3-(Bromomethyl)-2-chloro-4-(methylsulfonyl)- benzoic acid: a new cause of sensitiser induced occupational asthma, rhinitis and urticaria

2017 ◽  
Vol 75 (4) ◽  
pp. 277-282 ◽  
Author(s):  
Hille Suojalehto ◽  
Kirsi Karvala ◽  
Saana Ahonen ◽  
Katriina Ylinen ◽  
Liisa Airaksinen ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Occupational Asthma ◽  
Water Solution ◽  
Control Measures ◽  
Positive Skin ◽  
Contact Urticaria ◽  
Exposed Workers ◽  
Chemical Factory ◽  
Outbreak Investigations ◽  
Skin Prick Tests

Objectives3-(Bromomethyl)−2-chloro-4-(methylsulfonyl)-benzoic acid (BCMBA) has not previously been identified as a respiratory sensitiser. We detected two cases who presented respiratory and urticaria symptoms related to BCMBA and had positive skin prick tests to the agent. Subsequently, we conducted outbreak investigations at the BCMBA-producing factory and performed clinical examinations to confirm occupational diseases.MethodsThe outbreak investigations included observations of work processes, assessment of exposure, a medical survey with a questionnaire and skin prick tests with 0.5% BCMBA water solution on 85 exposed workers and 9 unexposed workers. We used specific inhalation or nasal challenge and open skin application test to investigate BCMBA-related occupational asthma, rhinitis and contact urticaria.ResultsWe identified nine workers with respiratory and/or skin symptoms and positive skin prick tests to BCMBA in a chemical factory. A survey among chemical factory workers indicated a BCMBA-related sensitisation rate of 8% among all exposed workers; the rate was highest (25%) among production workers in the production hall. Sensitisation was detected only in workers with the estimated highest exposure levels. Six cases of occupational asthma, rhinitis and/or contact urticaria caused by BCMBA were confirmed with challenge tests. Asthma-provoking doses in specific inhalation challenges were very low (0.03% or 0.3% BCMBA in lactose).ConclusionsWe identified a new low molecular weight agent causing occupational asthma, rhinitis and contact urticaria. A typical clinical picture of allergic diseases and positive skin prick tests suggest underlying IgE-mediated disease mechanisms. Stringent exposure control measures are needed in order to prevent BCMBA-related diseases.

Acute contact urticaria to persulfate salts diagnosed with positive skin prick tests

2021 ◽  
Author(s):  
Alejandro R. Gratacós Gómez ◽  
Oscar M. González Jimenez ◽  
Juana B. Joyanes Romo ◽  
Alberto Palacios Cañas ◽  
Rosa Garcia Rodriguez ◽  
...  
Keyword(s):  
Positive Skin ◽  
Contact Urticaria ◽  
Skin Prick Tests

scholarly journals Collaboration: the key to investigations of emerging and re-emerging diseases

2021 ◽  
Vol 2 (1) ◽  
pp. 30-36
Author(s):  
Douglas L. Hatch ◽  
Imam Z. Imam
Keyword(s):  
Scientific Work ◽  
Emerging Diseases ◽  
Control Measures ◽  
Quality Of Data ◽  
International Agencies ◽  
Effective Interventions ◽  
Extensive Field ◽  
Outbreak Investigations ◽  
And Control ◽  
The Impact

Countries need teams of well trained epidemiologists with extensive field experience to work with clinicians and laboratory scientists to conduct prompt and effective outbreak investigations of epidemics. To identify these outbreaks of possible emerging or re-emerging problems, existing surveillance must be strengthened and the quality of data validated routinely. In addition, ministry of health officials and international agencies need an open, collaborative, scientific work environment. The best environment to design effective interventions and control measures to limit the impact of these newly identified problems on the public’s health is one of cooperation and collaboration

Eluted Substances From Hemodialysis Membranes Elicit Positive Skin Prick Tests in Bioincompatible Patients

2014 ◽  
Vol 39 (4) ◽  
pp. 343-351 ◽  
Author(s):  
Shuji Konishi ◽  
Atsushi Fukunaga ◽  
Hayato Yamashita ◽  
Masahiro Miyata ◽  
Makoto Usami
Keyword(s):  
Positive Skin ◽  
Skin Prick Tests

Maternal Avoidance of Eggs, Cow's Milk, and Fish During Lactation: Effect on Allergic Manifestations, Skin-Prick Tests, and Specific IgE Antibodies in Children at Age 4 Years

PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 735-739
Author(s):  
Nele Sigurs ◽  
Gunnar Hattevig ◽  
Bengt Kjellman
Keyword(s):  
Specific Ige ◽  
Normal Diet ◽  
Cow’S Milk ◽  
Positive Skin ◽  
Ige Antibodies ◽  
Cow's Milk ◽  
Number Of Children ◽  
Specific Ige Antibodies ◽  
Skin Prick Tests ◽  
Allergic Manifestations

Two matched groups of children with a family history of atopy/allergy were observed from birth. In one group (n = 65) the mothers had a diet free from eggs, cow's milk, and fish during the first 3 months of lactation, whereas the mothers in the other group (n = 50) had a normal diet. Atopic/allergic manifestations, skin-prick tests, and specific IgE antibodies to egg white and cow's milk during the first 18 months of life have been reported previously. At 4 years of age the children underwent a clinical examination, skin-prick tests, and determination of specific IgE antibodies in serum against certain food and inhalant allergens. Both the cumulative incidence and the current prevalence of atopic dermatitis were significantly lower in the group of children whose mothers had adhered to a hypoallergenic diet during lactation, whereas all other atopic manifestations were similar. The number of children with positive skin-prick tests and specific IgE antibodies did not differ significantly, but the number of positive skin-prick tests and specific IgE antibody reactions in serum was significantly lower in the children of mothers adhering to the diet, indicating a milder degree of sensitization in these children.

Lingual Tonsil Hypertrophy in Patients With Allergic Rhinitis

2019 ◽  
Vol 34 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Kübra Çoban ◽  
Alper Köycü ◽  
Erdinc Aydın
Keyword(s):  
Allergic Rhinitis ◽  
Healthy Volunteers ◽  
Laryngopharyngeal Reflux ◽  
Control Group ◽  
Study Group ◽  
Positive Skin ◽  
Lingual Tonsil ◽  
Immunglobulin E ◽  
Skin Prick Tests ◽  
Grade 3

Background Lingual tonsils, part of the Waldeyers’ Ring, are located in base of the tongue. They are commonly observed in childhood, due to increased immunological activity. Several factors such as laryngopharyngeal reflux, younger age, smoking, and obesity are associated with hypertrophy of lingual tonsils (LTH) in adulthood. However, the relation between allergic rhinitis and LTH is not clearly highlightened in the literature so far. Objective To investigate the role of allergic rhinitis in the development of LTH. Methods Adult patients who were diagnosed with allergic rhinitis were included in the study group. The control group consisted of age- and sex-match healthy volunteers. Complete otorhinolaryngology examination including fiberoptic endoscopic evaluation was performed to both groups. Blood samples were obtained for total immunglobulin E levels, and skin prick tests were performed to both groups. Patients with allergy complaints and positive skin prick tests were included in the study group, while healthy volunteers with negative skin prick tests were enrolled in the control group. The grading for LTH was achieved by a physician who was blind to the study. Results The incidence of LTH was significantly higher in the study group when compared to the control group ( P = .001). Similarly, the incidence of grade 3 LTH was significantly higher in the study group compared to the controls ( P = .002). Conclusion According to our results, LTH is more frequently observed in patients with allergic rhinitis. Grade 3 representing larger LTH is more commonly seen in patients with allergic rhinitis.

Utility of Whole Genome Sequencing To Describe the Persistence and Evolution of Listeria monocytogenes Strains within Crabmeat Processing Environments Linked to Two Outbreaks of Listeriosis

2018 ◽  
Vol 82 (1) ◽  
pp. 30-38 ◽  
Author(s):  
RICHARD ELSON ◽  
ADEDOYIN AWOFISAYO-OKUYELU ◽  
TREVOR GREENER ◽  
CRAIG SWIFT ◽  
ANAÏS PAINSET ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Surveillance Data ◽  
Control Measures ◽  
Whole Genome ◽  
Typing Method ◽  
Outbreak Investigations ◽  
Molecular Typing Method ◽  
Clinical Cases

ABSTRACT This article describes the identification and investigation of two extended outbreaks of listeriosis in which crabmeat was identified as the vehicle of infection. Comparing contemporary and retrospective typing data of Listeria monocytogenes isolates from clinical cases and from food and food processing environments allowed the detection of cases going back several years. This information, combined with the analysis of routinely collected enhanced surveillance data, helped to direct the investigation and identify the vehicle of infection. Retrospective whole genome sequencing (WGS) analysis of isolates provided robust microbiological evidence of links between cases, foods, and the environments in which they were produced and demonstrated that for some cases and foods, identified by fluorescent amplified fragment length polymorphism, the molecular typing method in routine use at the time, were not part of the outbreak. WGS analysis also showed that the strains causing illness had persisted in two food production environments for many years and in one producer had evolved into two strains over a period of around 8 years. This article demonstrates the value of reviewing L. monocytogenes typing data from clinical cases together with that from foods as a means of identifying potential vehicles and sources of infection in outbreaks of listeriosis. It illustrates the importance of reviewing retrospective L. monocytogenes typing alongside enhanced surveillance data to characterize extended outbreaks and inform control measures. Also, this article highlights the advantages of WGS analysis for strain discrimination and clarification of evolutionary relationships that refine outbreak investigations and improve our understanding of L. monocytogenes in the food chain.

Multiple norovirus outbreaks linked to imported frozen raspberries

2011 ◽  
Vol 140 (2) ◽  
pp. 260-267 ◽  
Author(s):  
E. SARVIKIVI ◽  
M. ROIVAINEN ◽  
L. MAUNULA ◽  
T. NISKANEN ◽  
T. KORHONEN ◽  
...  
Keyword(s):  
Control Measures ◽  
Test Results ◽  
Analytical Studies ◽  
Large School ◽  
Microbiological Methods ◽  
The Future ◽  
Outbreak Investigations ◽  
Foodborne Outbreaks

SUMMARYIn 2009, the number of foodborne norovirus outbreaks in Finland seemed markedly high, and many outbreaks seemed to be linked to imported frozen raspberries. We reviewed the data regarding all notified foodborne outbreaks in 2009 in Finland in order to assess the magnitude of the problem and to summarize the information on raspberry–linked outbreaks. Between March and August, 13 norovirus outbreaks affecting about 900 people could be linked to imported frozen raspberries. Two raspberry samples corresponding to two batches of raspberries were positive for norovirus. These two batches proved to have been the likely source in six of the 13 outbreaks. Analytical studies had not been conducted for six outbreaks, and virological test results were inconclusive in two. However, combining epidemiological and microbiological methods often enabled finding the source, as exemplified in investigation of a large school outbreak. To ensure prompt control measures in similar situations in the future, both aspects of outbreak investigations should be strengthened.

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