Myelitis in inflammatory disorders associated with myelin oligodendrocyte glycoprotein antibody and aquaporin‐4 antibody: A comparative study in Chinese Han patients

2020 ◽  
Author(s):  
Jingzi ZhangBao ◽  
Wenjuan Huang ◽  
Lei Zhou ◽  
Liang Wang ◽  
Xuechun Chang ◽  
...  
Keyword(s):  
Comparative Study ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Aquaporin 4 ◽  
Chinese Han ◽  
Inflammatory Disorders ◽  
Aquaporin 4 Antibody

Comparison of the Response to Rituximab between Myelin Oligodendrocyte Glycoprotein and Aquaporin‐4 Antibody Diseases

2019 ◽  
Vol 87 (2) ◽  
pp. 256-266 ◽  
Author(s):  
Pierre Durozard ◽  
Audrey Rico ◽  
Clémence Boutiere ◽  
Adil Maarouf ◽  
Romaric Lacroix ◽  
...  
Keyword(s):  
Myelin Oligodendrocyte Glycoprotein ◽  
Aquaporin 4 ◽  
Aquaporin 4 Antibody

scholarly journals Comparison of Clinical Outcomes of Transverse Myelitis Among Adults With Myelin Oligodendrocyte Glycoprotein Antibody vs Aquaporin-4 Antibody Disease

2019 ◽  
Vol 2 (10) ◽  
pp. e1912732 ◽  
Author(s):  
Romina Mariano ◽  
Silvia Messina ◽  
Kurun Kumar ◽  
Wilhelm Kuker ◽  
Maria Isabel Leite ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Transverse Myelitis ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Aquaporin 4 ◽  
Aquaporin 4 Antibody

Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: Clinical and prognostic implications

2015 ◽  
Vol 22 (3) ◽  
pp. 312-319 ◽  
Author(s):  
Álvaro Cobo-Calvo ◽  
María Sepúlveda ◽  
Raphael Bernard-Valnet ◽  
Anne Ruiz ◽  
David Brassat ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Transverse Myelitis ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Aquaporin 4 ◽  
First Episode ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Increase Risk ◽  
Cerebrospinal Fluid Pleocytosis ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

Objective: We aimed to investigate the frequency and clinical significance of antibodies to myelin oligodendrocyte glycoprotein (MOG-abs) in patients who presented with a first episode of seronegative aquaporin 4 antibody (AQP4-ab) longitudinally extensive transverse myelitis (LETM). Methods: Epidemiological, clinical, and paraclinical data of 56 patients from three European centres were analysed. Patients were retrospectively tested for MOG-abs and AQP4-abs, by cell-based assays. Findings: Thirteen (23.2%) patients were MOG-ab positive. Among the 56 patients, six (10.7%) converted to neuromyelitis optica (NMO), one (1.8%) to multiple sclerosis (MS), nine (16.1%) had recurrent LETM, and 40 (71.4%) remained as monophasic LETM. Compared with seronegative patients, those with MOG-abs were younger (median: 32.5 vs 44 years; p=0.007), had cerebrospinal fluid pleocytosis more frequently (94% vs 45%, p=0.003) and had better outcome (median Expanded Disability Status Scale (EDSS) 2.0 vs 3.0, p=0.027). MOG-ab positive patients also showed an increase risk of optic neuritis relapse and NMO conversion ( p=0.010). Conclusion: Patients with MOG-abs in AQP4-ab seronegative LETM have clinical distinctive features, higher risk of optic neuritis relapses, and better outcome than patients seronegative.

Reader Response: Comparison of the Response to Rituximab between Myelin Oligodendrocyte Glycoprotein and Aquaporin‐4 Antibody Diseases

2020 ◽  
Vol 88 (2) ◽  
pp. 430-430
Author(s):  
Carolin Schwake ◽  
Kerstin Hellwig ◽  
Ralf Gold ◽  
Ilya Ayzenberg
Keyword(s):  
Reader Response ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Aquaporin 4 ◽  
Aquaporin 4 Antibody
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