scholarly journals Pim1 supports human colorectal cancer growth during glucose deprivation by enhancing the Warburg effect

2018 ◽  
Vol 109 (5) ◽  
pp. 1468-1479 ◽  
Author(s):  
Meng Zhang ◽  
Tingting Liu ◽  
Hui Sun ◽  
Weiwei Weng ◽  
Qiongyan Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Warburg Effect ◽  
Glucose Deprivation ◽  
Cancer Growth ◽  
Human Colorectal Cancer ◽  
The Warburg Effect

scholarly journals miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect

2012 ◽  
Vol 28 (4) ◽  
pp. 1346-1352 ◽  
Author(s):  
YAN SUN ◽  
XIAOPING ZHAO ◽  
YUHONG ZHOU ◽  
YU HU
Keyword(s):  
Colorectal Cancer ◽  
Warburg Effect ◽  
Cancer Growth ◽  
The Warburg Effect

scholarly journals Promotion of the Warburg effect is associated with poor benefit from adjuvant chemotherapy in colorectal cancer

2020 ◽  
Vol 111 (2) ◽  
pp. 658-666
Author(s):  
Masashi Kitazawa ◽  
Tomohisa Hatta ◽  
Yusuke Sasaki ◽  
Kazuhiko Fukui ◽  
Koji Ogawa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adjuvant Chemotherapy ◽  
Warburg Effect ◽  
The Warburg Effect

scholarly journals Dysfunction of an energy sensor NFE2L1 triggers uncontrollable AMPK signal and glucose metabolism reprogramming

2021 ◽  
Author(s):  
Qiufang Yang ◽  
Wenshan Zhao ◽  
Yadi Xing ◽  
Peng Li ◽  
Xiaowen Zhou ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Warburg Effect ◽  
Metabolic Diseases ◽  
Energy State ◽  
Glucose Deprivation ◽  
Cancer Development ◽  
Energy Sensor ◽  
Dual Sensor ◽  
Glycolysis Pathway ◽  
The Warburg Effect

AbstractNFE2L1 (also called Nrf1) acts a core regulator of redox signaling and metabolism homeostasis, and thus its dysfunction results in multiple systemic metabolic diseases. However, the molecular mechanism(s) by which NFE2L1 regulates glycose and lipid metabolism is still elusive. Here, we found that the loss of NFE2L1 in human HepG2 cells led to a lethal phenotype upon glucose deprivation. The uptake of glucose was also affected by NFE2L1 deficiency. Further experiments unveiled that although the glycosylation of NFE2L1 was monitored through the glycolysis pathway, it enabled to sense the energy state and directly interacted with AMPK. These indicate that NFE2L1 can serve as a dual sensor and regulator of glucose homeostasis. In-depth sights into transcriptome, metabolome and seahorse data further unraveled that glucose metabolism was reprogrammed by disruption of NFE2L1, so as to aggravate the Warburg effect in NFE2L1-silenced hepatoma cells, along with the mitochondrial damage observed under the electron microscope. Collectively, these demonstrate that disfunction of NFE2L1 triggers the uncontrollable signaling by AMPK towards glucose metabolism reprogramming in the liver cancer development.

scholarly journals Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer

2021 ◽  
Vol 22 (12) ◽  
pp. 6434
Author(s):  
Aldona Kasprzak
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Glucose Metabolism ◽  
Warburg Effect ◽  
Mapk Signaling ◽  
Colorectal Carcinogenesis ◽  
Insulin Like Growth Factor ◽  
Aberrant Expression ◽  
The Warburg Effect

Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide, characterized by unfavorable curative effect and poor prognosis. Epidemiological data re-vealed that CRC risk is increased in patients with metabolic syndrome (MetS) and its serum components (e.g., hyperglycemia). High glycemic index diets, which chronically raise post-prandial blood glucose, may at least in part increase colon cancer risk via the insulin/insulin-like growth factor 1 (IGF-1) signaling pathway. However, the underlying mechanisms linking IGF-1 and MetS are still poorly understood. Hyperactivated glucose uptake and aerobic glycolysis (the Warburg effect) are considered as a one of six hallmarks of cancer, including CRC. However, the role of insulin/IGF-1 signaling during the acquisition of the Warburg metabolic phenotypes by CRC cells is still poorly understood. It most likely results from the interaction of multiple processes, directly or indirectly regulated by IGF-1, such as activation of PI3K/Akt/mTORC, and Raf/MAPK signaling pathways, activation of glucose transporters (e.g., GLUT1), activation of key glycolytic enzymes (e.g., LDHA, LDH5, HK II, and PFKFB3), aberrant expression of the oncogenes (e.g., MYC, and KRAS) and/or overexpression of signaling proteins (e.g., HIF-1, TGF-β1, PI3K, ERK, Akt, and mTOR). This review describes the role of IGF-1 in glucose metabolism in physiology and colorectal carcinogenesis, including the role of the insulin/IGF system in the Warburg effect. Furthermore, current therapeutic strategies aimed at repairing impaired glucose metabolism in CRC are indicated.

scholarly journals Specific up-regulation of p21 by a small active RNA sequence suppresses human colorectal cancer growth

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 25055-25065 ◽  
Author(s):  
Lu-Lu Wang ◽  
Hui-Hui Guo ◽  
Yun Zhan ◽  
Chen-Lin Feng ◽  
Shuai Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Growth ◽  
Human Colorectal Cancer ◽  
Rna Sequence

scholarly journals Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer

2021 ◽  
Author(s):  
Kelly Offermans ◽  
Josien CA Jenniskens ◽  
Colinda CJM Simons ◽  
Iryna Samarska ◽  
Gregorio E Fazzi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Warburg Effect ◽  
The Warburg Effect

scholarly journals Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications

2018 ◽  
Vol 19 (9) ◽  
pp. 2752 ◽  
Author(s):  
Ibrahim El Halabi ◽  
Rachelle Bejjany ◽  
Rihab Nasr ◽  
Deborah Mukherji ◽  
Sally Temraz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Ascorbic Acid ◽  
Cancer Cells ◽  
Warburg Effect ◽  
Tumour Regression ◽  
Therapeutic Concept ◽  
Therapeutic Benefits ◽  
Potential Benefits ◽  
The Warburg Effect

Given the safety and potential benefits of intravenous ascorbic acid (AA) administration in cancer patients, there is merit in further exploring this therapeutic concept. In this review, we discuss the potential benefits of intravenous AA administration on colorectal cancer and we specifically focus on its effect on glycolysis in mutant and wild type RAS. We perform a PubMed and Ovid MEDLINE search using ascorbic acid, intravenous vitamin C, KRAS mutation, BRAF mutation and colorectal cancer (CRC) as keywords. At the cellular level, colorectal cancer cells undergo a metabolic shift called the Warburg effect to allow for more glucose absorption and utilization of glycolysis. This shift also allows AA to enter which leads to a disruption in the Warburg effect and a shutdown of the downstream KRAS pathway in mutated KRAS colon cancer cells. At the clinical level, AA is associated with tumour regression in advanced disease and improved tolerability and side effects of standard therapy. Based on these findings, we conclude that further clinical trials are needed on a larger scale to examine the therapeutic benefits of AA in colon cancer.

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