scholarly journals Role of Endogenous Interleukin-12 in Immune Response to Staphylococcal Enterotoxin B in Mice

2001 ◽  
Vol 69 (9) ◽  
pp. 5949-5952 ◽  
Author(s):  
Fanny N. Lauw ◽  
Sandrine Florquin ◽  
Peter Speelman ◽  
Sander J. H. van Deventer ◽  
Tom van der Poll
Keyword(s):  
Immune Response ◽  
Gamma Interferon ◽  
Staphylococcal Enterotoxin ◽  
Interleukin 12 ◽  
Staphylococcal Enterotoxin B ◽  
Induced Responses ◽  
Independent Mechanism ◽  
Enterotoxin B

ABSTRACT In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.

scholarly journals Memory T cells are anergic to the superantigen staphylococcal enterotoxin B.

1992 ◽  
Vol 176 (2) ◽  
pp. 575-579 ◽  
Author(s):  
W T Lee ◽  
E S Vitetta
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Staphylococcal Enterotoxin ◽  
Peripheral Tolerance ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

We have used staphylococcal enterotoxin B (SEB) to study the role of naive and memory T cells in the induction of peripheral tolerance. After administration of SEB to mice, the numbers of naive and memory T cells increase, as does the proportion of memory T cells, which are unresponsive to further stimulation with SEB in vitro. In addition, memory T cells generated in response to conventional antigen, which proliferate and provide help to B cells in the presence of the conventional antigen, fail to respond to superantigen. Hence, memory T cells, in general, are anergized by SEB. These results suggest that SEB-induced activation and anergy reflect the combined responses of naive and memory T cells. The differential activation vs. anergy of naive and memory T cells by superantigen may be related to cytokine production and may play an important role in the etiology of autoimmune diseases or immunodeficiency diseases such as acquired immune deficiency syndrome.

Possible Role of Staphylococcal Enterotoxin B in the Pathogenesis of Autoimmune Diseases

2015 ◽  
Vol 28 (7) ◽  
pp. 354-359 ◽  
Author(s):  
Jing Li ◽  
Jie Yang ◽  
Yu-wei Lu ◽  
Song Wu ◽  
Ming-rui Wang ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

scholarly journals Staphylococcal Enterotoxin B In Vivo Modulates both Gamma Interferon Receptor Expression and Ligand-Induced Activation of Signal Transducer and Activator of Transcription 1 in T Cells

2006 ◽  
Vol 75 (1) ◽  
pp. 306-313 ◽  
Author(s):  
R. Plaza ◽  
J. L. Rodriguez-Sanchez ◽  
C. Juarez
Keyword(s):  
T Cells ◽  
Gamma Interferon ◽  
Staphylococcal Enterotoxin ◽  
Receptor Expression ◽  
Protective Mechanism ◽  
Staphylococcal Enterotoxin B ◽  
Selective Blockade ◽  
Stat1 Signaling ◽  
Ifn Γ ◽  
Enterotoxin B

ABSTRACT Superantigens (SAg) are bacterial exotoxins that provoke extreme responses in the immune system; for example, the acute hyperactivation of SAg-reactive T cells that leads to toxic shock syndrome is followed within days by strong immunosuppression. The gamma interferon (IFN-γ) response is deeply affected in both extremes. The implication of IFN-γ in the pathophysiology of lethal shock induced in mice after a secondary challenge with the SAg staphylococcal enterotoxin B (SEB) prompted us to study the regulation of IFN-γ secretion and the intracellular response. We demonstrate in this study that a rechallenge with SEB becomes lethal only when given inside a critical time window after SEB priming and is associated with an increase of IFN-γ serum release 72 h after priming. However, at this time, a selective blockade of IFN-γ/STAT1 signaling develops in spleen cells, correlating with a lack of expression of the IFN-γ receptor beta subunit and STAT1 in the T-cell population. Selective blockade of the STAT1 signaling pathway—while simultaneously maintaining STAT3 signaling and expression—may be a protective mechanism that shortens IFN-γ production during the Th1 effector response. This blockade may also have consequences on switching towards a suppressor phenotype with chronic exposure to the superantigen.

Role of Staphylococcal Enterotoxin B on the Differentiation of Regulatory T Cells in Nasal Polyposis

2014 ◽  
Vol 28 (1) ◽  
pp. e17-e24 ◽  
Author(s):  
Soo-Na Cho ◽  
Chang-Hwa Song ◽  
Jun Jin ◽  
Sung Ha Kim ◽  
Ki-Sang Rha ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Nasal Polyposis ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

scholarly journals Role of specific IgE on staphylococcal enterotoxin B in chronic rhinosinusitis severity

2020 ◽  
Author(s):  
Suk Won Chang ◽  
Jeong Jin Park ◽  
Chi Sang Hwang ◽  
Jae Sung Nam ◽  
Jong‐Gyun Ha ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Specific Ige ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

772 Staphylococcal Enterotoxin B Triggers a Bystander Immune Response to Food Antigens Leading to Visceral Hypersensitivity

2016 ◽  
Vol 150 (4) ◽  
pp. S159
Author(s):  
Javier Aguilera-Lizarraga ◽  
Morgane Florens ◽  
Dafne Balemans ◽  
Stavroula Theofanous ◽  
Eluisa Perna ◽  
...  
Keyword(s):  
Immune Response ◽  
Staphylococcal Enterotoxin ◽  
Visceral Hypersensitivity ◽  
Staphylococcal Enterotoxin B ◽  
Food Antigens ◽  
Enterotoxin B

Staphylococcal enterotoxin B- mediated T cell immune response induces apoptosis in bladder cancer cells

2001 ◽  
Vol 37 ◽  
pp. S10
Author(s):  
Patricia L. Willert ◽  
Frank G.E. Perabo ◽  
Andreas Wirger ◽  
Berthold Amann ◽  
Doris H. Schmidt ◽  
...  
Keyword(s):  
Immune Response ◽  
Bladder Cancer ◽  
T Cell ◽  
Cancer Cells ◽  
Staphylococcal Enterotoxin ◽  
Cell Immune Response ◽  
Staphylococcal Enterotoxin B ◽  
Bladder Cancer Cells ◽  
Enterotoxin B
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