Prevalence of positive skin prick tests, allergic asthma, and rhinoconjunctivitis in teenagers in northern Sweden

Allergy ◽  
1994 ◽  
Vol 49 (10) ◽  
pp. 808-815 ◽  
Author(s):  
E. Norrman ◽  
L. Rosenhall ◽  
L. Nyström ◽  
E. Jönsson ◽  
N. Stjernberg
Author(s):  
Kate W. Sjoerdsma ◽  
W. James Metzger

Eosinophils are important to the pathogenesis of allergic asthma, and are increased in bronchoalveolar lavage within four hours after bronchoprovocation of allergic asthmatic patients, and remain significantly increased up to 24 hours later. While the components of human eosinophil granules have been recently isolated and purified, the mechanisms of degranulation have yet to be elucidated.We obtained blood from two volunteers who had a history of allergic rhinitis and asthma and a positive skin test (5x5mm wheal) to Alternaria and Ragweed. Eosinophils were obtained using a modification of the method described by Roberts and Gallin.


2014 ◽  
Vol 39 (4) ◽  
pp. 343-351 ◽  
Author(s):  
Shuji Konishi ◽  
Atsushi Fukunaga ◽  
Hayato Yamashita ◽  
Masahiro Miyata ◽  
Makoto Usami

PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 735-739
Author(s):  
Nele Sigurs ◽  
Gunnar Hattevig ◽  
Bengt Kjellman

Two matched groups of children with a family history of atopy/allergy were observed from birth. In one group (n = 65) the mothers had a diet free from eggs, cow's milk, and fish during the first 3 months of lactation, whereas the mothers in the other group (n = 50) had a normal diet. Atopic/allergic manifestations, skin-prick tests, and specific IgE antibodies to egg white and cow's milk during the first 18 months of life have been reported previously. At 4 years of age the children underwent a clinical examination, skin-prick tests, and determination of specific IgE antibodies in serum against certain food and inhalant allergens. Both the cumulative incidence and the current prevalence of atopic dermatitis were significantly lower in the group of children whose mothers had adhered to a hypoallergenic diet during lactation, whereas all other atopic manifestations were similar. The number of children with positive skin-prick tests and specific IgE antibodies did not differ significantly, but the number of positive skin-prick tests and specific IgE antibody reactions in serum was significantly lower in the children of mothers adhering to the diet, indicating a milder degree of sensitization in these children.


2019 ◽  
Vol 34 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Kübra Çoban ◽  
Alper Köycü ◽  
Erdinc Aydın

Background Lingual tonsils, part of the Waldeyers’ Ring, are located in base of the tongue. They are commonly observed in childhood, due to increased immunological activity. Several factors such as laryngopharyngeal reflux, younger age, smoking, and obesity are associated with hypertrophy of lingual tonsils (LTH) in adulthood. However, the relation between allergic rhinitis and LTH is not clearly highlightened in the literature so far. Objective To investigate the role of allergic rhinitis in the development of LTH. Methods Adult patients who were diagnosed with allergic rhinitis were included in the study group. The control group consisted of age- and sex-match healthy volunteers. Complete otorhinolaryngology examination including fiberoptic endoscopic evaluation was performed to both groups. Blood samples were obtained for total immunglobulin E levels, and skin prick tests were performed to both groups. Patients with allergy complaints and positive skin prick tests were included in the study group, while healthy volunteers with negative skin prick tests were enrolled in the control group. The grading for LTH was achieved by a physician who was blind to the study. Results The incidence of LTH was significantly higher in the study group when compared to the control group ( P = .001). Similarly, the incidence of grade 3 LTH was significantly higher in the study group compared to the controls ( P = .002). Conclusion According to our results, LTH is more frequently observed in patients with allergic rhinitis. Grade 3 representing larger LTH is more commonly seen in patients with allergic rhinitis.


1984 ◽  
Vol 56 (5) ◽  
pp. 1272-1277 ◽  
Author(s):  
C. A. Hirshman ◽  
H. Downes ◽  
L. Veith

We examined airway responsiveness to aerosols of Ascaris suum, citric acid, and methacholine chloride in the offspring of two highly allergic breeds of dogs: Basenji-greyhounds (BG) and Basenjis (B). The BG parents had airway hyperresponsiveness to citric acid and methacholine, whereas the B parents did not. Both BG and B offspring were allergic as measured by many positive skin tests. BG offspring, like their parents, were hyperresponsive to citric acid and methacholine, whereas B offspring were not. We conclude that familial rather than environmental factors are important for the development of nonspecific airway hyperresponsiveness as well as allergy in the BG dog model of asthma. Allergic asthma in these animals represents a combination of two discrete processes: allergy and nonspecific airway hyperresponsiveness.


2010 ◽  
Vol 9 (2) ◽  
pp. 91-96
Author(s):  
Roberto Ronchetti ◽  
Milos Jesenak ◽  
Francesco Ronchetti ◽  
Zuzana Rennerova

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Chris RuiWen Kuo ◽  
Rory Chan ◽  
Brian Lipworth

AbstractThe concept of the unified allergic airway disease (UAD) recognises the association between allergic inflammation in the upper and lower airways. Patients with asthma and concomitant allergic rhinitis experience more asthma-related primary and secondary care visits. We therefore aimed to determine differences in asthma control (asthma control questionnaire ACQ-6), lung function (spirometry) and T2 biomarkers (FeNO and Eos) in relation to the presence of allergic rhinitis in patients with allergic asthma. Retrospectively, we evaluated a cohort of 60 consecutive patients with persistent asthma attending our research unit for screening into clinical trials. All included subjects were receiving inhaled corticosteroids (ICS) and had a positive skin prick test (SPT) to at least one common aeroallergen to fulfil the criterion of allergic asthma. Patients with UAD had a diagnosis of allergic asthma in addition to established concomitant allergic rhinitis. T2 biomarkers were significantly higher in patients with allergic rhinitis in contrast to those without. FEV1 % predicted and FEF25-75 % predicted were also significantly lower in patients with concomitant allergic rhinitis. However, there was no difference in ACQ-6 observed between groups. In summary, patients with allergic asthma, the presence of concomitant allergic rhinitis is associated with worse lung function and higher type 2 biomarkers.


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