Prognostic significance of low skeletal muscle mass compared with protein-energy malnutrition in liver cirrhosis

2017 ◽  
Vol 47 (10) ◽  
pp. 1042-1052 ◽  
Author(s):  
Hiroki Nishikawa ◽  
Hirayuki Enomoto ◽  
Akio Ishii ◽  
Yoshinori Iwata ◽  
Yuho Miyamoto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Cirrhosis ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Protein Energy Malnutrition ◽  
Prognostic Significance ◽  
Protein Energy

A Novel Method for Measuring Skeletal Muscle Mass in Liver Cirrhosis Using Adobe Photoshop

2014 ◽  
Vol 109 ◽  
pp. S170
Author(s):  
Pavan Mankal ◽  
Priya Simoes ◽  
Ahmad Hakimzada ◽  
Imad Asaad ◽  
Adel Asaad ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Cirrhosis ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Adobe Photoshop ◽  
Novel Method

scholarly journals Loss of Skeletal Muscle Mass Affects the Incidence of Minimal Hepatic Encephalopathy: A Case Control Study

2020 ◽  
Author(s):  
Masakuni Tateyama ◽  
Hideaki Naoe ◽  
Motohiko Tanaka ◽  
Kentaro Tanaka ◽  
Satoshi Narahara ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Cirrhosis ◽  
Hepatic Encephalopathy ◽  
Mass Loss ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Lumbar Vertebra ◽  
Minimal Hepatic Encephalopathy ◽  
Skeletal Muscle Index ◽  
Muscle Mass Loss

Abstract Background: Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but little is known about whether sarcopenia and/or muscle mass loss are related to minimal hepatic encephalopathy.Methods: To clarify the relationship between minimal hepatic encephalopathy and sarcopenia and/or muscle mass loss in patients with liver cirrhosis. Ninety-nine patients with liver cirrhosis were enrolled. Minimal hepatic encephalopathy was diagnosed by a neuropsychiatric test. Skeletal mass index was calculated by dividing muscle area at the third lumbar vertebra by the square of height in meters.Results: MHE was detected in 48 cases (48.5%) and sarcopenia in 6 cases (6.1%). Patients were divided into two groups, with or without MHE. Comparing groups, no significant differences were seen in serum ammonia concentration or rate of sarcopenia. Skeletal muscle index was smaller in patients with minimal hepatic encephalopathy (46.4 cm2/m2) than in those without (51.2 cm2/m2, P = 0.027). Skeletal muscle index represented a predictive factor related to minimal hepatic encephalopathy (<50 cm2/m2; odds ratio 0.300, P = 0.002).Conclusions: Muscle mass loss was related to minimal hepatic encephalopathy, although sarcopenia was not. Measurement of muscle mass loss might be useful to predict MHE.

Skeletal Muscle Mass (SMM) Reduction With Decompensation of Liver Cirrhosis Differs by Sex

2014 ◽  
Vol 109 ◽  
pp. S164-S165
Author(s):  
Priya Simoes ◽  
Pavan Mankal ◽  
Ahmad Hakimzada ◽  
Imad Asaad ◽  
Adel Asaad ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Cirrhosis ◽  
Muscle Mass ◽  
Skeletal Muscle Mass

scholarly journals Sarcopenia and Frailty in Liver Cirrhosis

Life ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 399
Author(s):  
Hiroki Nishikawa ◽  
Shinya Fukunishi ◽  
Akira Asai ◽  
Shuhei Nishiguchi ◽  
Kazuhide Higuchi
Keyword(s):  
Skeletal Muscle ◽  
Liver Cirrhosis ◽  
Physical Function ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Current Knowledge ◽  
The Elderly ◽  
The Body ◽  
Assessment Criteria ◽  
Skeletal Muscle Atrophy

Skeletal muscle is the largest organ in the body, and skeletal muscle atrophy results from a shift in the balance of protein synthesis and degradation toward protein breakdown. Primary sarcopenia is defined as a loss of skeletal muscle mass and strength or physical function due to aging, and secondary sarcopenia is defined as a loss of skeletal muscle mass and strength or physical function due to underlying diseases. Liver cirrhosis (LC) is one of the representative diseases which can be complicated with secondary sarcopenia. Muscle mass loss becomes more pronounced with worsening liver reserve in LC patients. While frailty encompasses a state of increased vulnerability to environmental factors, there is also the reversibility of returning to a healthy state with appropriate intervention. Several assessment criteria for sarcopenia and frailty were proposed in recent years. In 2016, the Japan Society of Hepatology created assessment criteria for sarcopenia in liver disease. In Japan, health checkups for frailty in the elderly aged 75 years or more started in April 2020. Both sarcopenia and frailty can be adverse predictors for cirrhotic patients. In this review article, we will summarize the current knowledge of sarcopenia and frailty in LC patients.

scholarly journals Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis

2021 ◽  
Vol 60 (5) ◽  
pp. 745-750
Author(s):  
Ryotaro Sakamori ◽  
Ryoko Yamada ◽  
Kazuma Shinkai ◽  
Akira Doi ◽  
Yuki Tahata ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Decompensated Liver Cirrhosis

scholarly journals Combined Albumin-Bilirubin Grade and Skeletal Muscle Mass as a Predictor in Liver Cirrhosis

2019 ◽  
Vol 8 (6) ◽  
pp. 782 ◽  
Author(s):  
Hiroki Nishikawa ◽  
Hirayuki Enomoto ◽  
Kazunori Yoh ◽  
Yoshinori Iwata ◽  
Yoshiyuki Sakai ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Cirrhosis ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Assessment Methods ◽  
Time Dependent ◽  
Grading System ◽  
Prognostic Impact ◽  
Operating Characteristics ◽  
Roc Curve Analysis

We aimed to compare the prognostic impact among albumin-bilirubin (ALBI) grade, the Child-Pugh classification and our proposed combined ALBI grade and skeletal muscle mass (SMM) grading system in patients with liver cirrhosis (LC) (n = 468, 254 males and 214 females) using the Akaike information criterion (AIC) and time-dependent receiver operating characteristics (ROC) curve analysis. SMM was tested using bioimpedance analysis. Male subjects with skeletal muscle mass index (SMI) <7.0 cm2/m2 and female subjects with SMI <5.7 cm2/m2 were defined as having low SMM. Patients with ALBI grade 1, 2 and 3 were given 1, 2 and 3 points. Patients with and without low SMM were given 1 and 0 point, respectively. The sum of the point of ALBI (1, 2, or 3) and SMM (0 or 1) was defined as the ALBI-SMM grade. The value obtained with the AIC for survival by the ALBI-SMM grade was the lowest among three assessment methods (AIC: 513.418 in ALBI grade, 533.584 in Child-Pugh classification and 493.72 in ALBI-SMM grade). In time-dependent ROC analysis, all area under the ROCs of the ALBI-SMM grade in each time point were the highest among three assessment methods. In conclusion, the ALBI-SMM grading system can be helpful for LC patients.

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