scholarly journals Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer

2021 ◽  
Author(s):  
Kelly Offermans ◽  
Josien CA Jenniskens ◽  
Colinda CJM Simons ◽  
Iryna Samarska ◽  
Gregorio E Fazzi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Warburg Effect ◽  
The Warburg Effect

scholarly journals Promotion of the Warburg effect is associated with poor benefit from adjuvant chemotherapy in colorectal cancer

2020 ◽  
Vol 111 (2) ◽  
pp. 658-666
Author(s):  
Masashi Kitazawa ◽  
Tomohisa Hatta ◽  
Yusuke Sasaki ◽  
Kazuhiko Fukui ◽  
Koji Ogawa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adjuvant Chemotherapy ◽  
Warburg Effect ◽  
The Warburg Effect

scholarly journals Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer

2021 ◽  
Vol 22 (12) ◽  
pp. 6434
Author(s):  
Aldona Kasprzak
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Glucose Metabolism ◽  
Warburg Effect ◽  
Mapk Signaling ◽  
Colorectal Carcinogenesis ◽  
Insulin Like Growth Factor ◽  
Aberrant Expression ◽  
The Warburg Effect

Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide, characterized by unfavorable curative effect and poor prognosis. Epidemiological data re-vealed that CRC risk is increased in patients with metabolic syndrome (MetS) and its serum components (e.g., hyperglycemia). High glycemic index diets, which chronically raise post-prandial blood glucose, may at least in part increase colon cancer risk via the insulin/insulin-like growth factor 1 (IGF-1) signaling pathway. However, the underlying mechanisms linking IGF-1 and MetS are still poorly understood. Hyperactivated glucose uptake and aerobic glycolysis (the Warburg effect) are considered as a one of six hallmarks of cancer, including CRC. However, the role of insulin/IGF-1 signaling during the acquisition of the Warburg metabolic phenotypes by CRC cells is still poorly understood. It most likely results from the interaction of multiple processes, directly or indirectly regulated by IGF-1, such as activation of PI3K/Akt/mTORC, and Raf/MAPK signaling pathways, activation of glucose transporters (e.g., GLUT1), activation of key glycolytic enzymes (e.g., LDHA, LDH5, HK II, and PFKFB3), aberrant expression of the oncogenes (e.g., MYC, and KRAS) and/or overexpression of signaling proteins (e.g., HIF-1, TGF-β1, PI3K, ERK, Akt, and mTOR). This review describes the role of IGF-1 in glucose metabolism in physiology and colorectal carcinogenesis, including the role of the insulin/IGF system in the Warburg effect. Furthermore, current therapeutic strategies aimed at repairing impaired glucose metabolism in CRC are indicated.

scholarly journals Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications

2018 ◽  
Vol 19 (9) ◽  
pp. 2752 ◽  
Author(s):  
Ibrahim El Halabi ◽  
Rachelle Bejjany ◽  
Rihab Nasr ◽  
Deborah Mukherji ◽  
Sally Temraz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Ascorbic Acid ◽  
Cancer Cells ◽  
Warburg Effect ◽  
Tumour Regression ◽  
Therapeutic Concept ◽  
Therapeutic Benefits ◽  
Potential Benefits ◽  
The Warburg Effect

Given the safety and potential benefits of intravenous ascorbic acid (AA) administration in cancer patients, there is merit in further exploring this therapeutic concept. In this review, we discuss the potential benefits of intravenous AA administration on colorectal cancer and we specifically focus on its effect on glycolysis in mutant and wild type RAS. We perform a PubMed and Ovid MEDLINE search using ascorbic acid, intravenous vitamin C, KRAS mutation, BRAF mutation and colorectal cancer (CRC) as keywords. At the cellular level, colorectal cancer cells undergo a metabolic shift called the Warburg effect to allow for more glucose absorption and utilization of glycolysis. This shift also allows AA to enter which leads to a disruption in the Warburg effect and a shutdown of the downstream KRAS pathway in mutated KRAS colon cancer cells. At the clinical level, AA is associated with tumour regression in advanced disease and improved tolerability and side effects of standard therapy. Based on these findings, we conclude that further clinical trials are needed on a larger scale to examine the therapeutic benefits of AA in colon cancer.

scholarly journals Metformin prevents DMH ‐induced colorectal cancer in diabetic rats by reversing the warburg effect

2015 ◽  
Vol 4 (11) ◽  
pp. 1730-1741 ◽  
Author(s):  
Yanglei Jia ◽  
Zengyi Ma ◽  
Xiaofei Liu ◽  
Wenjing Zhou ◽  
Shan He ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Warburg Effect ◽  
Diabetic Rats ◽  
The Warburg Effect

scholarly journals Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1α

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Lijiang Ji ◽  
Weixing Shen ◽  
Feng Zhang ◽  
Jie Qian ◽  
Jie Jiang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cancer Cell ◽  
Warburg Effect ◽  
Lactate Production ◽  
Colorectal Cancer Cell ◽  
Cell Cycle Distribution ◽  
Cancer Cell Growth ◽  
The Warburg Effect

Abstract Background Some natural compounds inhibit cancer cell growth in various cancer cell lines with fewer side effects than traditional chemotherapy. Here, we explore the pharmacological effects and mechanisms of worenine (isolated from Coptis chinensis) against colorectal cancer. Methods The effects of worenine on colorectal cancer cell proliferation, colony formation and cell cycle distribution were measured. Glycolysis was investigated by examining glucose uptake and consumption, lactate production, and the activities and expressions of glycolysis enzymes (PFK-L, HK2 and PKM2). HIF-1α was knocked down and stimulated in vitro to investigate the underlying mechanisms. Results Worenine somewhat altered the glucose metabolism and glycolysis (Warburg effect) of cancer cells. Its anti-cancer effects and capability to reverse the Warburg effect were similar to those of HIF-1α siRNA and weakened by deferoxamine (an HIF-1α agonist). Conclusion It is suggested that worenine targets HIF-1α to inhibit colorectal cancer cell growth, proliferation, cell cycle progression and the Warburg effect.

scholarly journals miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect

2012 ◽  
Vol 28 (4) ◽  
pp. 1346-1352 ◽  
Author(s):  
YAN SUN ◽  
XIAOPING ZHAO ◽  
YUHONG ZHOU ◽  
YU HU
Keyword(s):  
Colorectal Cancer ◽  
Warburg Effect ◽  
Cancer Growth ◽  
The Warburg Effect

Importance of the Microbiota Inhibitory Mechanism on the Warburg Effect in Colorectal Cancer Cells

2019 ◽  
Vol 51 (3) ◽  
pp. 738-747 ◽  
Author(s):  
Majid Eslami ◽  
Sina Sadrifar ◽  
Mohsen Karbalaei ◽  
Masoud Keikha ◽  
Nazarii M. Kobyliak ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Warburg Effect ◽  
Inhibitory Mechanism ◽  
Colorectal Cancer Cells ◽  
The Warburg Effect

scholarly journals Genetic Mutations and Non-Coding RNA-Based Epigenetic Alterations Mediating the Warburg Effect in Colorectal Carcinogenesis

Biology ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 847
Author(s):  
Batoul Abi Zamer ◽  
Wafaa Abumustafa ◽  
Mawieh Hamad ◽  
Azzam A. Maghazachi ◽  
Jibran Sualeh Muhammad
Keyword(s):  
Colorectal Cancer ◽  
Glucose Metabolism ◽  
Warburg Effect ◽  
Colorectal Carcinogenesis ◽  
Genetic Mutations ◽  
Epigenetic Alterations ◽  
Therapeutic Approaches ◽  
Non Coding Rna ◽  
Gradual Process ◽  
The Warburg Effect

Colorectal cancer (CRC) development is a gradual process defined by the accumulation of numerous genetic mutations and epigenetic alterations leading to the adenoma-carcinoma sequence. Despite significant advances in the diagnosis and treatment of CRC, it continues to be a leading cause of cancer-related deaths worldwide. Even in the presence of oxygen, CRC cells bypass oxidative phosphorylation to produce metabolites that enable them to proliferate and survive—a phenomenon known as the “Warburg effect”. Understanding the complex glucose metabolism in CRC cells may support the development of new diagnostic and therapeutic approaches. Here we discuss the most recent findings on genetic mutations and epigenetic modulations that may positively or negatively regulate the Warburg effect in CRC cells. We focus on the non-coding RNA (ncRNA)-based epigenetics, and we present a perspective on the therapeutic relevance of critical molecules and ncRNAs mediating the Warburg effect in CRC cells. All the relevant studies were identified and assessed according to the genes and enzymes mediating the Warburg effect. The findings summarized in this review should provide a better understanding of the relevance of genetic mutations and the ncRNA-based epigenetic alterations to CRC pathogenesis to help overcome chemoresistance.

Energy balance-related factors and risk of colorectal cancer expressing different levels of proteins involved in the Warburg-effect

2021 ◽  
pp. cebp.EPI-21-0678-E.2021
Author(s):  
Josien C.A Jenniskens ◽  
Kelly Offermans ◽  
Colinda CJM Simons ◽  
Iryna Samarska ◽  
Gregorio E Fazzi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Energy Balance ◽  
Warburg Effect ◽  
Related Factors ◽  
Different Levels ◽  
The Warburg Effect

scholarly journals Pim1 supports human colorectal cancer growth during glucose deprivation by enhancing the Warburg effect

2018 ◽  
Vol 109 (5) ◽  
pp. 1468-1479 ◽  
Author(s):  
Meng Zhang ◽  
Tingting Liu ◽  
Hui Sun ◽  
Weiwei Weng ◽  
Qiongyan Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Warburg Effect ◽  
Glucose Deprivation ◽  
Cancer Growth ◽  
Human Colorectal Cancer ◽  
The Warburg Effect
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