Triple combination therapy of narrowband ultraviolet B, fractional carbon dioxide laser and topical bimatoprost 0.01% for non‐segmental vitiligo on non‐facial areas: A randomized half‐body, double‐blind, placebo‐controlled, comparative study

Objective. Keratosis pilaris (KP) is a common condition which can frequently be cosmetically disturbing. Topical treatments can be used with limited efficacy. The objective of this study is to evaluate the effectiveness and safety of fractional carbon dioxide (CO2) laser for the treatment of KP.Patients and Methods. A prospective, randomized, single-blinded, intraindividual comparative study was conducted on adult patients with KP. A single session of fractional CO2laser was performed to one side of arm whereas the contralateral side served as control. Patients were scheduled for follow-up at 4 and 12 weeks after treatment. Clinical improvement was graded subjectively by blinded dermatologists. Patients rated treatment satisfaction at the end of the study.Results. Twenty patients completed the study. All patients stated that the laser treatment improved KP lesions. At 12-week follow-up, 30% of lesions on the laser-treated side had moderate to good improvement according to physicians’ global assessment (p=0.02). Keratotic papules and hyperpigmentation appeared to respond better than the erythematous component. Four patients with Fitzpatrick skin type V developed transient pigmentary alteration.Conclusions. Fractional CO2laser treatment may be offered to patients with KP. Dark-skinned patients should be treated with special caution.

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Comparison between topical recombinant human epidermal growth factor and Aloe vera gel in combination with ablative fractional carbon dioxide laser as treatment for striae alba: A randomized double‐blind trial

Lasers in Surgery and Medicine ◽

10.1002/lsm.23052 ◽

2019 ◽

Vol 52 (2) ◽

pp. 166-175 ◽

Cited By ~ 3

Author(s):

Wareeporn Disphanurat ◽

Arisa Kaewkes ◽

Worapop Suthiwartnarueput

Keyword(s):

Carbon Dioxide ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Carbon Dioxide Laser ◽

Aloe Vera ◽

Double Blind Trial ◽

Double Blind ◽

Aloe Vera Gel ◽

Fractional Carbon Dioxide Laser ◽

Epidermal Growth

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A comparative study of fractional carbon dioxide laser, narrowband ultraviolet B and topical tacrolimus 0.1% ointment versus narrowband ultraviolet B, topical tacrolimus 0.1% ointment in stable vitiligo

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20200605 ◽

2020 ◽

Vol 6 (2) ◽

pp. 243

Author(s):

Anusha Putta ◽

Mohammed Waseem Javed

Keyword(s):

Comparative Study ◽

Carbon Dioxide Laser ◽

Laser System ◽

Treatment Protocol ◽

Drug Efficacy ◽

Ultraviolet B ◽

Topical Tacrolimus ◽

Recent Advancement ◽

Fractional Carbon Dioxide Laser ◽

Destruction Of Melanocytes

Background: Vitiligo, an acquired pigmentary disorder of skin and mucous membrane characterized by well circumscribed depigmented macules that occur secondary to selective destruction of melanocytes. Fractional CO2 laser system is a recent advancement in the treatment of vitiligo which works on the concept of fractional photo-thermolysis, in which microscopic treatment zones are created which help in increasing the penetration of topically applied agent which indirectly improves drug efficacy.Methods: A comparative study was conducted on 40 patients of stable vitiligo attending OPD, Dept of DVL with fractional CO2 laser, narrowband ultraviolet B (NBUVB) and topical tacrolimus 0.1% vs NBUVB, topical tacrolimus 0.1% for a duration of 4 months and patients were followed up for 12 weeks post treatment.Results: Patients on Fractional CO2 laser in combination with NBUVB and topical tacrolimus 0.1% ointment showed >50% improvement compared with other group, with duration for initiation of pigmentation being comparatively less.Conclusions: The treatment protocol with CO2 laser in combination with topical tacrolimus 0.1% cream and NBUVB for stable vitiligo was more effective than NBUVB and topical tacrolimus 0.1% alone and this study demonstrates that adding fractional CO2 laser improves repigmentation rate of vitiliginous lesions.

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