Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer’s Disease in wildtype mice

2021 ◽  
Author(s):  
Carey E Lyons ◽  
Xianxiao Zhou ◽  
Maria Razzoli ◽  
Mei Chen ◽  
Weiming Xia ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Psychosocial Stress ◽  
Chronic Psychosocial Stress

Chronic Stress Accelerates and Intensifies Aß-induced Alzheimer’s-disease-like Pathogenesis in Rat Models

US Neurology ◽  
2010 ◽  
Vol 06 (01) ◽  
pp. 32 ◽  
Author(s):  
Karim A Alkadhi ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Synaptic Plasticity ◽  
Chronic Stress ◽  
Psychosocial Stress ◽  
Signaling Molecules ◽  
Aβ Peptides ◽  
Rat Models ◽  
Chronic Psychosocial Stress

Apart from genetic factors, environmental factors such as stress may also play a critical role in the manifestation of Alzheimer’s disease (AD). We studied the impact of chronic psychosocial stress in two amyloid-beta (Aβ) rat models of AD by three approaches: learning and memory tests in the radial arm water maze, electrophysiological recordings of long-term potentiation (LTP) in anesthetized rats, and immunoblot analysis of synaptic plasticity- and cognition-related signaling molecules. The first Aβ rat model, representing established AD, was induced by continuous intracerebroventricular (ICV) infusion of a pathogenic dose of Aβ peptides via a 14-day osmotic pump. In this AD model, chronic stress intensified cognitive deficits, produced more depression of LTP, and accentuated the reduction of signaling molecule levels compared with the established model alone. The second model represents subjects that are clinically normal but are at risk for AD, and was induced by ICV infusion of a sub-threshold (sub-Aβ) dose of Aβ peptides. Chronic psychosocial stress was induced using a rat intruder model. Various tests showed that sub-Aβ rats were not significantly different from control rats. However, chronically stressed sub-Aβ rats showed more significant impairment of cognitive functions and early-phase LTP than that caused by stress alone. Molecular analysis revealed marked disturbances in the levels of essential signaling molecules in the stressed AD at-risk rats. These findings suggest that chronic stress may profoundly accelerate and intensify the impairment of cognition and synaptic plasticity in individuals at risk for AD and those with established AD, respectively. Possible mechanisms for the effect of chronic stress are discussed.

scholarly journals Chronic psychosocial stress enhances long-term depression in a subthreshold amyloid-beta rat model of Alzheimer’s disease

2011 ◽  
Vol 119 (2) ◽  
pp. 408-416 ◽  
Author(s):  
Trinh T. Tran ◽  
Marisa Srivareerat ◽  
Ibrahim A. Alhaider ◽  
Karim A. Alkadhi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Rat Model ◽  
Psychosocial Stress ◽  
Long Term Depression ◽  
Model Of Alzheimer’S Disease ◽  
Chronic Psychosocial Stress

scholarly journals Increased neuroanatomic risk for Alzheimer’s disease at preclinical stage: Exploring the interaction of fine particle exposure and psychosocial stress

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Diana Younan ◽  
Xinhui Wang ◽  
Andrew J Petkus ◽  
Tara L Gruenewald ◽  
Ramon Casanova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Psychosocial Stress ◽  
Fine Particle ◽  
Preclinical Stage ◽  
Particle Exposure

scholarly journals Diet, psychosocial stress, and Alzheimer's disease–related neuroanatomy in female nonhuman primates

2020 ◽  
Author(s):  
Brett M. Frye ◽  
Suzanne Craft ◽  
Thomas C. Register ◽  
Rachel N. Andrews ◽  
Susan E. Appt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Psychosocial Stress ◽  
Nonhuman Primates

scholarly journals P4-056: Work-life experience of psychosocial stress in relation to late-life risk of dementia and Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T684-T684
Author(s):  
Hui-Xin Wang ◽  
Maria Wahlberg ◽  
Anita Karp ◽  
Bengt Winblad ◽  
Laura Fratiglioni
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Psychosocial Stress ◽  
Life Experience ◽  
Late Life ◽  
Work Life

Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?

2017 ◽  
Vol 77 ◽  
pp. 148-164 ◽  
Author(s):  
Sami Piirainen ◽  
Andrew Youssef ◽  
Cai Song ◽  
Allan V. Kalueff ◽  
Gary E. Landreth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Psychosocial Stress ◽  
Cognitive Dysfunctions

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

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