Predictors of long-term quality of life after pediatric epilepsy surgery

Epilepsia ◽  
2015 ◽  
Vol 56 (6) ◽  
pp. 873-881 ◽  
Author(s):  
Klajdi Puka ◽  
Mary Lou Smith
Keyword(s):  
Quality Of Life ◽  
Epilepsy Surgery ◽  
Pediatric Epilepsy ◽  
Pediatric Epilepsy Surgery

scholarly journals Pediatric Epilepsy Surgery

2017 ◽  
Vol 32 (5) ◽  
pp. 467-474 ◽  
Author(s):  
Krista J. Qualmann ◽  
Christine G. Spaeth ◽  
Melanie F. Myers ◽  
Paul S. Horn ◽  
Katherine Holland ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
General Population ◽  
Epilepsy Surgery ◽  
Pediatric Epilepsy ◽  
Seizure Outcome ◽  
Cognitive Disability ◽  
Pediatric Epilepsy Surgery ◽  
Surgery Outcomes

Central nervous system comorbidities have been identified in patients with epilepsy. Several of these comorbidities have been correlated with poor surgery outcomes in patient cohorts. The authors sought to determine if prevalence of comorbidities in pediatric epilepsy surgery patients and their families correlate with long-term seizure outcome in a cross-sectional analysis. Three-generation pedigrees were elicited to compare family history of epilepsy, ADHD, anxiety, autism, bipolar disorder, cognitive disability, depression, migraine, and motor disability to surgery outcomes in 52 patients. Proportions of affected patients and relatives were compared to general population comorbidity rates and the patients’ most recent seizure outcome classification. Patients and families had significantly higher rates of comorbidities than the general population. Poorer long-term seizure outcomes following resective surgery were associated with autism or cognitive disability in patients. Together these data support evidence for a common pathophysiological mechanism between epilepsy and central nervous system comorbidities.

scholarly journals Acute postoperative seizures and long-term outcome following pediatric epilepsy surgery

Seizure ◽  
2014 ◽  
Vol 23 (6) ◽  
pp. 483-486 ◽  
Author(s):  
Hansel M. Greiner ◽  
Paul S. Horn ◽  
Ravindra Arya ◽  
Katherine Holland ◽  
Michele Turner ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
Pediatric Epilepsy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Pediatric Epilepsy Surgery

scholarly journals Predictors of quality of life after resective extratemporal epilepsy surgery in adults in long-term follow-up

Seizure ◽  
2009 ◽  
Vol 18 (7) ◽  
pp. 498-503 ◽  
Author(s):  
Alaa Eldin Elsharkawy ◽  
Theodor May ◽  
Rupprecht Thorbecke ◽  
Alois Ebner
Keyword(s):  
Quality Of Life ◽  
Epilepsy Surgery ◽  
Long Term Follow Up

Pediatric Epilepsy Surgery in Focal and Generalized Epilepsy: Current Trends and Recent Advancements

2021 ◽  
Author(s):  
William B. Harris ◽  
H. Westley Phillips ◽  
Aria Fallah ◽  
Gary W. Mathern
Keyword(s):  
Epilepsy Surgery ◽  
Intractable Epilepsy ◽  
Pediatric Epilepsy ◽  
Seizure Freedom ◽  
Surgical Interventions ◽  
Current Trends ◽  
Pediatric Epilepsy Surgery ◽  
Generalized Epilepsy ◽  
Epileptogenic Foci

AbstractFor a subset of children with medically intractable epilepsy, surgery may provide the best chances of seizure freedom. Whereas the indications for epilepsy surgery are commonly thought to be limited to patients with focal epileptogenic foci, modern imaging and surgical interventions frequently permit successful surgical treatment of generalized epilepsy. Resection continues to be the only potentially curative intervention; however, the advent of various neuromodulation interventions provides an effective palliative strategy for generalized or persistent seizures. Although the risks and benefits vary greatly by type and extent of intervention, the seizure outcomes appear to be uniformly favorable. Advances in both resective and nonresective surgical interventions provide promise for improved seizure freedom, function, and quality of life. This review summarizes the current trends and recent advancements in pediatric epilepsy surgery from diagnostic workup and indications through surgical interventions and postoperative outcomes.

scholarly journals Epilepsy Surgery for Pathologically Proven Hippocampal Sclerosis Provides Long‐term Seizure Control and Improved Quality of Life

Epilepsia ◽  
2004 ◽  
Vol 45 (3) ◽  
pp. 237-242 ◽  
Author(s):  
Adrian J. Lowe ◽  
Efraim David ◽  
Christine J. Kilpatrick ◽  
Zelko Matkovic ◽  
Mark J. Cook ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Epilepsy Surgery ◽  
Seizure Control ◽  
Hippocampal Sclerosis

LONG-TERM SEIZURES AND QUALITY OF LIFE AFTER EPILEPSY SURGERY COMPARED WITH MATCHED CONTROLS

Neurosurgery ◽  
2008 ◽  
Vol 62 (2) ◽  
pp. 326-335 ◽  
Author(s):  
Knut Stavem ◽  
Helge Bjørnæs ◽  
Iver A. Langmoen
Keyword(s):  
Quality Of Life ◽  
Epilepsy Surgery ◽  
Intractable Epilepsy ◽  
Two Dimensions ◽  
Three Dimensions ◽  
Seizure Type ◽  
Seizure Outcome

Abstract OBJECTIVE We compared long-term seizure outcome and health-related quality of life (HRQoL) of patients who underwent epilepsy surgery and matched medically treated nonsurgical controls with intractable epilepsy. METHODS Medically treated controls were identified for patients operated on for epilepsy between January 1, 1949 and December 31, 1992. We used a matched cohort design, matching for age, sex, and seizure type. The analysis was based on 70 complete matching pairs. HRQoL was assessed with the Quality of Life in Epilepsy Inventory 89 questionnaire an average of 15 years after surgery. RESULTS Among surgery patients, 48% were seizure-free during the previous year compared with 19% of the controls (P = 0.0004). Fewer surgery patients used antiepileptic drugs (70%) than controls (93%). The odds of being seizure-free were higher for surgery patients in total and in subgroups divided according to length of follow-up. The mean HRQoL for surgery patients was higher in five of the 17 Quality of Life in Epilepsy Inventory 89 dimensions and worse in none. Among patients with more than 7 years of follow-up, HRQoL was better in three dimensions and worse in none. Among patients with 7 years of follow-up or less, HRQoL was better in two dimensions and worse in the language dimension of the Quality of Life in Epilepsy Inventory 89. CONCLUSION After an average of more than 15 years of follow-up, epilepsy surgery patients had fewer seizures, used less antiepileptic medication, and had better HRQoL in several dimensions of the Quality of Life in Epilepsy Inventory 89 instrument than matched medically treated controls with refractory epilepsy, although possibly at a slight disadvantage in the language dimension among those with 7 years of follow-up or less.

Pediatric Epilepsy Surgery

Neurosurgery ◽  
2012 ◽  
Vol 71 (5) ◽  
pp. 985-993 ◽  
Author(s):  
Jason S. Hauptman ◽  
Kayvon Pedram ◽  
Christia Angela Sison ◽  
Raman Sankar ◽  
Noriko Salamon ◽  
...  
Keyword(s):  
Free Group ◽  
Epilepsy Surgery ◽  
Hippocampal Sclerosis ◽  
Outcome Data ◽  
Pediatric Epilepsy ◽  
Seizure Outcome ◽  
Seizure Recurrence ◽  
Single Institution ◽  
Pediatric Epilepsy Surgery

Abstract BACKGROUND: It is unclear whether long-term seizure outcomes in children are similar to those in adult epilepsy surgery patients. OBJECTIVE: To determine 5-year outcomes and antiepilepsy drug (AED) use in pediatric epilepsy surgery patients from a single institution. METHODS: The cohort consisted of children younger than 18 years of age whose 5-year outcome data would have been available by 2010. Comparisons were made between patients with and without 5-year data (n = 338), patients with 5-year data for seizure outcome (n = 257), and seizure-free patients on and off AEDs (n = 137). RESULTS: Five-year data were available from 76% of patients. More seizure-free patients with focal resections for hippocampal sclerosis and tumors lacked 5-year data compared with other cases. Of those with 5-year data, 53% were continuously seizure free, 18% had late seizure recurrence, 3% became seizure free after initial failure, and 25% were never seizure free. Patients were more likely to be continuously seizure free if their surgery was performed during the period 2001 to 2005 (68%) compared with surgery performed from 1996 to 2000 (61%), 1991 to 1995 (36%), and 1986 to 1990 (46%). More patients had 1 or fewer seizures per month in the late seizure recurrence (47%) compared with the not seizure-free group (20%). Four late deaths occurred in the not seizure-free group compared with 1 in the seizure-free group. Of patients who were continuously seizure free, 55% were not taking AEDs, and more cortical dysplasia patients (74%) had stopped taking AEDs compared with hemimegalencephaly patients (18%). CONCLUSION: In children, 5-year outcomes improved over 20 years of clinical experience. Our results are similar to those of adult epilepsy surgery patients despite mostly extratemporal and hemispheric operations for diverse developmental etiologies.

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