Outcome comparison of liver transplantation for hepatitis A-related versus hepatitis B-related acute liver failure in adult recipients

2017 ◽  
Vol 32 (1) ◽  
pp. e13140 ◽  
Author(s):  
Dong-Hwan Jung ◽  
Shin Hwang ◽  
Young-Suk Lim ◽  
Ki-Hun Kim ◽  
Chul-Soo Ahn ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis A ◽  
Outcome Comparison

scholarly journals Auxiliary partial orthotopic liver transplantation in acute liver failure due to hepatitis B

2002 ◽  
Vol 15 (7) ◽  
pp. 369-373 ◽  
Author(s):  
Sanjiv Saigal ◽  
Parthi Srinivasan ◽  
John Devlin ◽  
Bastiaan Boer ◽  
Buxton Thomas ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Orthotopic Liver Transplantation

scholarly journals Liver transplantation in acute liver failure due to Hepatitis B. Two clinical cases

2019 ◽  
pp. 100107
Author(s):  
Rocío Sedano ◽  
Lorena Castro ◽  
Mauricio Venegas ◽  
Julio Miranda ◽  
Carmen Hurtado ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Clinical Cases

scholarly journals Acute Liver Failure Requiring Liver Transplantation due to Acute Hepatitis A Virus Infection

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Chencheng Xie ◽  
Jonathan M. Fenkel ◽  
Dina L. Halegoua-DeMarzio ◽  
Jesse M. Civan ◽  
Danielle M. Tholey ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
University Hospital ◽  
Close Monitoring ◽  
King’S College Criteria ◽  
One Year

Introduction. Hepatitis A infection (HAV) is generally characterized by an acute icteric illness or may have a subclinical self-limited course, although rarely, can result in fulminant hepatitis and death. In 2019, the City of Philadelphia declared a public health emergency due to an HAV outbreak. We are reporting a series of four cases of acute liver failure (ALF) requiring liver transplantation (LT) due to acute HAV. Methods. Chart review and case descriptions of four patients with acute HAV-related ALF who were expeditiously evaluated, listed as Status 1A, and who underwent LT between August 2019 and October 2019 at Thomas Jefferson University Hospital. Results. All four patients presented with acute hepatocellular jaundice and had a positive HAV IgM, and all other causes of ALF were excluded. All four cases met the American Association for the Study of Liver Diseases (AASLD) criteria for ALF. Three of the four cases met King’s College Criteria of poor prognosis for nonacetaminophen-induced ALF. All four patients underwent successful LT and were discharged six to twelve days postoperatively. One patient died of disseminated Aspergillus infection five months after LT, while the others have had excellent clinical outcomes shown by one-year follow-ups. All four explants had remarkably similar histological changes, revealing acute hepatitis with massive necrosis accompanied by a prominent lymphoplasmacytic inflammatory infiltrate and bile ductular proliferation. Conclusion. Although rare, patients presenting with acute HAV need close monitoring as they may rapidly progress to ALF. Early referral to a transplant center afforded timely access to LT and yielded overall good one-year survival. Widespread HAV vaccination for high-risk individuals is an essential strategy for preventing disease and curbing such future outbreaks.

scholarly journals Systematic review of the global epidemiology of viral-induced acute liver failure

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e037473
Author(s):  
Jenna Patterson ◽  
Hannah Sophia Hussey ◽  
Sheetal Silal ◽  
Liz Goddard ◽  
Mashiko Setshedi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hepatitis B ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
Parvovirus B19 ◽  
Hepatitis E ◽  
Virus Hepatitis ◽  
Global Epidemiology

ObjectivesThe aetiology and burden of viral-induced acute liver failure remains unclear globally. It is important to understand the epidemiology of viral-induced ALF to plan for clinical case management and case prevention.ParticipantsThis systematic review was conducted to synthesize data on the relative contribution of different viruses to the aetiology of viral-induced acute liver failure in an attempt to compile evidence that is currently missing in the field. EBSCOhost, PubMed, ScienceDirect, Scopus and Web of Science were searched for relevant literature published from 2009 to 2019. The initial search was run on 9 April 2019 and updated via PubMed on 30 September 2019 with no new eligible studies to include. Twenty-five eligible studies were included in the results of this review.ResultsThis systematic review estimated the burden of acute liver failure after infection with hepatitis B virus, hepatitis A virus, hepatitis C virus, hepatitis E virus, herpes simplex virus/human herpesvirus, cytomegalovirus, Epstein-Barr virus and parvovirus B19. Data were largely missing for acute liver failure after infection with varicella-zostervirus, human parainfluenza viruses, yellow fever virus, coxsackievirus and/or adenovirus. The prevalence of hepatitis A-induced acute liver failur was markedly lower in countries with routine hepatitis A immunisation versus no routine hepatitis A immunisation. Hepatitis E virus was the most common aetiological cause of viral-induced acute liver failure reported in this review. In addition, viral-induced acute liver failure had poor outcomes as indicated by high fatality rates, which appear to increase with poor economic status of the studied countries.ConclusionsImmunisation against hepatitis A and hepatitis B should be prioritised in low-income and middle-income countries to prevent high viral-induced acute liver failure mortality rates, especially in settings where resources for managing acute liver failure are lacking. The expanded use of hepatitis E immunisation should be explored as hepatitis E virus was the most common cause of acute liver failure.RegistrationPROSPERO registration number: CRD42017079730.

Clinical recurrence of hepatitis A following liver transplantation for acute liver failure

1995 ◽  
Vol 45 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Edward Gane ◽  
Richard Sallie ◽  
Mohammed Saleh ◽  
Bernard Portmann ◽  
Roger Williams
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis A ◽  
Clinical Recurrence

scholarly journals Liver Transplantation Reverses Hepatic Myelopathy in 2 Children With Hepatitis A Infection

2021 ◽  
Vol 8 ◽  
pp. 2329048X2098376
Author(s):  
Roshan Koul ◽  
Bikrant Bihari Lal ◽  
Viniyendra Pamecha ◽  
Shiv Sarin ◽  
Seema Alam
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
End Of Life ◽  
End Of Life Care ◽  
Hepatitis A ◽  
Life Care ◽  
Failure Group ◽  
Donor Liver Transplantation ◽  
Neurological Features

Objectives: To report 2 children with acute hepatic myelopathy after hepatitis A infection who recovered completely after living donor liver transplantation. Methods: All the children admitted into liver intensive care unit (LICU) from November 1st 2018 to 31st October 2019, were evaluated for the neurological features. The data was collected from the admission register of the LICU unit in children below 15 years age. Medical records of these children were reviewed and data collected. Established clinical criteria were used to categorize the various grades of hepatic encephalopathy/myelopathy. Results: 37 children were seen over 1-year period between 6 months to 15 years age. There were 24 male(64.9%) and 13 females. Acute liver failure was seen in 19 (51.3%) and acute on chronic liver failure in 18 (48.7%). There were 10 cases of hepatitis A in acute liver failure group,10 of 19 cases (52.6%), while Wilson’s disease and undetermined etiology group formed the chronic group. 2 cases of hepatic myelopathy were seen in acute liver failure following hepatitis A infection. Both these children underwent live liver donor transplantation and recovered completely. Further in hepatitis A group,3 children had spontaneous recovery, 4 died and 1 child was discharged with end of life care. Overall out of all 37 children with liver failure,20 (54%) were discharged, 6 (16.2%) were advised end of life care and 11 (29.8%) died. Conclusion: Two cases (10.5%) of reversible hepatic myelopathy were seen in acute liver failure group of 19 cases. 18 out of 37 (48.6%) children had residual neurological features at discharge time.

Clinical features of patients with fulminant hepatitis A requiring emergency liver transplantation: comparison with acute liver failure due to other causes

2010 ◽  
Vol 16 (1) ◽  
pp. 19 ◽  
Author(s):  
Jin Dong Kim ◽  
Jong Young Choi ◽  
Chung-Hwa Park ◽  
Myeong Jun Song ◽  
Jeong Won Jang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Clinical Features ◽  
Fulminant Hepatitis ◽  
Hepatitis A

scholarly journals Acute HBV Related ALF- Successful Outcome with Oral Antiviral Treatment

2022 ◽  
Vol 5 (1) ◽  
pp. 01-03
Author(s):  
Parveen Malhotra ◽  
Vani Malhotra ◽  
Yogesh Sanwariya ◽  
Ajay Chugh ◽  
Isha Pahuja ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatic Encephalopathy ◽  
Hepatitis B ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Acute Hepatitis ◽  
Antiviral Treatment ◽  
Stable Condition ◽  
Successful Outcome ◽  
Acute Hepatitis B

Case report: We present a young female of fourteen years who was admitted to the hospital with short duration of Icterus, malaise, vomiting and diagnosed to be having acute hepatitis B. She went into acute liver failure as evidenced by development of hepatic encephalopathy and coagulopathy. She was managed on lines of hepatic encephalopathy along with oral antiviral treatment. She recovered successfully and was discharged after two weeks in heamodynamically stable condition. After a gap of six months, she became Hepatitis B surface (HbsAg) & hepatitis B e-antigen (HbeAg) negative and Hepatitis B Virus DNA (HBV DNA) was undetectable with normal liver function tests. She is on regular follow up for last one year and is absolutely normal. Conclusion: Acute hepatitis B can go into acute liver failure in 1% of cases, treatment for which includes liver transplantation and oral antiviral treatment which is especially helpful in cases who cannot afford liver transplantation, as was in our case.

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