg (dry leaf)/kg), BPH rats administered with High Fr. B (480 mg (dry leaf)/kg). The expression of vascular endothelial growth factor (VEGF) in the prostate tissue of rats was tested, and serum levels of dihydrotestosterone (DHT), testosterone (T), estradiol (E2), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and total superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), malondialdehyde (MDA) in prostate homogenate were measured. One-way ANOVA followed by LSD was used for statistical analysis. Results The BPH rats treated by Fr. B exhibited the significant reductions of VEGF and MDA levels, as well the significant increases of SOD, GSH-Px and CAT in the prostate tissue after 28 day administration (P < 0.05). Moreover, Fr. B significantly reduced DHT, DHT/E2 ratio, TNF-α, while increased T levels in serum of BPH rats (P < 0.05). UPLC-QTOF-MS analysis revealed 10 flavonoids as the key constituents of this fraction, which accounted for 54.96% of all substance of Fr. B. Compound 1 was with a relative content of 11.1%, and compound 2 was with a relative content of 13% in Fr. B. Conclusions These results indicated that the Fr. B obtained from P. Utilis alleviated the symptoms of BPH rats through multiple mechanisms including reduction of DHT/E2 ratio, inhibition of growth factor, anti-inflammation and anti-oxidation, in which flavonoids might be the key constituents. It supported the hypothesis that the Fr. B should be further explored as a candidate for BPH patients.

Prostate Tissue Composition and Response to Finasteride in Men With Symptomatic Benign Prostatic Hyperplasia

1997 ◽  
pp. 2171-2178 ◽  
Author(s):  
Leonard S. Marks ◽  
Alan W. Partin ◽  
Glenn J. Gormley ◽  
Frederick J. Dorey ◽  
Erlinda D. Shery ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Prostate Tissue ◽  
Tissue Composition ◽  
Symptomatic Benign Prostatic Hyperplasia

scholarly journals Gamma Irradiated Rhodiola sachalinensis Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3981
Author(s):  
Qi Xin ◽  
Mi-Jin Kwon ◽  
Ju-Woon Lee ◽  
Kwan-Soo Kim ◽  
Hao Chen ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Smooth Muscle Actin ◽  
Similar Efficacy ◽  
Prostatic Hyperplasia ◽  
Prostate Tissue ◽  
Control Group ◽  
Rhodiola Sachalinensis ◽  
Prostate Weight ◽  
Prostatic Enlargement ◽  
Gamma Irradiated

The effect of Rhodiola sachalinensis Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection of 20 mg/kg of testosterone propionate (TP) to induce BPH. Then, the testosterone only group received testosterone, the testosterone + finasteride group received testosterone and finasteride (5 mg/kg), the testosterone + HKC group received testosterone and HKC extract (500 mg/kg). Prostate weight and the dihydrotestosterone (DHT) levels in serum or prostate tissue were determined. The mRNA expressions of 5-alpha reductase (AR) in prostate tissue were also measured. Compared to the control group, prostate weight was significantly improved in the TP group and decreased in the HKC and finasteride-treated groups. Furthermore, the mRNA expression of 5-AR in the prostate was significantly reduced in the HKC and finasteride-treated groups. Similarly, the expression levels of α-smooth muscle actin (α-SMA) and cytokeratin, which are associated with prostatic enlargement in the HKC and finasteride groups, were much lower than in the TP group. HKC treatment showed similar efficacy to finasteride treatment on rats with testosterone-induced BPH. HKC may be explored as a potential new drug for BPH treatment.

scholarly journals A Rare Prostatic Diagnosis of an Old Man: A Pure Prostatic Leiomyoma

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
W. M. van Ulden-Bleumink ◽  
P. G. B. Dom ◽  
B. P. M. Ramakers ◽  
N. P. H. van Adrichem
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Urinary Retention ◽  
Benign Tumor ◽  
Histopathological Examination ◽  
Transrectal Ultrasound ◽  
Prostatic Hyperplasia ◽  
Prostate Tissue ◽  
Gross Hematuria ◽  
Retropubic Prostatectomy ◽  
Rare Benign Tumor

A pure leiomyoma of the prostate is a rare benign tumor. An 82-year-old man was referred to our urology department with gross hematuria and complete urinary retention. Examination revealed a benign prostatic hyperplasia. Transrectal ultrasound showed a prostate of 125 mL. Serum PSA was 1.9 µg/L. A simple retropubic prostatectomy was performed. Histopathological examination showed a pure leiomyoma of the prostate, without the presence of glandular prostate tissue. The diagnosis, characteristics, and treatment of this tumor are described.

Sign in / Sign up

Export Citation Format

Share Document