scholarly journals Short-term treatment with the GABAAreceptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome

2013 ◽  
Vol 169 (5) ◽  
pp. 963-973 ◽  
Author(s):  
D Colas ◽  
B Chuluun ◽  
D Warrier ◽  
M Blank ◽  
D Z Wetmore ◽  
...  
Keyword(s):  
Mouse Model ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Cognitive Benefit

scholarly journals Short-term treatment with dabigatran alters protein expression patterns in a late-stage tau-based Alzheimer's disease mouse model

2020 ◽  
Vol 24 ◽  
pp. 100862
Author(s):  
Jaclyn Iannucci ◽  
Shelby L. Johnson ◽  
Mark Majchrzak ◽  
Benjamin J. Barlock ◽  
Fatemeh Akhlaghi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Protein Expression ◽  
Late Stage ◽  
Expression Patterns ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment

Short-term treatment with flumazenil restores long-term object memory in a mouse model of Down syndrome

2017 ◽  
Vol 140 ◽  
pp. 11-16 ◽  
Author(s):  
Damien Colas ◽  
Bayarsaikhan Chuluun ◽  
Craig C. Garner ◽  
H. Craig Heller
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Object Memory

Adrenal phenotype in TPIT insufficient animals cannot be restored by short-term treatment with physiological doses of ACTH and N-POMC

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
S Klammer ◽  
D Schulte ◽  
M Fassnacht ◽  
S Hahner ◽  
AM Pulichino ◽  
...  
Keyword(s):  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment

scholarly journals KIDNEY INJURY MOLECULE-1 AS AN EARLY AMIKACIN-INDUCED NEPHROTOXICITY MARKER IN PATIENTS WITH SEPSIS HOSPITALIZED IN THE INTENSIVE CARE UNIT

2019 ◽  
pp. 277-279
Author(s):  
TRISNI UNTARI DEWI ◽  
INSTIATY . ◽  
RUDIANTO SEDONO ◽  
GESTINA ALISKA ◽  
MUHAMMAD KHIFZHON AZWAR ◽  
...  
Keyword(s):  
Intensive Care ◽  
Kidney Injury ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Safe Level ◽  
Study Results ◽  
Early Biomarker ◽  
Kidney Injury Molecule 1 ◽  
Trough Plasma

Objective: This study sought to determine the correlation between trough plasma amikacin concentrations and urinary normalized kidney injurymolecule-1 (KIM-1) concentrations as an early biomarker of nephrotoxicity in patients with sepsis who are hospitalized in an intensive care unit.Methods: In this pilot study, 12 patients with sepsis were treated with amikacin 1000 mg/day between May 2015 and September 2015. The correlationbetween trough plasma amikacin concentrations measured after the third dose and the elevation of urinary normalized KIM-1 concentrations afterthe third amikacin dose relative to the first/second dose was evaluated.Results: In total, three patients had trough plasma amikacin concentrations exceeding the safe level (>10 μg/ml). Furthermore, eight patientsdisplayed higher normalized KIM-1 concentrations after third dose than after the first/second dose; however, there was no correlation betweentrough amikacin concentrations and the elevation of urinary normalized KIM-1 concentrations (r=0.3, p=0.3).Conclusion: The study results illustrated that short-term treatment with an amikacin dose of 1000 mg/day was generally safe in patients with sepsis.

Instrumentation in Voice Assessment and Treatment

1997 ◽  
Vol 6 (4) ◽  
pp. 9-16 ◽  
Author(s):  
Alison Behrman ◽  
Robert F. Orlikoff
Keyword(s):  
Clinical Practice ◽  
Scientific Method ◽  
Term Treatment ◽  
Treatment Goals ◽  
Short Term ◽  
Short Term Treatment ◽  
Voice Assessment ◽  
Assessment And Treatment ◽  
Computer Based ◽  
The Voice

Sophisticated, computer-based instrumentation has become increasingly available to the voice clinician. Yet substantial questions remain regarding its clinical necessity and usefulness. A theoretical model based on the scientific method is developed as a framework that can be used to guide the clinician in the selection and application of instrumental measures. Using the process of hypothesis testing, instrumentation is presented as an integral component of clinical practice. The uses of instrumental measures, and their relevance to long- and short-term treatment goals, are addressed. Clinical examples are presented to illustrate the incorporation of instrumentation and the scientific method into assessment and treatment.

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