Short Chain Fatty Acids Increase Intracellular Calcium Levels and Enhances Gut Hormone Release from STC‐1 cells via Transient Receptor Potential Ankyrin1

2021 ◽  
Author(s):  
Vibhu Kumar ◽  
Pragyanshu Khare ◽  
Kirti Devi ◽  
Jasleen Kaur ◽  
Vijay Kumar ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Intracellular Calcium ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Hormone Release ◽  
Gut Hormone ◽  
Transient Receptor ◽  
Chain Fatty Acids

scholarly journals Short chain fatty acids enhance expression and activity of the umami taste receptor in enteroendocrine cells via a Gαi/o pathway

2020 ◽  
Author(s):  
Matilda Shackley ◽  
Edward W. Tate ◽  
Alastair J.H. Brown ◽  
Gary Frost ◽  
Aylin C. Hanyaloglu
Keyword(s):  
Fatty Acids ◽  
Monosodium Glutamate ◽  
Taste Receptor ◽  
Short Chain Fatty Acids ◽  
Enteroendocrine Cells ◽  
Short Chain ◽  
Mrna Levels ◽  
Umami Taste ◽  
Gut Hormone ◽  
Chain Fatty Acids

AbstractThe short chain fatty acids (SCFAs) acetate, butyrate and propionate, are produced by the fermentation of non-digestible carbohydrates by the gut microbiota. SCFAs are of interest because they regulate appetite, adiposity, metabolism, glycemic control and immunity. SCFAs act at two distinct G protein-coupled receptors (GPCRs), FFAR2 and FFAR3. These are expressed in intestinal enteroendocrine cells (EECs), where they mediate SCFA-driven anorectic gut hormone release. EECs also express other GPCRs that act as nutrient sensors, in a manner that is plastic and adaptable to the environment. SCFAs may elicit some of their health-promoting effects by altering levels of GPCRs in EECs, thus, enhancing gut sensitivity to dietary molecules. Here, we identified that exposure of the murine EEC STC-1 cell-line to a concentration of SCFAs found in the colon, specifically enhances mRNA levels of the umami taste receptors TASR1 and TASR3, without altering levels of the SCFA GPCRs, FFAR2 and FFAR3. Interestingly, treatment of EECs with propionate or butyrate, but not acetate, increased levels of umami receptor transcripts. This phenomenon was reversed by inhibiting Gαi/o signaling with pertussis toxin, suggesting that SCFAs act through FFAR2/3 to alter gene expression. Surprisingly, neither a FFAR3-nor a FFAR2-selective synthetic ligand could increase TASR1/TASR3 mRNA levels. We assessed the functional impact of increases in TASR1/TASR3 expression using unique pharmacological properties of the umami taste receptor; namely, the potentiation of signaling by inosine monophosphate. We found that the umami taste receptor induced inosine-1-phosphate and calcium signaling in response to L-alanine and L-monosodium glutamate, and that butyrate pretreatment significantly enhanced such signaling. Our study reveals that SCFAs may contribute to EEC adaptation and alter EEC sensitivity to bioactive nutrients.

Effect of short-chain fatty acids on the ethylene pathway in embryonic axes of Cicer arietinum during germination

1994 ◽  
Vol 92 (4) ◽  
pp. 629-635 ◽  
Author(s):  
Mercedes Gallardo ◽  
Paloma Munoz De Rueda ◽  
Angel Jesus Matilla ◽  
Isabel Maria Sanchez-Calle
Keyword(s):  
Fatty Acids ◽  
Cicer Arietinum ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Embryonic Axes ◽  
Chain Fatty Acids

Short-Chain Fatty Acids Prevent Diabetic Nephropathy In Vivo and In Vitro

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 92-OR ◽  
Author(s):  
WEI HUANG ◽  
YONG XU ◽  
YOUHUA XU ◽  
LUPING ZHOU ◽  
CHENLIN GAO
Keyword(s):  
Fatty Acids ◽  
Diabetic Nephropathy ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

1898-P: Colonic Short-Chain Fatty Acids Lower Endogenous Glucose Production

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1898-P
Author(s):  
ADELINA I.L. LANE ◽  
SAVANNA N. WENINGER ◽  
FRANK DUCA
Keyword(s):  
Fatty Acids ◽  
Glucose Production ◽  
Short Chain Fatty Acids ◽  
Endogenous Glucose Production ◽  
Short Chain ◽  
Endogenous Glucose ◽  
Chain Fatty Acids

Concentrations and Correlations of Faecal Short-chain Fatty Acids and Faecal Water Content in Man

1994 ◽  
Vol 7 (6) ◽  
Author(s):  
U. Siigur ◽  
K. E. Norin ◽  
G. Allgood ◽  
T. Schlagheck ◽  
Tore Midtvedt
Keyword(s):  
Fatty Acids ◽  
Water Content ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

Short Chain Fatty Acids, Menaquinones and Ubiquinones and Their Effects on the Host

2000 ◽  
Vol 12 (2) ◽  
Author(s):  
Carla Pruzzo ◽  
Roberta Capretti ◽  
Paola Mastrantonio
Keyword(s):  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids
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