IFN induction vs standard IFN for chronic HCV infection - a randomised study of patients with genotype 2B/3A, low viral load and without cirrhosis

Introduction: Hepatitis C virus (HCV) infection is a major public health challenge. It is a major cause for cirrhosis and hepatocellular carcinoma worldwide. Both the genotype and viral load of HCV determine the choice of therapy as well as outcome of therapy. The aim of this study was to evaluate clinical, biochemical and virological profile and association of HCV genotypes with viral load and liver biochemical profile.Material and Methods: This was descriptive observational study of chronic HCV infected patients who attended at the outpatient clinic of Department of Gastroenterology of TUTH, IOM from April 2013 to November 2014. During this study period 38 patients with chronic HCV infection were analyzed. Clinical profile, possible risk factors for transmission of HCV infection and liver biochemical profile were recorded. Virological profile included HCV viral load and HCV genotypes.Results: Out of 38 patients 34(89.5%) were male and 4(10.5%) were female. Injection drug use (IDU) was the most common mode for acquisition of HCV infection (55.3%). Genotype 3 was found in 21(55.26%) patients and genotype 1 was found in 17(44.74%) patients. There was no significant association between HCV genotypes and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level. And also there was no significant association between HCV viral load and different HCV genotypes.Conclusions: In our study HCV genotype 3 was the most prevalent genotype in patients with chronic HCV infection. Injection drug use was identified as most common identifiable risk factor for transmission of HCV infection. There was no significant association between different HCV genotypes and serum ALT, AST level and HCV viral load. Journal of Nobel College of Medicine Vol.4(1) 2015: 32-35

Download Full-text

Fluctations in viral load (HCV RNA) are relatively insignificant in untreated patients with chronic HCV infection

Journal of Viral Hepatitis ◽

10.1111/j.1365-2893.1996.tb00084.x ◽

1996 ◽

Vol 3 (2) ◽

pp. 75-78 ◽

Cited By ~ 91

Author(s):

T. T. Nguyen ◽

A. Sedghi-Vaziri ◽

L. B. Wilkes ◽

T. Mondala ◽

P. J. Pockros ◽

...

Keyword(s):

Viral Load ◽

Hcv Infection ◽

Hcv Rna ◽

Chronic Hcv Infection ◽

Chronic Hcv

Download Full-text

VIRAL LOAD AT 12 WEEKS OF TREATMENT IS A STRONG PROGNOSTIC MARKER OF RESPONSE IN PATIENTS WITH CHRONIC HCV INFECTION

European Journal of Internal Medicine ◽

10.1016/s0953-6205(11)60210-0 ◽

2011 ◽

Vol 22 ◽

pp. S51-S52

Author(s):

Ioannis Ketikoglou ◽

Konstantinos Thomas ◽

Christos Koutsianas ◽

Georgios Alafostergios ◽

Stamatia Athanasopoulou ◽

...

Keyword(s):

Viral Load ◽

Prognostic Marker ◽

Hcv Infection ◽

Chronic Hcv Infection ◽

Chronic Hcv

Download Full-text

A prospective cross-over study comparing the effect of mycophenolate versus azathioprine on allograft function and viral load in liver transplant recipients with recurrent chronic HCV infection

Liver Transplantation ◽

10.1002/lt.20000 ◽

2004 ◽

Vol 10 (1) ◽

pp. 52-57 ◽

Cited By ~ 60

Author(s):

Amany Zekry ◽

Margret Gleeson ◽

Seren Guney ◽

Geoffrey W. McCaughan

Keyword(s):

Viral Load ◽

Liver Transplant ◽

Hcv Infection ◽

Transplant Recipients ◽

Allograft Function ◽

Chronic Hcv Infection ◽

Chronic Hcv ◽

Liver Transplant Recipients

Download Full-text

The TNFA -308G>A and IL10 -1082A>G Polymorphisms as Predictive Biomarkers of Chronic HCV Infection

10.21203/rs.3.rs-64090/v1 ◽

2020 ◽

Author(s):

Angélica Menezes Santiago ◽

Ednelza da Silva Graça Amoras ◽

Maria Alice Freitas Queiroz ◽

Simone Regina Souza da Silva Conde ◽

Izaura Maria Vieira Cayres-Vallinoto ◽

...

Keyword(s):

Chronic Hepatitis ◽

Viral Load ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Predictive Biomarkers ◽

Hcv Infection ◽

Genetic Changes ◽

Polymorphic Genotype ◽

Chronic Hcv Infection ◽

Chronic Hcv

Abstract Background: Genetic changes may induce dysregulated cytokine production and affect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-inflammatory cytokines determines the outcome of infection. This study evaluated the TNFA -308G>A and IL10 -1082A>G polymorphisms in the susceptibility and progress of chronic hepatitis CMethods: The study included 101 samples from patients with chronic hepatitis C and 300 samples from healthy donors. Polymorphisms were typed by real-time PCR and were analyzed for associations with histopathological parameters (according to METAVIR classification) and HCV viral load. Results: The polymorphic genotype for the TNFA -308G>A variant was not present in the group of patients with chronic hepatitis C and was associated with protection against HCV infection (p = 0.0477). Patients with the polymorphic genotype of the IL10 -1082A>G polymorphism had higher HCV viral load than wild-type patients (p = 0.0428). Neither polymorphism was associated with different levels of necroinflammatory activity or fibrosis scores. Conclusion: The polymorphic genotype at TNFA -308G>A protected against chronic HCV infection, and the polymorphic genotype at the IL10 -1082A>G variant was associated with viral persistence.

Download Full-text

Patterns of viral load decline with telaprevir-based therapy in patients with genotype 1 chronic HCV infection

Journal of Clinical Virology ◽

10.1016/j.jcv.2013.12.011 ◽

2014 ◽

Vol 59 (3) ◽

pp. 148-155

Author(s):

Gaston Picchio ◽

Sandra De Meyer ◽

Inge Dierynck ◽

Anne Ghys ◽

Linda Gritz ◽

...

Keyword(s):

Viral Load ◽

Hcv Infection ◽

Genotype 1 ◽

Chronic Hcv Infection ◽

Chronic Hcv

Download Full-text

TNFA -308G>A and IL10 -1082A>G Polymorphisms as Predictive Biomarkers of Chronic HCV Infection

10.21203/rs.3.rs-537692/v1 ◽

2021 ◽

Author(s):

Angélica Menezes Santiago ◽

Ednelza da Silva Graça Amoras ◽

Maria Alice Freitas Queiroz ◽

Simone Regina Souza da Silva Conde ◽

Izaura Maria Vieira Cayres-Vallinoto ◽

...

Keyword(s):

Chronic Hepatitis ◽

Viral Load ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Predictive Biomarkers ◽

Hcv Infection ◽

Genetic Changes ◽

Polymorphic Genotype ◽

Chronic Hcv Infection ◽

Chronic Hcv

Abstract Genetic changes may induce dysregulated cytokine production and affect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-inflammatory cytokines determines the outcome of infection. This study evaluated the TNFA − 308G > A and IL10 -1082A > G polymorphisms in the susceptibility and progress of chronic hepatitis C. The study included 101 samples from patients with chronic hepatitis C and 300 samples from healthy donors. Polymorphisms were typed by real-time PCR and were analyzed for associations with histopathological parameters (according to METAVIR classification) and HCV viral load. The polymorphic genotype for the TNFA − 308G > A variant was not present in the group of patients with chronic hepatitis C and was associated with protection against HCV infection (p = 0.0477). Patients with the polymorphic genotype of the IL10 -1082A > G polymorphism had higher HCV viral load than wild-type patients (p = 0.0428). Neither polymorphism was associated with different levels of necroinflammatory activity or fibrosis scores. The polymorphic genotype at TNFA − 308G > A protected against chronic HCV infection, and the polymorphic genotype at the IL10 -1082A > G variant was associated with viral persistence.

Download Full-text