Regenerative efficacy of fibroblast growth factor for the treatment of aged vocal fold: From animal model to clinical application

2020 ◽  
Vol 46 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Myung Jin Ban ◽  
Seung Chul Lee ◽  
Jae Hong Park ◽  
Ki Nam Park ◽  
Hee Kyung Kim ◽  
...  
Keyword(s):  
Animal Model ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Clinical Application ◽  
Vocal Fold ◽  
Fibroblast Growth

Low Serum Levels of Fibroblast Growth Factor 2 in Gunn Rats: A Hyperbilirubinemia Animal Model of Schizophrenic Symptoms

2020 ◽  
Vol 19 (7) ◽  
pp. 503-508
Author(s):  
Maiko Hayashida ◽  
Sadayuki Hashioka ◽  
Kenji Hayashida ◽  
Shoko Miura ◽  
Keiko Tsuchie ◽  
...  
Keyword(s):  
Animal Model ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Wistar Rats ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Normal Strain ◽  
Fibroblast Growth ◽  
Gunn Rats

Background: Fibroblast growth factor (FGF) 2 (also referred to as basic FGF) is a multifunctional growth factor that plays a pivotal role in the pro-survival, pro-migration and pro-differentiation of neurons. Method: Because alterations in FGF2 levels are suggested to contribute to the pathogenesis schizophrenia, we investigated serum levels of FGF2 in the Gunn rat, a hyperbilirubinemia animal model of schizophrenic symptoms. Results: The enzyme-linked immunosorbent assay showed that the serum levels of FGF2 in Gunn rats were 5.09 ± 0.236 pg/mL, while those in the normal strain Wistar rats were 11.90 ± 2.142 pg/mL. The serum FGF2 levels in Gunn rats were significantly lower than those in Wistar rats. We also measured serum levels of unconjugated bilirubin (UCB) and found a significant negative correlation between UCB and FGF2 at serum levels in all the rats studied. Conclusion: Since it is known that FGF2 regulates dopaminergic neurons and have anti-neuroinflammatory effects, our finding suggests that low FGF2 levels may contribute to the pathogenesis of schizophrenia, in which disbalanced dopamin-ergic signaling and neuroinflammation are supposed to play certain roles.

scholarly journals Treatment of acute vocal fold scar with local injection of basic fibroblast growth factor: a canine study

2010 ◽  
Vol 130 (7) ◽  
pp. 844-850 ◽  
Author(s):  
Atsushi Suehiro ◽  
Shigeru Hirano ◽  
Yo Kishimoto ◽  
Bernard Rousseau ◽  
Tatsuo Nakamura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Vocal Fold ◽  
Local Injection ◽  
Fibroblast Growth ◽  
Vocal Fold Scar ◽  
Canine Study

scholarly journals In vitro evaluation of a basic fibroblast growth factor‐containing hydrogel toward vocal fold lamina propria scar treatment

2017 ◽  
Vol 106 (3) ◽  
pp. 1258-1267 ◽  
Author(s):  
Josh D. Erndt‐Marino ◽  
Andrea C. Jimenez‐Vergara ◽  
Patricia Diaz‐Rodriguez ◽  
Jonathan Kulwatno ◽  
Juan Felipe Diaz‐Quiroz ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Lamina Propria ◽  
Basic Fibroblast Growth Factor ◽  
Vocal Fold ◽  
Fibroblast Growth ◽  
In Vitro Evaluation ◽  
Scar Treatment

Effects of Basic Fibroblast Growth Factor on Rat Vocal Fold Fibroblasts

2010 ◽  
Vol 119 (10) ◽  
pp. 690-696 ◽  
Author(s):  
Atsushi Suehiro ◽  
Shigeru Hirano ◽  
Yo Kishimoto ◽  
Ichiro Tateya ◽  
Bernard Rousseau ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Vocal Fold ◽  
Fibroblast Growth
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