scholarly journals MetastamiRs: A promising choice for antihepatocellular carcinoma nucleic acid drug development

2016 ◽  
Vol 47 (1) ◽  
pp. 80-94 ◽  
Author(s):  
Liangcai Wu ◽  
Xue Bai ◽  
Yuan Xie ◽  
Zhen Yang ◽  
Xiaobo Yang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Drug Development ◽  
Nucleic Acid Drug

A Multi-Model Approach to Nucleic Acid-Based Drug Development

BioDrugs ◽  
2004 ◽  
Vol 18 (1) ◽  
pp. 37-50 ◽  
Author(s):  
Isabelle Gautherot ◽  
Reg??s Sodoyer
Keyword(s):  
Nucleic Acid ◽  
Drug Development ◽  
Model Approach

scholarly journals Cover Picture: Nanopore-Based Analysis of Chemically Modified DNA and Nucleic Acid Drug Targets (Isr. J. Chem. 6-7/2013)

2013 ◽  
Vol 53 (6-7) ◽  
pp. 317-317
Author(s):  
Joseph Larkin ◽  
Spencer Carson ◽  
Daniel H. Stoloff ◽  
Meni Wanunu
Keyword(s):  
Nucleic Acid ◽  
Drug Targets ◽  
Chemically Modified ◽  
Modified Dna ◽  
Nucleic Acid Drug

DAPI - pUC8 complex: A tool to investigate biological effects of nucleic acid-drug interaction

1987 ◽  
Vol 145 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Giorgio Palu' ◽  
Sebastiano Valisena ◽  
Maria Luisa Barcellona ◽  
Lanfranco Masotti ◽  
Giovanni A. Meloni
Keyword(s):  
Drug Interaction ◽  
Nucleic Acid ◽  
Biological Effects ◽  
Nucleic Acid Drug

scholarly journals Nucleic Acid Drugs for Prevention of Cardiac Rejection

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Jun-ichi Suzuki ◽  
Mitsuaki Isobe ◽  
Ryuichi Morishita ◽  
Ryozo Nagai
Keyword(s):  
Nucleic Acid ◽  
Chronic Rejection ◽  
Experimental Studies ◽  
Arterial Disease ◽  
Inflammatory Factors ◽  
Cis Element ◽  
Double Stranded Dna ◽  
Cardiac Rejection ◽  
Disease Related Genes ◽  
Nucleic Acid Drug

Heart transplantation has been broadly performed in humans. However, occurrence of acute and chronic rejection has not yet been resolved. Several inflammatory factors, such as cytokines and adhesion molecules, enhance the rejection. The graft arterial disease (GAD), which is a type of chronic rejection, is characterized by intimal thickening comprised of proliferative smooth muscle cells. Specific treatments that target the attenuation of acute rejection and GAD formation have not been well studied in cardiac transplantation. Recent progress in the nucleic acid drugs, such as antisense oligodeoxynucleotides (ODNs) to regulate the transcription of disease-related genes, has important roles in therapeutic applications. Transfection of cis-element double-stranded DNA, named as “decoy,” has been also reported to be a useful nucleic acid drug. This decoy strategy has been not only a useful method for the experimental studies of gene regulation but also a novel clinical strategy. In this paper, we reviewed the experimental results ofNF-κB, E2F, AP-1, and STAT-1 decoy and other ODNs using the experimental heart transplant models.

Progress in Nanoparticulate Systems for Peptide, Proteins and Nucleic Acid Drug Delivery

2011 ◽  
Vol 12 (11) ◽  
pp. 1823-1839 ◽  
Author(s):  
Stanislaw Slomkowski ◽  
Mateusz Gosecki
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Nanoparticulate Systems ◽  
Nucleic Acid Drug

scholarly journals Statistical Genetics Contributes to the Nucleic Acid Drug Discovery

2020 ◽  
Vol 109 (1) ◽  
pp. 107-112
Author(s):  
Saori Sakaue ◽  
Yukinori Okada
Keyword(s):  
Drug Discovery ◽  
Nucleic Acid ◽  
Statistical Genetics ◽  
Nucleic Acid Drug
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