scholarly journals dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells

2020 ◽  
Vol 112 (1) ◽  
pp. 422-432
Author(s):  
Tatsushi Yokogawa ◽  
Wakako Yano ◽  
Sayaka Tsukioka ◽  
Akiko Osada ◽  
Takeshi Wakasa ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cancer Cells ◽  
Thymidylate Synthase ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Thymidylate Synthase Inhibitor ◽  
Synthase Inhibitor

scholarly journals Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery

2010 ◽  
Vol 70 (22) ◽  
pp. 9339-9348 ◽  
Author(s):  
Shinji Kuroda ◽  
Toshiya Fujiwara ◽  
Yasuhiro Shirakawa ◽  
Yasumoto Yamasaki ◽  
Shuya Yano ◽  
...  
Keyword(s):  
Dna Repair ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Human Cancer ◽  
Oncolytic Adenovirus ◽  
Human Cancer Cells

Synergy between the non-classical thymidylate synthase inhibitor AG337 (ThymitaqR) and cisplatin in human colon and ovarian cancer cells

1996 ◽  
Vol 7 (7) ◽  
pp. 752-757 ◽  
Author(s):  
Eric Raymond ◽  
Siham Djelloul ◽  
Christine Buquet-Fagot ◽  
Jan Mester ◽  
Christian Gespach
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Thymidylate Synthase ◽  
Human Colon ◽  
Ovarian Cancer Cells ◽  
Thymidylate Synthase Inhibitor ◽  
Synthase Inhibitor

scholarly journals Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells

2006 ◽  
Vol 5 (12) ◽  
pp. 3085-3095 ◽  
Author(s):  
Ju-Hee Lee ◽  
Jung-Hyun Park ◽  
Yeonjoo Jung ◽  
Jee-Hyun Kim ◽  
Hyun-Soon Jong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Histone Deacetylase ◽  
Thymidylate Synthase ◽  
Histone Deacetylase Inhibitor ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Deacetylase Inhibitor

scholarly journals Exosome component 1 cleaves single-stranded DNA and sensitizes kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Qiaoling Liu ◽  
Qi Xiao ◽  
Zhen Sun ◽  
Bo Wang ◽  
Lina Wang ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cancer Cells ◽  
Therapeutic Strategy ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Human Cancer ◽  
Renal Clear Cell Carcinoma ◽  
Dna Damages ◽  
Human Cancer Cells ◽  
Polymerase Inhibitor

Targeting DNA repair pathway offers an important therapeutic strategy for Homo sapiens (human) cancers. However, the failure of DNA repair inhibitors to markedly benefit patients necessitates the development of new strategies. Here, we show that exosome component 1 (EXOSC1) promotes DNA damages and sensitizes human kidney renal clear cell carcinoma (KIRC) cells to DNA repair inhibitor. Considering that endogenous source of mutation (ESM) constantly assaults genomic DNA and likely sensitize human cancer cells to the inhibitor, we first analyzed the statistical relationship between the expression of individual genes and the mutations for KIRC. Among the candidates, EXOSC1 most notably promoted DNA damages and subsequent mutations via preferentially cleaving C site(s) in single-stranded DNA. Consistently, EXOSC1 was more significantly correlated with C>A transversions in coding strands than these in template strands in human KIRC. Notably, KIRC patients with high EXOSC1 showed a poor prognosis, and EXOSC1 sensitized human cancer cells to poly(ADP-ribose) polymerase inhibitor. These results show that EXOSC1 acts as an ESM in KIRC, and targeting EXOSC1 might be a potential therapeutic strategy.

scholarly journals Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells

1995 ◽  
Vol 71 (6) ◽  
pp. 1151-1157 ◽  
Author(s):  
BC Pestalozzi ◽  
CJ McGinn ◽  
TJ Kinsella ◽  
JC Drake ◽  
MC Glennon ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cancer Cells ◽  
Thymidylate Synthase ◽  
Human Cancer ◽  
Cell Cycle Phase ◽  
Cycle Phase ◽  
Human Cancer Cells ◽  
Protein Levels

scholarly journals Disruption of telomere equilibrium sensitises human cancer cells to DNA repair inhibition and radiation

2016 ◽  
Vol 118 ◽  
pp. S49
Author(s):  
S. Venkatesan ◽  
R. Lal Gurung ◽  
S. Sameni ◽  
S. Sethu ◽  
M.P. Hande
Keyword(s):  
Dna Repair ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

scholarly journals Glucose deprivation increases nuclear DNA repair protein Ku and resistance to radiation induced oxidative stress in human cancer cells

2009 ◽  
Vol 27 (2) ◽  
pp. 93-101 ◽  
Author(s):  
Jie Li ◽  
Roashan Ayene ◽  
Kathleen M. Ward ◽  
Eswarkumar Dayanandam ◽  
Iraimoudi S. Ayene
Keyword(s):  
Oxidative Stress ◽  
Dna Repair ◽  
Cancer Cells ◽  
Nuclear Dna ◽  
Human Cancer ◽  
Glucose Deprivation ◽  
Human Cancer Cells ◽  
Repair Protein ◽  
Dna Repair Protein ◽  
Radiation Induced

scholarly journals DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity

2012 ◽  
Vol 7 (1) ◽  
Author(s):  
HakJae Kim ◽  
JinHo Kim ◽  
EuiKyu Chie ◽  
Park DaYoung ◽  
InAh Kim ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cancer Cells ◽  
Dna Methyltransferase ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Dna Methyltransferase Inhibitors ◽  
Repair Activity
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