Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model

Glycogen Synthase Kinase 3Β ◽

Synaptic Structure

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

Journal of Neuroscience Research ◽

10.1002/jnr.21787 ◽

2008 ◽

Vol 86 (15) ◽

pp. 3265-3274 ◽

Cited By ~ 154

Author(s):

C.G. Jolivalt ◽

C.A. Lee ◽

K.K. Beiswenger ◽

J.L. Smith ◽

M. Orlov ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Signaling Pathway ◽

Insulin Signaling ◽

Glycogen Synthase ◽

Insulin Signaling Pathway ◽

Glycogen Synthase Kinase 3 ◽

Diabetic Mice ◽

The Brain

Treadmill exercise decreases incidence of Alzheimer’s disease by suppressing glycogen synthase kinase-3β expression in streptozotocin-induced diabetic rats

Journal of Exercise Rehabilitation ◽

10.12965/jer.150198 ◽

2015 ◽

Vol 11 (2) ◽

pp. 87-94 ◽

Cited By ~ 9

Author(s):

Dae-Young Kim ◽

Sun-Young Jung ◽

Tae-Woon Kim ◽

Kwang-Sik Lee ◽

Kijeong Kim

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Treadmill Exercise ◽

Glycogen Synthase ◽

Diabetic Rats ◽

The Role of Glycogen Synthase Kinase 3β in Alzheimer’s Disease, with Implications in Drug Design

New Developments in Medicinal Chemistry ◽

10.2174/978160805127411001010057 ◽

2012 ◽

pp. 57-69

Author(s):

Adriana Mieco Namba ◽

Carlos Henrique Tomich de Paula da Silva

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Drug Design ◽

Glycogen Synthase ◽

Glycogen synthase kinase-3β and tau genes interact in Alzheimer's disease

Annals of Neurology ◽

10.1002/ana.21476 ◽

2008 ◽

Vol 64 (4) ◽

pp. 446-454 ◽

Cited By ~ 48

Author(s):

John B. J. Kwok ◽

Clement T. Loy ◽

Gillian Hamilton ◽

Edmond Lau ◽

Marianne Hallupp ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Glycogen Synthase ◽

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ◽

10.1016/j.bbadis.2013.06.012 ◽

2013 ◽

Vol 1832 (12) ◽

pp. 1913-1921 ◽

Cited By ~ 61

Author(s):

P. Hemachandra Reddy

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Glycogen Synthase ◽

Neuronal Damage ◽

Synaptic Dysfunction ◽

Mechanism of Glycogen Synthase Kinase-3β alterations by Alzheimer’s disease amyloid β peptides

Pharmacological Reports ◽

10.1016/s1734-1140(11)70688-0 ◽

2011 ◽

Vol 63 (5) ◽

pp. 1296

Author(s):

Martyna Songin ◽

Magdalena Cieślik ◽

Magdalena Gąssowska ◽

Grzegorz A. Czapski ◽

Joanna B. Strosznajder

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Glycogen Synthase ◽

Amyloid Β ◽

Glycogen Synthase Kinase-3 Modulates Neurite Outgrowth in Cultured Neurons: Possible Implications for Neurite Pathology in Alzheimer's Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-1999-1602 ◽

1999 ◽

Vol 1 (6) ◽

pp. 361-378 ◽

Cited By ~ 41

Author(s):

Juan Ramón Muñoz-Montaño ◽

Filip Lim ◽

Francisco J. Moreno ◽

Jesús Avila ◽

Javier Díaz-Nido

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Neurite Outgrowth ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase 3 ◽

Cultured Neurons

Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer’s Disease Multitarget Drug Discovery?

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c00931 ◽

2020 ◽

Author(s):

Angela De Simone ◽

Vincenzo Tumiatti ◽

Vincenza Andrisano ◽

Andrea Milelli

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Drug Discovery ◽

Glycogen Synthase ◽

Gold Rush ◽

Arylbenzofurans from the Root Bark of Morus alba as Triple Inhibitors of Cholinesterase, β-Site Amyloid Precursor Protein Cleaving Enzyme 1, and Glycogen Synthase Kinase-3β: Relevance to Alzheimer’s Disease

ACS Omega ◽

10.1021/acsomega.9b00198 ◽

2019 ◽

Vol 4 (4) ◽

pp. 6283-6294 ◽

Cited By ~ 8

Author(s):

Pradeep Paudel ◽

Su Hui Seong ◽

Yajuan Zhou ◽

Manh Tuan Ha ◽

Byung Sun Min ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Precursor Protein ◽

Glycogen Synthase ◽

Morus Alba ◽

Precursor Protein ◽

Root Bark ◽

Glycogen Synthase Kinase 3β Phosphorylates Alzheimer's Disease-Specific Ser396of Microtubule-Associated Protein Tau by a Sequential Mechanism†

Biochemistry ◽

10.1021/bi051634r ◽

2006 ◽

Vol 45 (10) ◽

pp. 3125-3133 ◽

Cited By ~ 74

Author(s):

Tong Li ◽

Hemant K. Paudel

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase 3Β ◽

Protein Tau ◽

Microtubule Associated Protein Tau ◽

Sequential Mechanism ◽

Disease Specific