Obstructive sleep apnoea, insulin resistance and adipocytokines

Obstructive sleep apnoea (OSA) is associated with increased insulin resistance. Triglyceride-glucose index (TyG) is a simple marker of insulin resistance; however, it has been investigated only by two studies in OSA. The aim of this study was to evaluate TyG in non-diabetic, non-obese patients with OSA. A total of 132 patients with OSA and 49 non-OSA control subjects were included. Following a diagnostic sleep test, fasting blood was taken for the analysis of the lipid profile and glucose concentrations. TyG was calculated as ln(triglyceride [mg/dL] × glucose [mg/dL]/2). Comparison analyses between OSA and control groups were adjusted for age, gender, body mass index (BMI) and smoking. TyG was higher in men (p < 0.01) and in ever-smokers (p = 0.02) and it was related to BMI (ρ = 0.33), cigarette pack-years (ρ = 0.17), apnoea–hypopnoea index (ρ = 0.38), oxygen desaturation index (ρ = 0.40), percentage of total sleep time spent with oxygen saturation below 90% (ρ = 0.34), and minimal oxygen saturation (ρ = −0.29; all p < 0.05). TyG values were significantly higher in OSA (p = 0.02) following adjustment for covariates. OSA is independently associated with higher TyG values which are related to disease severity in non-obese, non-diabetic subjects. However, the value of TyG in clinical practice should be evaluated in follow-up studies in patients with OSA.

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Effect of CPAP on insulin resistance in patients with obstructive sleep apnoea and type 2 diabetes

Thorax ◽

10.1136/thx.2007.090415 ◽

2008 ◽

Vol 63 (4) ◽

pp. 384-385

Author(s):

I A Harsch ◽

E G Hahn ◽

S Pour Schahin

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Obstructive Sleep Apnoea ◽

Sleep Apnoea ◽

Obstructive Sleep

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Insulin Resistance in Obstructive Sleep Apnoea Syndrome

Solunum ◽

10.5152/solunum.2013.008 ◽

2013 ◽

pp. 45-49

Author(s):

Selma Aydogan Eroglu ◽

Tulin Kuyucu ◽

Hacer Okur ◽

Mevlut Karatas

Keyword(s):

Insulin Resistance ◽

Obstructive Sleep Apnoea ◽

Sleep Apnoea ◽

Obstructive Sleep Apnoea Syndrome ◽

Sleep Apnoea Syndrome ◽

Obstructive Sleep

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Daytime sleepiness in patients with obstructive sleep apnoea syndrome and its correlation to insulin resistance

10.1183/13993003.congress-2016.pa2346 ◽

2016 ◽

Author(s):

Dimosthenis Lykouras ◽

Kleanthis Theodoropoulos ◽

Olga Lagiou ◽

Michail Lykouras ◽

Fotios Sampsonas ◽

...

Keyword(s):

Insulin Resistance ◽

Obstructive Sleep Apnoea ◽

Daytime Sleepiness ◽

Sleep Apnoea ◽

Obstructive Sleep Apnoea Syndrome ◽

Sleep Apnoea Syndrome ◽

Obstructive Sleep

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Obstructive sleep apnoea, insulin resistance and sleepiness

Thorax ◽

10.1136/thx.2008.099689 ◽

2008 ◽

Vol 63 (11) ◽

pp. 939-940 ◽

Cited By ~ 2

Author(s):

M. S M Ip

Keyword(s):

Insulin Resistance ◽

Obstructive Sleep Apnoea ◽

Sleep Apnoea ◽

Obstructive Sleep

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Obstructive sleep apnoea syndrome, plasma adiponectin levels, and insulin resistance

Clinical Endocrinology ◽

10.1111/j.1365-2265.2005.02407.x ◽

2006 ◽

Vol 64 (1) ◽

pp. 12-19 ◽

Cited By ~ 84

Author(s):

Shinya Makino ◽

Hiroshi Handa ◽

Koji Suzukawa ◽

Masayoshi Fujiwara ◽

Masaharu Nakamura ◽

...

Keyword(s):

Insulin Resistance ◽

Obstructive Sleep Apnoea ◽

Sleep Apnoea ◽

Obstructive Sleep Apnoea Syndrome ◽

Plasma Adiponectin ◽

Sleep Apnoea Syndrome ◽

Obstructive Sleep

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The prevalence of syndrome Z (the interaction of obstructive sleep apnoea with the metabolic syndrome) in a tertiary care center, Gujarat, India

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20184760 ◽

2018 ◽

Vol 5 (6) ◽

pp. 1476

Author(s):

Bhavesh R. Sureja ◽

Gaurav D. Bhambhani

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Obstructive Sleep Apnoea ◽

Care Center ◽

Tertiary Care ◽

Sleep Apnoea ◽

Entire Group ◽

Tertiary Care Center ◽

The Metabolic Syndrome ◽

Obstructive Sleep

Background: The interaction of obstructive sleep apnoea (OSA) with vascular risk factors is known as syndrome Z which is also known as the metabolic syndrome or the insulin resistance syndrome and these include the hypertension, central obesity, insulin resistance and hyperlipidaemia. The objective of the present study was to investigate the prevalence and severity of syndrome Z at tertiary care center.Methods: This prospective study was conducted among 40 eligible patients between May and July 2018 at the tertiary care center included adult patients >18years of age. Overnight fasting glucose and lipid levels were measured, and baseline anthropometric data recorded. All sleep studies were scored and reported by a sleep physician. OSA was deemed to be present if the respiratory disturbance index (RDI) was >5, with mild, moderate and severe categories classified according to the Chicago criteria.Results: Mean age of participants was 52.7years, 77.5% were male, Mean BMI and waist circumference were 29.2kg/m2 and 113.8cm respectively. Almost 92.5% participants were known case of HTN, 85.0% were DM and 67.5% Dyslipidemia. Around 60.0% participants were belonged to severe grade of OSAS and 7 (17.5%) patients who fulfilled all five criteria for the diagnosis of the metabolic syndrome had severe OSAS. The prevalence of OSA in the entire group was 95.0%.Conclusions: The prevalence of syndrome Z in present study participants was very high. With the help of history and polysomnogram, metabolic syndrome should be screened for OSA. Early diagnosis and treatment of OSA is the essential part in the treatment of metabolic syndrome and hence CAD.

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Increased Resting Energy Expenditure and Insulin Resistance in Male Patients With Moderate-to Severe Obstructive Sleep Apnoea

Physiological Research ◽

10.33549/physiolres.933277 ◽

2016 ◽

pp. 969-977 ◽

Cited By ~ 3

Author(s):

M. BRÚSIK ◽

Z. ŠTRBOVÁ ◽

D. PETRÁŠOVÁ ◽

P. POBEHA ◽

Z. KUKLIŠOVÁ ◽

...

Keyword(s):

Insulin Resistance ◽

Energy Expenditure ◽

Obstructive Sleep Apnoea ◽

Resting Energy Expenditure ◽

Sleep Apnoea ◽

Fat Free Mass ◽

Model Assessment ◽

Obstructive Sleep ◽

Male Patients ◽

Resting Energy

Obstructive sleep apnoea (OSA) has been associated with disturbances in energy metabolism and insulin resistance, nevertheless, the links between OSA severity, resting energy expenditure (REE) and insulin resistance (homeostasis model assessment, HOMA-IR) remained unexplored. Therefore, we investigated the effects of OSA severity on REE, and relationships between REE and HOMA-IR in patients with OSA. Forty men [mean (SD) age 49.4 (11.4) years] underwent overnight polysomnography; REE was assessed using indirect calorimetry. REE adjusted for fat-free mass (FFM) was higher in patients with moderate-to severe OSA [n=24; body mass index (BMI) 31.1 (2.7) kg.m-2; apnoea-hypopnoea index (AHI)≥15 episodes.h 1] compared to participants with no clinically significant OSA (n=16; BMI 30.3 (2.2) kg.m-2; AHI<15 episodes.h-1) [median (interquartile range) 30.4 (26.1-31.3) versus 25.8 (24.6-27.3) kcal.kg-1.24 h-1, p=0.005)]. AHI and oxygen desaturation index (ODI) were directly related to REE/FFM (p=0.001; p<0.001, respectively) and to HOMA-IR (p<0.001 for both). In stepwise multiple linear models, REE/FFM was independently predicted by ODI (p<0.001) and age (p=0.028) (R2=0.346); HOMA-IR was independently predicted by ODI only (p<0.001, R2=0.457). In conclusion, male patients with moderate-to severe OSA have increased REE paralleled by impaired insulin sensitivity. Severity of nocturnal intermittent hypoxia reflected by ODI is an independent predictor of REE/FFM and HOMA-IR.

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