scholarly journals Toward evidence-based severity assessment in rat models with repeated seizures: I. Electrical kindling

Epilepsia ◽  
2018 ◽  
Vol 59 (4) ◽  
pp. 765-777 ◽  
Author(s):  
Christina Möller ◽  
Fabio Wolf ◽  
R. Maarten van Dijk ◽  
Valentina Di Liberto ◽  
Vera Russmann ◽  
...  
Keyword(s):  
Evidence Based ◽  
Severity Assessment ◽  
Rat Models ◽  
Electrical Kindling

scholarly journals Toward evidence‐based severity assessment in rat models with repeated seizures: II. Chemical post–status epilepticus model

Epilepsia ◽  
2019 ◽  
Vol 60 (10) ◽  
pp. 2114-2127 ◽  
Author(s):  
Ines Koska ◽  
Roelof Maarten van Dijk ◽  
Isabel Seiffert ◽  
Valentina Di Liberto ◽  
Christina Möller ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Evidence Based ◽  
Severity Assessment ◽  
Rat Models

scholarly journals Toward evidence‐based severity assessment in rat models with repeated seizures: III. Electrical post‐status epilepticus model

Epilepsia ◽  
2019 ◽  
Vol 60 (8) ◽  
pp. 1539-1551 ◽  
Author(s):  
Isabel Seiffert ◽  
Roelof Maarten van Dijk ◽  
Ines Koska ◽  
Valentina Di Liberto ◽  
Christina Möller ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Evidence Based ◽  
Severity Assessment ◽  
Rat Models

Where are we heading? Challenges in evidence-based severity assessment

2019 ◽  
Vol 54 (1) ◽  
pp. 50-62 ◽  
Author(s):  
Lydia M Keubler ◽  
Nils Hoppe ◽  
Heidrun Potschka ◽  
Steven R Talbot ◽  
Brigitte Vollmar ◽  
...  
Keyword(s):  
Study Design ◽  
Animal Experiments ◽  
Laboratory Animals ◽  
Ethical Responsibility ◽  
Evidence Based ◽  
Severity Assessment ◽  
Valid Data ◽  
Holistic Concept ◽  
Pain Distress

Evidence-based severity assessment in laboratory animals is, apart from the ethical responsibility, imperative to generate reproducible, standardized and valid data. However, the path towards a valid study design determining the degree of pain, distress and suffering experienced by the animal is lined with pitfalls and obstacles as we will elucidate in this review. Furthermore, we will ponder on the genesis of a holistic concept relying on multifactorial composite scales. These have to combine robust and reliable parameters to measure the multidimensional aspects that define the severity of animal experiments, generating a basis for the substantiation of the refinement principle.

Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL/6J mice

2018 ◽  
Vol 336 ◽  
pp. 261-268 ◽  
Author(s):  
Carina Bodden ◽  
Sophie Siestrup ◽  
Rupert Palme ◽  
Sylvia Kaiser ◽  
Norbert Sachser ◽  
...  
Keyword(s):  
Open Field ◽  
Field Testing ◽  
Evidence Based ◽  
Severity Assessment

Adapting an Evidence-Based Pediatric Acute Asthma Exacerbation Severity Assessment Tool for Pediatric Primary Care

2018 ◽  
Vol 32 (1) ◽  
pp. 10-20 ◽  
Author(s):  
Anne T. Magpuri ◽  
Jane K. Dixon ◽  
Ruth McCorkle ◽  
Angela A. Crowley
Keyword(s):  
Primary Care ◽  
Asthma Exacerbation ◽  
Assessment Tool ◽  
Acute Asthma ◽  
Pediatric Primary Care ◽  
Evidence Based ◽  
Severity Assessment ◽  
Acute Asthma Exacerbation

scholarly journals An Evidence-Based Review: The Effects of Malaysian Traditional Herbs on Osteoporotic Rat Models

2018 ◽  
Vol 25 (4) ◽  
pp. 6-30
Author(s):  
Nur Adlina Mohammad ◽  
◽  
Norfarah Izzaty Razaly ◽  
Mohd Dzulkhairi Mohd Rani ◽  
Muhammad Shamsir Mohd Aris ◽  
...  
Keyword(s):  
Evidence Based ◽  
Rat Models

Abstraction: An alternative neurocognitive account of recognition, prediction, and decision making

2020 ◽  
Vol 43 ◽  
Author(s):  
Valerie F. Reyna ◽  
David A. Broniatowski
Keyword(s):  
Decision Making ◽  
Software Engineering ◽  
Systems Engineering ◽  
Evidence Based ◽  
Extensive Literature ◽  
Trace Theory ◽  
Fuzzy Trace Theory ◽  
Abstract Representations ◽  
Technical Systems

Abstract Gilead et al. offer a thoughtful and much-needed treatment of abstraction. However, it fails to build on an extensive literature on abstraction, representational diversity, neurocognition, and psychopathology that provides important constraints and alternative evidence-based conceptions. We draw on conceptions in software engineering, socio-technical systems engineering, and a neurocognitive theory with abstract representations of gist at its core, fuzzy-trace theory.

Misophonia: An Evidence-Based Case Report

2020 ◽  
Vol 29 (4) ◽  
pp. 685-690
Author(s):  
C. S. Vanaja ◽  
Miriam Soni Abigail
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Case History ◽  
Pure Tone ◽  
Physiological Responses ◽  
Evidence Based ◽  
Management Option ◽  
Pure Tone Audiogram

Purpose Misophonia is a sound tolerance disorder condition in certain sounds that trigger intense emotional or physiological responses. While some persons may experience misophonia, a few patients suffer from misophonia. However, there is a dearth of literature on audiological assessment and management of persons with misophonia. The purpose of this report is to discuss the assessment of misophonia and highlight the management option that helped a patient with misophonia. Method A case study of a 26-year-old woman with the complaint of decreased tolerance to specific sounds affecting quality of life is reported. Audiological assessment differentiated misophonia from hyperacusis. Management included retraining counseling as well as desensitization and habituation therapy based on the principles described by P. J. Jastreboff and Jastreboff (2014). A misophonia questionnaire was administered at regular intervals to monitor the effectiveness of therapy. Results A detailed case history and audiological evaluations including pure-tone audiogram and Johnson Hyperacusis Index revealed the presence of misophonia. The patient benefitted from intervention, and the scores of the misophonia questionnaire indicated a decrease in the severity of the problem. Conclusions It is important to differentially diagnose misophonia and hyperacusis in persons with sound tolerance disorders. Retraining counseling as well as desensitization and habituation therapy can help patients who suffer from misophonia.

Meeting the Best Practice for Hearing Aid Verification in Children: Challenges and Future Directions

2019 ◽  
Vol 28 (4) ◽  
pp. 877-894
Author(s):  
Nur Azyani Amri ◽  
Tian Kar Quar ◽  
Foong Yen Chong
Keyword(s):  
Clinical Practice ◽  
Hearing Aids ◽  
Best Practice ◽  
Hearing Aid ◽  
Evidence Based ◽  
Future Directions ◽  
Major Barrier ◽  
Klang Valley ◽  
Age Range ◽  
Fitting Hearing Aids

Purpose This study examined the current pediatric amplification practice with an emphasis on hearing aid verification using probe microphone measurement (PMM), among audiologists in Klang Valley, Malaysia. Frequency of practice, access to PMM system, practiced protocols, barriers, and perception toward the benefits of PMM were identified through a survey. Method A questionnaire was distributed to and filled in by the audiologists who provided pediatric amplification service in Klang Valley, Malaysia. One hundred eight ( N = 108) audiologists, composed of 90.3% women and 9.7% men (age range: 23–48 years), participated in the survey. Results PMM was not a clinical routine practiced by a majority of the audiologists, despite its recognition as the best clinical practice that should be incorporated into protocols for fitting hearing aids in children. Variations in practice existed warranting further steps to improve the current practice for children with hearing impairment. The lack of access to PMM equipment was 1 major barrier for the audiologists to practice real-ear verification. Practitioners' characteristics such as time constraints, low confidence, and knowledge levels were also identified as barriers that impede the uptake of the evidence-based practice. Conclusions The implementation of PMM in clinical practice remains a challenge to the audiology profession. A knowledge-transfer approach that takes into consideration the barriers and involves effective collaboration or engagement between the knowledge providers and potential stakeholders is required to promote the clinical application of evidence-based best practice.

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