Decision letter for "Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice"

AbstractPersons suffering from opioid use disorder (OUD) experience long-lasting dysphoric symptoms well into extended periods of withdrawal. This protracted withdrawal syndrome is notably characterized by heightened anxiety. Here we investigate if an exacerbated withdrawal model of acute morphine dependence results in lasting behavioral adaptation 6 weeks into forced abstinence. We found that our exacerbated morphine withdrawal paradigm produced distinct impairments in elevated-plus maze, open field, and social interaction tests in male and female mice. These findings will be relevant for future investigation examining the neural mechanisms underlying these behaviors, and will aid in uncovering physiological sex differences in response to opioid withdrawal.

Download Full-text

Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice

European Journal of Neuroscience ◽

10.1111/ejn.14580 ◽

2020 ◽

Vol 51 (3) ◽

pp. 742-754 ◽

Cited By ~ 2

Author(s):

Isabel M. Bravo ◽

Brennon R. Luster ◽

Meghan E. Flanigan ◽

Patric J. Perez ◽

Elizabeth S. Cogan ◽

...

Keyword(s):

Behavioral Responses ◽

Opioid Withdrawal ◽

Male And Female

Download Full-text

Review for "Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice"

10.1111/ejn.14580/v1/review2 ◽

2019 ◽

Author(s):

Patrick Rothwell

Keyword(s):

Behavioral Responses ◽

Opioid Withdrawal ◽

Male And Female

Download Full-text

Invasion of Personal Space as a Function of Age, Sex, and Race

Psychological Reports ◽

10.2466/pr0.1976.38.3.959 ◽

1976 ◽

Vol 38 (3) ◽

pp. 959-965 ◽

Cited By ~ 7

Author(s):

Larry M. Dean ◽

Frank N. Willis ◽

James M. La Rocco

Keyword(s):

Motor Activity ◽

Exploratory Behavior ◽

Behavioral Response ◽

Behavioral Responses ◽

Personal Space ◽

Male And Female ◽

Black And White

Reactions to the invasion of personal space in terms of age, sex, and race of the invaders were investigated. Children, grouped by sex (male and female), race (black and white), and age (5, 8, and 10 yr. old), invaded the personal space of 192 adults grouped by sex (male and female) and race (black and white). The six types of behavioral responses were: avoidance, aggression, exploratory behavior, facilitative behavior, excess motor activity, and failure to respond. Responses to personal space invasion were not affected by sex. Blacks responded more often than whites but did not differ with regard to any particular type of behavioral response. Age of the invader had a significant effect on type of response given by adults whose personal space was invaded. It was concluded that the age of the invader was much more important than race or sex in determining the response to invasion of personal space.

Download Full-text