Acute contact urticaria to persulfate salts diagnosed with positive skin prick tests

Objectives3-(Bromomethyl)−2-chloro-4-(methylsulfonyl)-benzoic acid (BCMBA) has not previously been identified as a respiratory sensitiser. We detected two cases who presented respiratory and urticaria symptoms related to BCMBA and had positive skin prick tests to the agent. Subsequently, we conducted outbreak investigations at the BCMBA-producing factory and performed clinical examinations to confirm occupational diseases.MethodsThe outbreak investigations included observations of work processes, assessment of exposure, a medical survey with a questionnaire and skin prick tests with 0.5% BCMBA water solution on 85 exposed workers and 9 unexposed workers. We used specific inhalation or nasal challenge and open skin application test to investigate BCMBA-related occupational asthma, rhinitis and contact urticaria.ResultsWe identified nine workers with respiratory and/or skin symptoms and positive skin prick tests to BCMBA in a chemical factory. A survey among chemical factory workers indicated a BCMBA-related sensitisation rate of 8% among all exposed workers; the rate was highest (25%) among production workers in the production hall. Sensitisation was detected only in workers with the estimated highest exposure levels. Six cases of occupational asthma, rhinitis and/or contact urticaria caused by BCMBA were confirmed with challenge tests. Asthma-provoking doses in specific inhalation challenges were very low (0.03% or 0.3% BCMBA in lactose).ConclusionsWe identified a new low molecular weight agent causing occupational asthma, rhinitis and contact urticaria. A typical clinical picture of allergic diseases and positive skin prick tests suggest underlying IgE-mediated disease mechanisms. Stringent exposure control measures are needed in order to prevent BCMBA-related diseases.

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Eluted Substances From Hemodialysis Membranes Elicit Positive Skin Prick Tests in Bioincompatible Patients

Artificial Organs ◽

10.1111/aor.12392 ◽

2014 ◽

Vol 39 (4) ◽

pp. 343-351 ◽

Cited By ~ 8

Author(s):

Shuji Konishi ◽

Atsushi Fukunaga ◽

Hayato Yamashita ◽

Masahiro Miyata ◽

Makoto Usami

Keyword(s):

Positive Skin ◽

Skin Prick Tests

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Maternal Avoidance of Eggs, Cow's Milk, and Fish During Lactation: Effect on Allergic Manifestations, Skin-Prick Tests, and Specific IgE Antibodies in Children at Age 4 Years

PEDIATRICS ◽

10.1542/peds.89.4.735 ◽

1992 ◽

Vol 89 (4) ◽

pp. 735-739

Author(s):

Nele Sigurs ◽

Gunnar Hattevig ◽

Bengt Kjellman

Keyword(s):

Specific Ige ◽

Normal Diet ◽

Cow’S Milk ◽

Positive Skin ◽

Ige Antibodies ◽

Cow's Milk ◽

Number Of Children ◽

Specific Ige Antibodies ◽

Skin Prick Tests ◽

Allergic Manifestations

Two matched groups of children with a family history of atopy/allergy were observed from birth. In one group (n = 65) the mothers had a diet free from eggs, cow's milk, and fish during the first 3 months of lactation, whereas the mothers in the other group (n = 50) had a normal diet. Atopic/allergic manifestations, skin-prick tests, and specific IgE antibodies to egg white and cow's milk during the first 18 months of life have been reported previously. At 4 years of age the children underwent a clinical examination, skin-prick tests, and determination of specific IgE antibodies in serum against certain food and inhalant allergens. Both the cumulative incidence and the current prevalence of atopic dermatitis were significantly lower in the group of children whose mothers had adhered to a hypoallergenic diet during lactation, whereas all other atopic manifestations were similar. The number of children with positive skin-prick tests and specific IgE antibodies did not differ significantly, but the number of positive skin-prick tests and specific IgE antibody reactions in serum was significantly lower in the children of mothers adhering to the diet, indicating a milder degree of sensitization in these children.

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Lingual Tonsil Hypertrophy in Patients With Allergic Rhinitis

American Journal of Rhinology and Allergy ◽

10.1177/1945892419875086 ◽

2019 ◽

Vol 34 (1) ◽

pp. 87-92 ◽

Cited By ~ 1

Author(s):

Kübra Çoban ◽

Alper Köycü ◽

Erdinc Aydın

Keyword(s):

Allergic Rhinitis ◽

Healthy Volunteers ◽

Laryngopharyngeal Reflux ◽

Control Group ◽

Study Group ◽

Positive Skin ◽

Lingual Tonsil ◽

Immunglobulin E ◽

Skin Prick Tests ◽

Grade 3

Background Lingual tonsils, part of the Waldeyers’ Ring, are located in base of the tongue. They are commonly observed in childhood, due to increased immunological activity. Several factors such as laryngopharyngeal reflux, younger age, smoking, and obesity are associated with hypertrophy of lingual tonsils (LTH) in adulthood. However, the relation between allergic rhinitis and LTH is not clearly highlightened in the literature so far. Objective To investigate the role of allergic rhinitis in the development of LTH. Methods Adult patients who were diagnosed with allergic rhinitis were included in the study group. The control group consisted of age- and sex-match healthy volunteers. Complete otorhinolaryngology examination including fiberoptic endoscopic evaluation was performed to both groups. Blood samples were obtained for total immunglobulin E levels, and skin prick tests were performed to both groups. Patients with allergy complaints and positive skin prick tests were included in the study group, while healthy volunteers with negative skin prick tests were enrolled in the control group. The grading for LTH was achieved by a physician who was blind to the study. Results The incidence of LTH was significantly higher in the study group when compared to the control group ( P = .001). Similarly, the incidence of grade 3 LTH was significantly higher in the study group compared to the controls ( P = .002). Conclusion According to our results, LTH is more frequently observed in patients with allergic rhinitis. Grade 3 representing larger LTH is more commonly seen in patients with allergic rhinitis.

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