scholarly journals Role of specific IgE on staphylococcal enterotoxin B in chronic rhinosinusitis severity

2020 ◽  
Author(s):  
Suk Won Chang ◽  
Jeong Jin Park ◽  
Chi Sang Hwang ◽  
Jae Sung Nam ◽  
Jong‐Gyun Ha ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Specific Ige ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

scholarly journals Role of specific IgE on staphylococcal enterotoxin B in chronic rhinosinusitis severity

2020 ◽  
Author(s):  
Suk Won Chang ◽  
Jeong Jin Park ◽  
Chi Sang Hwang ◽  
Jaesung Nam ◽  
Jong Gyun Ha ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Specific Ige ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

scholarly journals Memory T cells are anergic to the superantigen staphylococcal enterotoxin B.

1992 ◽  
Vol 176 (2) ◽  
pp. 575-579 ◽  
Author(s):  
W T Lee ◽  
E S Vitetta
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Staphylococcal Enterotoxin ◽  
Peripheral Tolerance ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

We have used staphylococcal enterotoxin B (SEB) to study the role of naive and memory T cells in the induction of peripheral tolerance. After administration of SEB to mice, the numbers of naive and memory T cells increase, as does the proportion of memory T cells, which are unresponsive to further stimulation with SEB in vitro. In addition, memory T cells generated in response to conventional antigen, which proliferate and provide help to B cells in the presence of the conventional antigen, fail to respond to superantigen. Hence, memory T cells, in general, are anergized by SEB. These results suggest that SEB-induced activation and anergy reflect the combined responses of naive and memory T cells. The differential activation vs. anergy of naive and memory T cells by superantigen may be related to cytokine production and may play an important role in the etiology of autoimmune diseases or immunodeficiency diseases such as acquired immune deficiency syndrome.

scholarly journals Role of Endogenous Interleukin-12 in Immune Response to Staphylococcal Enterotoxin B in Mice

2001 ◽  
Vol 69 (9) ◽  
pp. 5949-5952 ◽  
Author(s):  
Fanny N. Lauw ◽  
Sandrine Florquin ◽  
Peter Speelman ◽  
Sander J. H. van Deventer ◽  
Tom van der Poll
Keyword(s):  
Immune Response ◽  
Gamma Interferon ◽  
Staphylococcal Enterotoxin ◽  
Interleukin 12 ◽  
Staphylococcal Enterotoxin B ◽  
Induced Responses ◽  
Independent Mechanism ◽  
Enterotoxin B

ABSTRACT In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.

Possible Role of Staphylococcal Enterotoxin B in the Pathogenesis of Autoimmune Diseases

2015 ◽  
Vol 28 (7) ◽  
pp. 354-359 ◽  
Author(s):  
Jing Li ◽  
Jie Yang ◽  
Yu-wei Lu ◽  
Song Wu ◽  
Ming-rui Wang ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

Role of Staphylococcal Enterotoxin B on the Differentiation of Regulatory T Cells in Nasal Polyposis

2014 ◽  
Vol 28 (1) ◽  
pp. e17-e24 ◽  
Author(s):  
Soo-Na Cho ◽  
Chang-Hwa Song ◽  
Jun Jin ◽  
Sung Ha Kim ◽  
Ki-Sang Rha ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Nasal Polyposis ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

scholarly journals The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin B-induced shock in mice.

1994 ◽  
Vol 180 (3) ◽  
pp. 1153-1158 ◽  
Author(s):  
S Florquin ◽  
Z Amraoui ◽  
C Dubois ◽  
J Decuyper ◽  
M Goldman
Keyword(s):  
Nitric Oxide ◽  
Intraperitoneal Administration ◽  
Serum Levels ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Protective Effects ◽  
Ifn Gamma ◽  
Enterotoxin B

Nitric oxide (NO) synthesis during experimental endotoxemia has been shown to have both deleterious and beneficial effects. In the present study, we analyzed the in vivo production and the regulatory role of NO in the shock syndrome induced by staphylococcal enterotoxin B (SEB) in mice. First, we found that intraperitoneal administration of 100 micrograms SEB in BALB/c mice induced a massive synthesis of NO as indicated by high serum levels of nitrite (NO2-) and nitrate (NO3-) peaking 16 h after SEB injection. The inhibition of NO2- and NO3- release in mice injected with anti-tumor necrosis factor (TNF) and/or anti-interferon gamma (IFN-gamma) monoclonal antibody (mAb) before SEB challenge revealed that both cytokines were involved in SEB-induced NO overproduction. In vitro experiments indicated that NO synthase (NOS) inhibition by N-nitro-L-arginine methyl ester (L-NAME) enhanced IFN-gamma and TNF production by splenocytes in response to SEB. A similar effect was observed in vivo as treatment of mice with L-NAME resulted in increased IFN-gamma and TNF serum levels 24 h after SEB challenge, together with persistent expression of corresponding cytokine mRNA in spleen. The prolonged production of inflammatory cytokines in mice receiving L-NAME and SEB was associated with a 95% mortality rate within 96 h, whereas all mice survived injections of SEB or L-NAME alone. Both TNF and INF-gamma were responsible for the lethality induced by SEB in L-NAME-treated mice as shown by the protection provided by simultaneous administration of anti-IFN-gamma and anti-TNF mAbs. We conclude the SEB induces NO synthesis in vivo and that endogenous NO has protective effects in this model of T cell-dependent shock by downregulating IFN-gamma and TNF production.

The Potential Role of Staphylococcal Enterotoxin B in Rats with Postburn Staphylococcus aureus Sepsis

Shock ◽  
2003 ◽  
Vol 20 (3) ◽  
pp. 257-263 ◽  
Author(s):  
Hong-Yun Li ◽  
Yong-Ming Yao ◽  
Zhi-Guo Shi ◽  
Ning Dong ◽  
Yan Yu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Potential Role ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B
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