Background: To characterize the safety and efficacy of Holmium Laser
Enucleation of Prostate (HoLEP) in patients with large prostates
(>100ml) at high risk for thromboembolic events (TE)
resuming antithrombotic treatment (AT) in the early postoperative
period. Methods: Data for 378 men with large prostates treated with
HoLEP for symptomatic benign prostatic hyperplasia between December 2016
and July 2020 were reviewed retrospectively. Of the patients, 134 had
been receiving AT, (anticoagulant (AC), n=51; antiplatelet (AP), n=83).
AT was resumed within 24 hours postoperatively. We determined pre-,
peri-, and postoperative parameters, functional outcome, and adverse
events for the 3-month period postoperatively in patients receiving AC
and AP; and compared results with 203 patients without AT. Results:
Patients receiving AC and AP were older (p=0.015) and had a higher
median ASA score (p<0.001). Objective voiding parameters
(Qmax, PVR) and urinary symptoms (IPSS, QoL) improved in the three
groups (p<0.001). Median enucleation and morcellation
efficiencies were 1.58 (IQR:0.87-3.13) and 5 (IQR:1-8.08), median
catheterization and hospitalization time was 2 days (IQR:2-3) and 3 days
(IQR:3-4), respectively. The perioperative results were similar in the
three groups. Overall, one patient in the AP group required blood
transfusion at 4 days postoperatively due to clot retention and
significant hemoglobin decrease (p=0.216). There was no adverse TE in
any patient within 3-month postoperatively. Conclusion: HoLEP is an
effective and safe method in patients with a high risk of TE whose AT is
discontinued for surgery, as it enables AT to be resumed as soon as
possible.