scholarly journals A computer model of the equine arterial circulation to gain deeper insights into equine arterial haemodynamics

2019 ◽  
Vol 51 (S53) ◽  
pp. 20-20
Gut ◽  
1998 ◽  
Vol 43 (6) ◽  
pp. 843-848 ◽  
Author(s):  
T Iwao ◽  
K Oho ◽  
R Nakano ◽  
M Yamawaki ◽  
T Sakai ◽  
...  

Aims—To investigate the relation between changes in splanchnic arterial haemodynamics and renal arterial haemodynamics in controls and patients with cirrhosis.Methods—Superior mesenteric artery pulsatility index (SMA-PI) and renal artery pulsatility index (R-PI) were measured using Doppler ultrasonography in 24 controls and 36 patients with cirrhosis. These measurements were repeated 30 minutes after ingestion of a liquid meal or placebo. Sixteen controls and 24 patients received the meal, and eight controls and 12 patients received placebo.Results—In the fasting condition, patients with cirrhosis had a lower SMA-PI (p<0.01) and a greater R-PI (p<0.01) compared with controls. Placebo ingestion had no effect on splanchnic and renal haemodynamics. In contrast, ingestion of the meal caused a notable reduction in SMA-PI (p<0.01, p<0.01) and an increase in R-PI (p<0.01, p<0.01) in controls and patients with cirrhosis. The meal induced haemodynamic change in SMA-PI was inversely correlated with that in R-PI in controls (t=−0.42, p<0.05) and in patients with cirrhosis (t=−0.29, p<0.05).Conclusions—Results support the hypothesis that renal arterial vasoconstriction seen in patients with cirrhosis is one of the kidney’s homoeostatic responses to underfilling of the splanchnic arterial circulation.


PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0221425 ◽  
Author(s):  
Lisse Vera ◽  
Daimé Campos Arias ◽  
Sofie Muylle ◽  
Nikos Stergiopulos ◽  
Patrick Segers ◽  
...  

2004 ◽  
Vol 171 (4S) ◽  
pp. 420-420
Author(s):  
Sijo J. Parekattil ◽  
Paul Shin ◽  
Anthony J. Thomas ◽  
Ashok Agarwal
Keyword(s):  

VASA ◽  
2001 ◽  
Vol 30 (Supplement 58) ◽  
pp. 21-27
Author(s):  
Luther

In diabetic foot disease, critical limb ischaemia (CLI) cannot be precisely described using established definitions. For clinical use, the Fontaine classification complemented with any objective verification of a reduced arterial circulation is sufficient for decision making. For scientific purposes, objective measurement criteria should be reported. Assessment of CLI should rely on the physical examination of the limb arteries, complemented by laboratory tests like the shape of the PVR curve at ankle or toe levels, and arteriography. The prognosis of CLI in diabetic foot disease depends on the success of arterial reconstruction. The best prognosis for the patients is with a preserved limb. Reconstructive surgery is the best choice for the majority of patients.


1997 ◽  
Vol 36 (04/05) ◽  
pp. 237-240
Author(s):  
P. Hammer ◽  
D. Litvack ◽  
J. P. Saul

Abstract:A computer model of cardiovascular control has been developed based on the response characteristics of cardiovascular control components derived from experiments in animals and humans. Results from the model were compared to those obtained experimentally in humans, and the similarities and differences were used to identify both the strengths and inadequacies of the concepts used to form the model. Findings were confirmatory of some concepts but contrary to some which are firmly held in the literature, indicating that understanding the complexity of cardiovascular control probably requires a combination of experiments and computer models which integrate multiple systems and allow for determination of sufficiency and necessity.


2019 ◽  
Vol 27 (2) ◽  
pp. 74-77
Author(s):  
Victoria Team ◽  
Georgina Gethin ◽  
John D Ivory ◽  
Kimberley Crawford ◽  
Ayoub Bouguettaya ◽  
...  

Venous leg ulcers (VLUs) are a significant complication amongst persons with chronic venous insufficiency (CVI) that frequently follow a cycle of healing and recurrence. Current clinical practice guidelines (CPGs) recommend applying below knee compression to improve VLU healing. Compression could be applied if the Ankle Brachial Pressure Index (ABPI) rules out significant arterial disease, as sufficient peripheral arterial circulation is necessary to ensure safe compression use. We conducted a content analysis of 13 global CPGs on the accuracy of recommendations related to ABPI and compression application. Eight CPGs indicated that compression is recommended when the ABPI is between 0.8 and 1.2 mmHg. However, this review found there is disagreement between 13 global VLU CPGs, with a lack of clarity on whether or not compression is indicated for patients with ABPIs between 0.6 and 0.8 mmHg. Some CPGs recommend reduced compression for treatment of VLUs, while others do not recommend any type of compression at all. This has implications for when it is safe to apply compression, and the inconsistency in evidence indicates that specialist advice may be required at levels beyond the ABPI “safe” range listed above.


1991 ◽  
Vol 19 (3) ◽  
pp. 122-141 ◽  
Author(s):  
C. Wright ◽  
G. L. Pritchett ◽  
R. J. Kuster ◽  
J. D. Avouris

Abstract A method for determining the effect of suspension dynamics on tire wear has been developed. Typical city cycle maneuvers are defined by instrumented vehicle testing and data in the form of forward velocities and steer angles are used as an input to an ADAMS computer model of the vehicle. A simulation of the maneuvers generates a tire's operating environment in the form of normal load, slip, and camber variations, which contain all the subtle effects of the vehicle's suspension, steering, and handling characteristics. A cyclic repetition of the tire's operating environment is constructed and used to control an MTS Flat-Trac machine. In this way, accelerated tire wear can be generated in the laboratory which is directly related to the design features of the vehicle's suspension and steering systems.


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