scholarly journals Increased killer B cells in chronic HCV infection may lead to autoimmunity and increased viral load

2018 ◽  
Vol 193 (2) ◽  
pp. 183-193 ◽  
Author(s):  
N. Eiza ◽  
E. Zuckerman ◽  
M. Carlebach ◽  
T. Rainis ◽  
Y. Goldberg ◽  
...  
Keyword(s):  
Viral Load ◽  
B Cells ◽  
Hcv Infection ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals HCV Infection and B-Cell Lymphomagenesis

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Masahiko Ito ◽  
Hideki Kusunoki ◽  
Keiko Mochida ◽  
Kazunari Yamaguchi ◽  
Toshiaki Mizuochi
Keyword(s):  
B Cells ◽  
B Cell ◽  
Chronic Infection ◽  
Recent Literature ◽  
Epidemiological Data ◽  
Mixed Cryoglobulinemia ◽  
Hcv Infection ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Hepatitis C virus (HCV) has been recognized as a major cause of chronic liver diseases worldwide. It has been suggested that HCV infects not only hepatocytes but also mononuclear lymphocytes including B cells that express the CD81 molecule, a putative HCV receptor. HCV infection of B cells is the likely cause of B-cell dysregulation disorders such as mixed cryoglobulinemia, rheumatoid factor production, and B-cell lymphoproliferative disorders that may evolve into non-Hodgkin's lymphoma (NHL). Epidemiological data indicate an association between HCV chronic infection and the occurrence of B-cell NHL, suggesting that chronic HCV infection is associated at least in part with B-cell lymphomagenesis. In this paper, we aim to provide an overview of recent literature, including our own, to elucidate a possible role of HCV chronic infection in B-cell lymphomagenesis.

IFN induction vs standard IFN for chronic HCV infection — a randomised study of patients with genotype 2B/3A, low viral load and without cirrhosis

2001 ◽  
Vol 34 ◽  
pp. 16
Author(s):  
Kristian Bjoro ◽  
Helge Bell ◽  
Kjell B. Hellum ◽  
Bjorn Myrvang ◽  
Kjell Skaug ◽  
...  
Keyword(s):  
Viral Load ◽  
Hcv Infection ◽  
Randomised Study ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals Clinical, Biochemical and Virological Profile of Patients with Chronic Hepatitis C Virus Infection - A Study from University Hospital in Nepal

2015 ◽  
Vol 4 (1) ◽  
pp. 32-35
Author(s):  
Dipesh Gurubacharya ◽  
Mohan Khadka ◽  
Khadga B Shreshta ◽  
Prem Khadga ◽  
Sashi Sharma
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Drug Use ◽  
Injection Drug Use ◽  
Hcv Infection ◽  
Genotype 3 ◽  
Hcv Genotypes ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Introduction: Hepatitis C virus (HCV) infection is a major public health challenge. It is a major cause for cirrhosis and hepatocellular carcinoma worldwide. Both the genotype and viral load of HCV determine the choice of therapy as well as outcome of therapy. The aim of this study was to evaluate clinical, biochemical and virological profile and association of HCV genotypes with viral load and liver biochemical profile.Material and Methods: This was descriptive observational study of chronic HCV infected patients who attended at the outpatient clinic of Department of Gastroenterology of TUTH, IOM from April 2013 to November 2014. During this study period 38 patients with chronic HCV infection were analyzed. Clinical profile, possible risk factors for transmission of HCV infection and liver biochemical profile were recorded. Virological profile included HCV viral load and HCV genotypes.Results: Out of 38 patients 34(89.5%) were male and 4(10.5%) were female. Injection drug use (IDU) was the most common mode for acquisition of HCV infection (55.3%). Genotype 3 was found in 21(55.26%) patients and genotype 1 was found in 17(44.74%) patients. There was no significant association between HCV genotypes and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level. And also there was no significant association between HCV viral load and different HCV genotypes.Conclusions: In our study HCV genotype 3 was the most prevalent genotype in patients with chronic HCV infection. Injection drug use was identified as most common identifiable risk factor for transmission of HCV infection. There was no significant association between different HCV genotypes and serum ALT, AST level and HCV viral load. Journal of Nobel College of Medicine Vol.4(1) 2015: 32-35

Fluctations in viral load (HCV RNA) are relatively insignificant in untreated patients with chronic HCV infection

1996 ◽  
Vol 3 (2) ◽  
pp. 75-78 ◽  
Author(s):  
T. T. Nguyen ◽  
A. Sedghi-Vaziri ◽  
L. B. Wilkes ◽  
T. Mondala ◽  
P. J. Pockros ◽  
...  
Keyword(s):  
Viral Load ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

VIRAL LOAD AT 12 WEEKS OF TREATMENT IS A STRONG PROGNOSTIC MARKER OF RESPONSE IN PATIENTS WITH CHRONIC HCV INFECTION

2011 ◽  
Vol 22 ◽  
pp. S51-S52
Author(s):  
Ioannis Ketikoglou ◽  
Konstantinos Thomas ◽  
Christos Koutsianas ◽  
Georgios Alafostergios ◽  
Stamatia Athanasopoulou ◽  
...  
Keyword(s):  
Viral Load ◽  
Prognostic Marker ◽  
Hcv Infection ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

708 THE ROLE OF REGULATORY B-CELLS IN CHRONIC HCV INFECTION AND THEIR RELATION TO HCV-ASSOCIATED AUTOIMMUNITY

2010 ◽  
Vol 52 ◽  
pp. S275
Author(s):  
E. Zuckerman ◽  
C. Dashkovsky ◽  
R. Peri ◽  
E. Sabo ◽  
E. Toubi
Keyword(s):  
B Cells ◽  
Hcv Infection ◽  
Regulatory B Cells ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals The TNFA -308G>A and IL10 -1082A>G Polymorphisms as Predictive Biomarkers of Chronic HCV Infection

2020 ◽  
Author(s):  
Angélica Menezes Santiago ◽  
Ednelza da Silva Graça Amoras ◽  
Maria Alice Freitas Queiroz ◽  
Simone Regina Souza da Silva Conde ◽  
Izaura Maria Vieira Cayres-Vallinoto ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Predictive Biomarkers ◽  
Hcv Infection ◽  
Genetic Changes ◽  
Polymorphic Genotype ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Abstract Background: Genetic changes may induce dysregulated cytokine production and affect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-inflammatory cytokines determines the outcome of infection. This study evaluated the TNFA -308G>A and IL10 -1082A>G polymorphisms in the susceptibility and progress of chronic hepatitis CMethods: The study included 101 samples from patients with chronic hepatitis C and 300 samples from healthy donors. Polymorphisms were typed by real-time PCR and were analyzed for associations with histopathological parameters (according to METAVIR classification) and HCV viral load. Results: The polymorphic genotype for the TNFA -308G>A variant was not present in the group of patients with chronic hepatitis C and was associated with protection against HCV infection (p = 0.0477). Patients with the polymorphic genotype of the IL10 -1082A>G polymorphism had higher HCV viral load than wild-type patients (p = 0.0428). Neither polymorphism was associated with different levels of necroinflammatory activity or fibrosis scores. Conclusion: The polymorphic genotype at TNFA -308G>A protected against chronic HCV infection, and the polymorphic genotype at the IL10 -1082A>G variant was associated with viral persistence.

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